Quibron-300

Generic Name: guaifenesin/theophylline (gwye-FEN-e-sin/thee-OFF-i-lin)
Brand Name: Quibron and Quibron-300

Quibron-300 is used for:

Preventing and treating symptoms and blockage of airway due to asthma or other lung diseases such as emphysema or bronchitis. It may also be used for other conditions as determined by your doctor.

Quibron-300 is a combination xanthine derivative and expectorant. The xanthine derivative works by relaxing the smooth muscle surrounding the bronchial tubes (air passages) of the lungs, allowing the tubes to widen, and making breathing easier. Quibron-300 improves contraction of the diaphragm (the major breathing muscle). The expectorant works by increasing respiratory secretions and loosening mucus in the airways.

Do NOT use Quibron-300 if:

  • you are allergic to any ingredient in Quibron-300 (including ethylenediamine), similar medicines (eg, aminophylline), or xanthines (eg, caffeine, chocolate)
  • you are using large amounts of other products that contain xanthine (such as chocolate or caffeinated drinks)
  • you have ulcers or a seizure disorder for which you are not taking medicine
  • you are taking dipyridamole intravenously (IV), halothane, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Quibron-300:

Some medical conditions may interact with Quibron-300. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems (eg, congestive heart failure, cor pulmonale), an irregular heartbeat, a history of ulcers, fluid in the lungs (pulmonary edema), liver problems, fever, viral infection, severe infection (eg, blood infection), thyroid problems, cystic fibrosis, increased acid levels in the body, brain or nerve problems, or seizures (eg, epilepsy)
  • if you are in shock
  • if you smoke, are stopping or starting smoking, or are exposed to the smoke from cigarettes or marijuana
  • if you are in the last 3 months of pregnancy

Some MEDICINES MAY INTERACT with Quibron-300. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aminoglutethimide, barbiturates (eg, phenobarbital), beta-blockers (eg, propranolol), carbamazepine, hydantoins (eg, phenytoin), isoproterenol, moricizine, propafenone, rifampin, St. John's wort, or sulfinpyrazone because they may decrease Quibron-300's effectiveness
  • Allopurinol, cimetidine, disulfiram, enoxacin, estrogen, fluvoxamine, interferon alpha-a, macrolide antibiotics (eg, clarithromycin, erythromycin), methotrexate, mexiletine, oral contraceptives (birth control pills), pentoxifylline, quinolone antibiotics (eg, ciprofloxacin), tacrine, thiabendazole, ticlopidine, troleandomycin, verapamil, viloxazine, or zileuton because they may increase the risk of Quibron-300's side effects
  • Ephedrine because the risk of side effects such as nausea, nervousness, and trouble sleeping may be increased
  • Halothane because the risk of the risk of side effects such as irregular heartbeat may be increased
  • Ketamine because the risk of seizures may be increased
  • Adenosine, benzodiazepines (eg, diazepam, lorazepam), dipyridamole IV, lithium, midazolam, or nondepolarizing muscle relaxants (eg, pancuronium) because their effectiveness may be decreased by Quibron-300

This may not be a complete list of all interactions that may occur. Ask your health care provider if Quibron-300 may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Quibron-300:

Use Quibron-300 as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Some foods may change the effectiveness or increase the side effects of Quibron-300. Talk to your doctor about how you should take Quibron-300 with regard to food. Do not suddenly change your diet or eating habits without first checking with your doctor.
  • Take Quibron-300 at evenly spaced times throughout the day. Taking Quibron-300 at the same time each day will help you remember to take it. Contact your doctor with any questions or concerns about the best way to take Quibron-300.
  • If you miss a dose of Quibron-300, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Quibron-300.

Important safety information:

  • Use of alcohol may increase the risk of side effects of Quibron-300. Talk to your doctor before drinking alcohol while you are taking Quibron-300.
  • Tell your doctor or dentist that you take Quibron-300 before you receive any medical or dental care, emergency care, or surgery.
  • Carry an ID card at all times that says you take Quibron-300.
  • Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).
  • Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; if you start or stop smoking cigarettes or marijuana; or if another doctor prescribes a new medication or tells you to stop using a medication that you have already been taking.
  • Quibron-300 will not stop an asthma attack once one has started. Be sure to always carry appropriate rescue medicine (eg, bronchodilator inhaler) with you in case of an asthma attack.
  • If you have more than one doctor, be sure to tell each of your doctors that you are taking Quibron-300.
  • Diabetes patients - Quibron-300 may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including blood theophylline levels, may be performed while you use Quibron-300. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Quibron-300 with caution in the ELDERLY; they may be more sensitive to its effects.
  • Caution is advised when using Quibron-300 in CHILDREN, especially newborns with kidney problems; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Quibron-300 while you are pregnant. Quibron-300 is found in breast milk. If you are or will be breast-feeding while you use Quibron-300, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Quibron-300:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild and temporary changes in behavior; temporary increased urination.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; diarrhea; dizziness; fast breathing; heart rhythm problems or irregular heartbeats; nausea; persistent headache; seizures; sleeplessness; tremors; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; chest pain; confusion; decreased urination; fast or irregular heartbeat; headache; increased thirst; irritability; loss of appetite; muscle pain or tenderness; nausea; nervousness; persistent increased urination; restlessness; seizures; severe or persistent diarrhea; stomach pain; tremors or twitching; vomiting, especially of blood.

Proper storage of Quibron-300:

Store Quibron-300 at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), in tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Do not refrigerate. Keep Quibron-300 out of the reach of children and away from pets.

General information:

  • If you have any questions about Quibron-300, please talk with your doctor, pharmacist, or other health care provider.
  • Quibron-300 is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Quibron-300. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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