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Quinidine gluconate controlled-release tablets

Pronunciation

Generic Name: quinidine gluconate (KWIN-ih-deen)
Brand Name: Generic only. No brands available.

Quinidine gluconate controlled-release tablets is associated with an increased risk of death when used to treat non-life-threatening irregular heartbeat. This risk may be greater if you have structural heart disease. Talk with your doctor for more information.


Quinidine gluconate controlled-release tablets is used for:

Treating and preventing abnormal heart rhythms.

Quinidine gluconate controlled-release tablets is an antiarrhythmic. It works by stabilizing the heart rhythm in conditions in which the heart is beating too fast or in an irregular rhythm (antiarrhythmic effect).

Do NOT use quinidine gluconate controlled-release tablets if:

  • you are allergic to any ingredient in quinidine gluconate controlled-release tablets
  • you have certain severe, uncontrolled abnormal heart rhythms or muscle weakness due to myasthenia gravis, or you have previously developed unusual bruising while using quinidine gluconate controlled-release tablets or similar medications
  • you are currently taking astemizole, codeine, cisapride, a class III antiarrhythmic (eg, amiodarone), grepafloxacin, an H1 antagonist (eg, diphenhydramine), itraconazole, a ketolide (eg, telithromycin), a macrolide (eg, erythromycin), a nondepolarizing muscle relaxant (eg, pancuronium), a phenothiazine (eg, chlorpromazine), a phosphodiesterase type 5 inhibitor (eg, sildenafil), pimozide, a quinolone (eg, ciprofloxacin), ritonavir, sparfloxacin, succinylcholine, terfenadine, voriconazole, or medicine for myasthenia gravis

Contact your doctor or health care provider right away if any of these apply to you.

Before using quinidine gluconate controlled-release tablets:

Some medical conditions may interact with quinidine gluconate controlled-release tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney disease; congestive heart failure, a history of heart block, QT prolongation, or other heart problems; low blood pressure; high or low blood calcium levels; decreased blood platelets; or digitalis intoxication

Some MEDICINES MAY INTERACT with quinidine gluconate controlled-release tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nifedipine, or rifampin because the effectiveness of quinidine gluconate controlled-release tablets may be decreased
  • Amiloride, amiodarone, carbonic anhydrase inhibitors (eg, acetazolamide), cimetidine, itraconazole, ketoconazole, thiazide diuretics (eg, hydrochlorothiazide), verapamil, or voriconazole because side effects, such as increased risk of low blood pressure or heart conduction disturbances and racing heart rate, dizziness, or fainting, may occur
  • Arsenic, cisapride, class III antiarrhythmics (eg, amiodarone), dofetilide, droperidol, H1 antagonists (eg, diphenhydramine), haloperidol, HIV protease inhibitors (eg, indinavir), ketolides (eg, telithromycin), macrolides (eg, erythromycin), phenothiazines (eg, chlorpromazine), phosphodiesterase type 5 inhibitors (eg, sildenafil), pimozide, quinolones, streptogramins (eg, pristinamycin), or ziprasidone because the actions and side effects of quinidine gluconate controlled-release tablets and these medicines may be increased
  • Anticoagulants (eg, warfarin), aripiprazole, beta-adrenergic blockers (eg, metoprolol), digitoxin, digoxin, nondepolarizing muscle relaxants (eg, pancuronium), norepinephrine reuptake inhibitors (eg, atomoxetine), procainamide, propafenone, or succinylcholine because the actions or side effects of these medicines may be increased
  • Anticholinesterases (eg, pyridostigmine) or narcotic analgesics (eg, codeine) because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if quinidine gluconate controlled-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use quinidine gluconate controlled-release tablets:

Use quinidine gluconate controlled-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Quinidine gluconate controlled-release tablets may be taken with or without food. Take quinidine gluconate controlled-release tablets with a full glass of water.
  • Swallow whole. Do not crush or chew before swallowing.
  • Do not lie down for 30 minutes after taking quinidine gluconate controlled-release tablets.
  • Do not drink grapefruit juice or eat grapefruit while taking quinidine gluconate controlled-release tablets.
  • Use quinidine gluconate controlled-release tablets on a regular schedule around the clock, unless otherwise directed by your doctor.
  • If you miss a dose of quinidine gluconate controlled-release tablets, take it as soon as possible. If it is almost time for our next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use quinidine gluconate controlled-release tablets.

Important safety information:

  • Quinidine gluconate controlled-release tablets may cause dizziness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to quinidine gluconate controlled-release tablets.
  • Quinidine gluconate controlled-release tablets may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to quinidine gluconate controlled-release tablets. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • Do not suddenly stop taking quinidine gluconate controlled-release tablets without checking with your doctor.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using quinidine gluconate controlled-release tablets.
  • LAB TESTS may be performed to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use quinidine gluconate controlled-release tablets with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using quinidine gluconate controlled-release tablets during pregnancy. Quinidine gluconate controlled-release tablets is excreted in breast milk. Do not breast-feed while you are taking quinidine gluconate controlled-release tablets.

Possible side effects of quinidine gluconate controlled-release tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; diarrhea; heartburn; nausea; stomach discomfort; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; deafness; dizziness; fainting; fast or slow heartbeat; headache; hearing loss; irregular heartbeat; lightheadedness; liver toxicity; pale stools; psychotic reactions; ringing in ears; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; disturbed vision; fainting; fast or slow heartbeat; low blood pressure; ringing in the ears; trouble breathing; trouble walking.

Proper storage of quinidine gluconate controlled-release tablets:

Store between 59 and 86 degrees F (15 and 30 degrees C). Keep quinidine gluconate controlled-release tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about quinidine gluconate controlled-release tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Quinidine gluconate controlled-release tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take quinidine gluconate controlled-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about quinidine gluconate controlled-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to quinidine gluconate controlled-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using quinidine gluconate controlled-release tablets.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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