Generic Name: quinupristin/dalfopristin (KWIN-ue-PRIS-tin/DAL-foe-PRIS-tin)
Brand Name: Synercid
Quinupristin/dalfopristin is used for:
Treating infections caused by certain bacteria. It may also be used for other conditions as determined by your doctor.
Quinupristin/dalfopristin is a streptogramin antibiotic. It works by blocking the production of proteins needed by the bacteria to survive.
Do NOT use quinupristin/dalfopristin if:
- you are allergic to any ingredient in quinupristin/dalfopristin or to another streptogramin (eg, pristinamycin)
- you are taking amiodarone, astemizole, bepridil, a ketolide (eg, telithromycin), a macrolide (eg, clarithromycin, erythromycin), pimozide, quinidine, tacrolimus, terfenadine, or ziprasidone
Contact your doctor or health care provider right away if this applies to you.
Before using quinupristin/dalfopristin:
Some medical conditions may interact with quinupristin/dalfopristin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of liver or kidney problems, stomach or bowel problems (eg, colitis, severe diarrhea caused by antibiotic use), HIV infection, high blood bilirubin levels, or a heart condition
- if you are overweight
Some MEDICINES MAY INTERACT with quinupristin/dalfopristin. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Antiarrhythmics (eg, amiodarone, disopyramide, quinidine), astemizole, bepridil, calcium channel blockers (eg, diltiazem, nifedipine, verapamil), carbamazepine, cisapride, cyclosporine, diazepam, docetaxel, HIV protease inhibitors (eg, indinavir, ritonavir), HMG-CoA reductase inhibitors ("statins") (eg, lovastatin), ketolides (eg, telithromycin), macrolides (eg, clarithromycin, erythromycin), methylprednisolone, midazolam, nonnucleoside reverse transcriptase inhibitors (NNRTIs) (eg, delavirdine, nevirapine), paclitaxel, pimozide, tacrolimus, terfenadine, vinca alkaloids (eg, vinblastine), or ziprasidone because the risk of their side effects may be increased by quinupristin/dalfopristin
This may not be a complete list of all interactions that may occur. Ask your health care provider if quinupristin/dalfopristin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use quinupristin/dalfopristin:
Use quinupristin/dalfopristin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Quinupristin/dalfopristin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using quinupristin/dalfopristin at home, a health care provider will teach you how to use it. Be sure you understand how to use quinupristin/dalfopristin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use quinupristin/dalfopristin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- To clear up your infection completely, use quinupristin/dalfopristin for the full course of treatment. Keep using it even if you feel better in a few days.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of quinupristin/dalfopristin, contact your doctor right away.
Ask your health care provider any questions you may have about how to use quinupristin/dalfopristin.
Important safety information:
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
- Quinupristin/dalfopristin only works against bacteria; it does not treat viral infections (eg, the common cold).
- Be sure to use quinupristin/dalfopristin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Long-term or repeated use of quinupristin/dalfopristin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Quinupristin/dalfopristin should be used with extreme caution in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using quinupristin/dalfopristin while you are pregnant. It is not known if quinupristin/dalfopristin is found in breast milk. If you are or will be breast-feeding while you use quinupristin/dalfopristin, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of quinupristin/dalfopristin:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Joint pain; mild diarrhea; muscle pain; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or dark urine; bloody or watery stools; chest pain; confusion; dizziness; fainting; fast or irregular heartbeat; fatigue; fever, chills, or persistent sore throat; leg or calf pain, redness, swelling, or tenderness; one-sided weakness; pain, swelling, itching, or burning at the injection site; seizures; severe muscle or joint pain; severe or persistent diarrhea or vomiting; slurred speech; stomach or back pain or cramps; tremor; unusual tiredness or weakness; vision problems; white patches in the mouth; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include loss of coordination; tremors; trouble breathing; vomiting.Proper storage of quinupristin/dalfopristin:
Quinupristin/dalfopristin is usually handled and stored by a health care provider. If you are using quinupristin/dalfopristin at home, store quinupristin/dalfopristin as directed by your pharmacist or health care provider. Keep quinupristin/dalfopristin out of the reach of children and away from pets.
- If you have any questions about quinupristin/dalfopristin, please talk with your doctor, pharmacist, or other health care provider.
- Quinupristin/dalfopristin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take quinupristin/dalfopristin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about quinupristin/dalfopristin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to quinupristin/dalfopristin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using quinupristin/dalfopristin.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about dalfopristin/quinupristin
- Other brands: Synercid