Prochlorperazine syrup

Pronunciation

Generic Name: prochlorperazine (pro-klor-PURR-uh-zeen)
Brand Name: Compazine

Prochlorperazine syrup is used for:

Controlling severe nausea and vomiting and treating schizophrenia. It is also used for the short-term (4 weeks) treatment of generalized nonpsychotic anxiety. It may also be used for other conditions as determined by your doctor.

Prochlorperazine syrup is a phenothiazine. It works by blocking a certain chemical (dopamine) in the brain.

Do NOT use prochlorperazine syrup if:

  • you are allergic to any ingredient in prochlorperazine syrup or similar medicines
  • you are taking astemizole, cisapride, or terfenadine
  • you have severe central nervous system depression

Contact your doctor or health care provider right away if any of these apply to you.

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Before using prochlorperazine syrup:

Some medical conditions may interact with prochlorperazine syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart disease, central nervous system depression, blood problems, liver problems, low blood pressure, increased pressure in the eye, neuroleptic malignant syndrome, tardive dyskinesia, bone marrow problems, unusual muscle movements, Parkinson disease, a predisposition to glaucoma, Reye syndrome, prostate problems, or seizures, or you have alcoholism

Some MEDICINES MAY INTERACT with prochlorperazine syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine) or lithium because they may decrease prochlorperazine syrup's effectiveness
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine), general anesthetics (eg, thiopental), haloperidol, methyldopa, or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects, such as seizures, may be increased
  • ACE inhibitors (eg, enalapril), anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine), astemizole, cisapride, dofetilide, haloperidol, hydantoins (eg, phenytoin), methyldopa, metrizamide, naltrexone, polypeptide antibiotics (eg, actinomycin), serotonin receptor antagonist antiemetics (eg, ondansetron), terfenadine, tramadol, trazodone, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by prochlorperazine syrup
  • Bromocriptine, guanethidine, levodopa, or pergolide because their effectiveness may be decreased by prochlorperazine syrup
  • Lithium because unexpected toxic effects may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if prochlorperazine syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use prochlorperazine syrup:

Use prochlorperazine syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take prochlorperazine syrup by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of prochlorperazine syrup, take it as soon as possible. If you are taking 1 dose at bedtime and do not remember until the next morning, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use prochlorperazine syrup.

Important safety information:

  • Prochlorperazine syrup may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use prochlorperazine syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Prochlorperazine syrup may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using prochlorperazine syrup; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Tell your doctor or dentist that you take prochlorperazine syrup before you receive any medical or dental care, emergency care, or surgery.
  • Prochlorperazine syrup may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to prochlorperazine syrup. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Avoid exposure to extreme heat while taking prochlorperazine syrup.
  • Patients who will be having spinal cord surgery should stop using prochlorperazine syrup at least 48 hours before surgery. Do not use prochlorperazine syrup for at least 24 hours after surgery and do not use it to control nausea and vomiting that has occurred before or after surgery.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by prochlorperazine syrup. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Use prochlorperazine syrup with caution in the ELDERLY; they may be more sensitive to its effects.
  • Prochlorperazine syrup should not be used in CHILDREN who are having surgery, who are younger than 2 years old, or who weigh less than 20 pounds; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using prochlorperazine syrup while you are pregnant. Prochlorperazine syrup is found in breast milk. If you are or will be breast-feeding while you use prochlorperazine syrup, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of prochlorperazine syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; chills; constipation; dizziness; drowsiness; dry mouth; jitteriness; nasal congestion; sleeplessness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; altered mental abilities, including lack of response to your surroundings; changes in breasts; changes in menstrual period; changes in vision; difficulty swallowing; drooling; excessive sweating; fever; inability to move eyes; increased body heat; involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements); irregular or fast heartbeat; mask-like face; muscle stiffness; muscle spasms of face, neck, or back; prolonged or painful erection; restlessness; rigid muscles; shuffling walk; sore throat; tension in legs; tremors; twitching or twisting movements; unusual eye movements; weakness of arms or legs; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching.

Proper storage of prochlorperazine syrup:

Store prochlorperazine syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep prochlorperazine syrup out of the reach of children and away from pets.

General information:

  • If you have any questions about prochlorperazine syrup, please talk with your doctor, pharmacist, or other health care provider.
  • Prochlorperazine syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about prochlorperazine syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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