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Generic Name: cilostazol (sye-LOE-sta-zol)
Brand Name: Pletal

Medicines similar to Pletal have shortened the lives of people with certain types of heart failure. Do not use Pletal if you have any type of heart failure.


Pletal is used for:

Reducing symptoms of intermittent claudication (pain, cramping, numbness, or weakness in the legs) that may occur with walking. It may also be used for other conditions as determined by your doctor.

Pletal is a phosphodiesterase type 3 inhibitor. Pletal works by widening blood vessels to increase blood flow. It also decreases the ability of platelets to stick together and form clots.

Do NOT use Pletal if:

  • you are allergic to any ingredient in Pletal
  • you have heart failure, bleeding problems or a disorder that causes the inability to form blood clots, or active bleeding (eg, bleeding peptic ulcer, bleeding in the brain)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Pletal:

Some medical conditions may interact with Pletal. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney problems, or low blood platelet levels
  • if you have a history of heart disease (eg, angina, heart attack)
  • if you have recently had surgery or any type of bleeding

Some MEDICINES MAY INTERACT with Pletal. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Clarithromycin, diltiazem, erythromycin, fluconazole, fluoxetine, indinavir, itraconazole, ketoconazole, nelfinavir, omeprazole, ritonavir, telithromycin, or ticlopidine because they may increase the risk of Pletal's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pletal may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pletal:

Use Pletal as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Pletal. Talk to your pharmacist if you have questions about this information.
  • Take Pletal by mouth at least 30 minutes before or 2 hours after eating.
  • Check with your doctor before you eat grapefruit or drink grapefruit juice while you take Pletal.
  • Pletal works best if it is taken at the same time(s) each day.
  • Continue to take Pletal even if you feel well. Do not miss any doses.
  • If you miss a dose of Pletal, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pletal.

Important safety information:

  • Tell your doctor or dentist that you take Pletal before you receive any medical or dental care, emergency care, or surgery.
  • Pletal may rarely reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Pletal may rarely lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • It may take several weeks to see Pletal's full effects. Discuss any questions or concerns with your doctor.
  • Lab tests may be performed while you take Pletal. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY AND BREAST-FEEDING: If you are pregnant or become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Pletal while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while you are taking Pletal.

Possible side effects of Pletal:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal stools; back pain; diarrhea; dizziness; headache; indigestion; nausea; runny nose; stomach pain; throat irritation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest, jaw, or left arm pain; fainting; fast or irregular heartbeat; severe or persistent dizziness or light-headedness; swelling of the hands, ankles, or feet; symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or that get bigger; or any bleeding that is severe or that you cannot stop); symptoms of infection (eg, fever, chills, sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, painful urination, mouth sores, wound that will not heal, anal itching or pain).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Pletal:

Store Pletal at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pletal out of the reach of children and away from pets.

General information:

  • If you have any questions about Pletal, please talk with your doctor, pharmacist, or other health care provider.
  • Pletal is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Pletal or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Pletal. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Pletal. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Pletal.

Issue Date: June 3, 2015
Database Edition 15.2.1.003
Copyright © 2015 Clinical Drug Information, LLC

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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