Rifapentine

Generic Name: rifapentine (RIF-a-PEN-teen)
Brand Name: Priftin

Rifapentine is used for:

Treating tuberculosis (TB). It is used along with other medicines.

Rifapentine is a rifamycin antibiotic. It works by killing or stopping the growth of TB organisms.

Do NOT use rifapentine if:

  • you are allergic to any ingredient in rifapentine or to rifamycins (eg, rifampin)
  • you have the blood disease porphyria

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

Before using rifapentine:

Some medical conditions may interact with rifapentine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems, abnormal liver function tests, HIV, or severe diarrhea caused by antibiotic use (pseudomembranous colitis)

Some MEDICINES MAY INTERACT with rifapentine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for infections, HIV, TB, heart problems, irregular heartbeat, anxiety, mood or mental problems, depression, asthma, inflammation, allergic reactions, pain, high blood pressure, diabetes, birth control, blood thinning, high cholesterol, thyroid replacement, seizures, erectile dysfunction, and other conditions) may interact with rifapentine

This may not be a complete list of all interactions that may occur. Ask your health care provider if rifapentine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use rifapentine:

Use rifapentine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take rifapentine by mouth with food.
  • To clear up your infection completely, take rifapentine for the full course of treatment. Keep taking it even if you feel better in a few days.
  • It may take several months for rifapentine to work. Do not stop taking rifapentine without checking with your doctor.
  • If you miss a dose of rifapentine, contact your doctor right away.

Ask your health care provider any questions you may have about how to use rifapentine.

Important safety information:

  • Rifapentine may cause dizziness. This effects may be worse if you take it with alcohol or certain medicines. Use rifapentine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Rifapentine may color body tissues or fluids (eg, skin, teeth, tongue, urine, stools, sweat, saliva, tears) an orange or red color. Rifapentine may permanently stain contact lenses or dentures.
  • Rifapentine may color the urine, stools, sweat, saliva, or tears orange or red. Rifapentine may permanently stain contact lenses.
  • Rifapentine only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use rifapentine for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of rifapentine may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you take the antibiotic or within several months after you stop taking it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Tell your doctor or dentist that you take rifapentine before you receive any medical or dental care, emergency care, or surgery.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using rifapentine. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Rifapentine may cause low or high blood sugar levels. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. To prevent low blood sugar, eat meals at the same time each day and do not skip meals. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Rifapentine may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking rifapentine.
  • Lab tests, including liver function, complete blood cell counts, platelet counts, and bilirubin levels, may be performed while you use rifapentine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Rifapentine should be used with extreme caution in CHILDREN younger than 12 years; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking rifapentine while you are pregnant. It is not known if this drug is found in breast milk. Do not breast-feed while taking rifapentine.

Possible side effects of rifapentine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; constipation; decreased appetite; diarrhea; discoloration of body fluids (red or orange); dizziness; headache; increased sweating; nausea; stomach pain; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; bloody stools; fever; frequent or painful urination; irregular heartbeat; joint pain or swelling; severe or persistent diarrhea; stomach pain or cramps; symptoms of infection (eg, fever, chills, sore throat); symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, vomiting, or loss of appetite; general body discomfort); unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include headache; heartburn; increased urinary frequency; itching.

Proper storage of rifapentine:

Store rifapentine below 77 degrees F (25 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep rifapentine out of the reach of children and away from pets.

General information:

  • If you have any questions about rifapentine, please talk with your doctor, pharmacist, or other health care provider.
  • Rifapentine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take rifapentine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about rifapentine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to rifapentine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using rifapentine.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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