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Penicillin g benzathine/ penicillin g procaine suspension

Generic Name: penicillin g benzathine/penicillin g procaine (PEN-i-SIL-in G BEN-za-theen/PEN-i-SIL-in G PROE-kane)
Brand Name: Bicillin C-R

Do not inject penicillin g benzathine/penicillin g procaine suspension into or near an artery or vein. It should only be injected into a muscle. There have been reports of serious side effects, including death, when penicillin g benzathine/penicillin g procaine suspension has been injected into a vein.


Penicillin g benzathine/ penicillin g procaine suspension is used for:

Treating of some types of infections caused by certain bacteria.

Penicillin g benzathine/penicillin g procaine suspension is a penicillin antibiotic. It works by interfering with the formation of the bacteria's cell wall while it is growing. This weakens the cell wall and kills the bacteria.

Do NOT use penicillin g benzathine/ penicillin g procaine suspension if:

  • you are allergic to any ingredient in penicillin g benzathine/penicillin g procaine suspension or to other penicillins
  • you are taking a tetracycline antibiotic

Contact your doctor or health care provider right away if any of these apply to you.

Before using penicillin g benzathine/ penicillin g procaine suspension:

Some medical conditions may interact with penicillin g benzathine/penicillin g procaine suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have diarrhea or a stomach infection, especially in children 9 years old or younger

Some MEDICINES MAY INTERACT with penicillin g benzathine/penicillin g procaine suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Probenecid because it may increase the risk of penicillin g benzathine/penicillin g procaine suspension's side effects
  • Chloramphenicol or tetracycline antibiotics because they may decrease penicillin g benzathine/penicillin g procaine suspension's effectiveness
  • Anticoagulants (eg, warfarin), methotrexate, or succinylcholine because their actions and the risk of their side effects may be increased by penicillin g benzathine/penicillin g procaine suspension
  • Anticoagulants (eg, warfarin), chloramphenicol, or oral contraceptives (birth control pills) because their effectiveness may be decreased by penicillin g benzathine/penicillin g procaine suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if penicillin g benzathine/penicillin g procaine suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use penicillin g benzathine/ penicillin g procaine suspension:

Use penicillin g benzathine/penicillin g procaine suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Shake well before each use.
  • Penicillin g benzathine/penicillin g procaine suspension is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using penicillin g benzathine/penicillin g procaine suspension at home, a health care provider will teach you how to use it. Be sure you understand how to use penicillin g benzathine/penicillin g procaine suspension. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use penicillin g benzathine/penicillin g procaine suspension if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Penicillin g benzathine/penicillin g procaine suspension works best if it is given at the same time each day.
  • Penicillin g benzathine/penicillin g procaine suspension should not be injected into or near an artery or vein. Penicillin g benzathine/penicillin g procaine suspension should be injected into muscle, preferably in the upper outer portion of the buttocks. In children, penicillin g benzathine/penicillin g procaine suspension should be injected into the thigh.
  • To clear up your infection completely, use penicillin g benzathine/penicillin g procaine suspension for the full course of treatment. Keep using it even if you feel better in a few days.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of penicillin g benzathine/penicillin g procaine suspension, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use penicillin g benzathine/penicillin g procaine suspension.

Important safety information:

  • Penicillin g benzathine/penicillin g procaine suspension may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use penicillin g benzathine/penicillin g procaine suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Be sure to use penicillin g benzathine/penicillin g procaine suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Penicillin g benzathine/penicillin g procaine suspension only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Long-term or repeated use of penicillin g benzathine/penicillin g procaine suspension may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Diabetes patients - Penicillin g benzathine/penicillin g procaine suspension may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Use of penicillin g benzathine/penicillin g procaine suspension for prolonged or repeated periods of time may result in oral thrush, or a new yeast infection (eg, oral or vaginal fungal infections). Contact your health care provider if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using penicillin g benzathine/penicillin g procaine suspension. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Use penicillin g benzathine/penicillin g procaine suspension with caution in the ELDERLY; they may be more sensitive to its effects.
  • Use penicillin g benzathine/penicillin g procaine suspension with caution in NEWBORNS; they may be more sensitive to its effects.
  • PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using penicillin g benzathine/penicillin g procaine suspension while you are pregnant. Penicillin g benzathine/penicillin g procaine suspension is found in breast milk. If you are or will be breast-feeding while you use penicillin g benzathine/penicillin g procaine suspension, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of penicillin g benzathine/ penicillin g procaine suspension:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; drowsiness; mild diarrhea; nausea; pain, swelling, or redness at the injection site; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; bizarre behavior; blood in urine; bloody stools; chest pain; chills; confusion; extreme tiredness; fainting; fast heartbeat; fever; flushing with lightheadedness or fainting; hallucinations; headache; itching; muscle pain; pounding in the chest; rapid breathing; seizures; severe diarrhea; stomach pain/cramps; vaginal irritation or itching; worsening of skin lesions.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; confusion; convulsions; diarrhea; hallucinations; nausea; vomiting.

Proper storage of penicillin g benzathine/penicillin g procaine suspension:

Store penicillin g benzathine/penicillin g procaine suspension in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Dispose of properly after use. Keep penicillin g benzathine/penicillin g procaine suspension, as well as needles, syringes, or other materials, out of the reach of children and away from pets.

General information:

  • If you have any questions about penicillin g benzathine/penicillin g procaine suspension, please talk with your doctor, pharmacist, or other health care provider.
  • Penicillin g benzathine/penicillin g procaine suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take penicillin g benzathine/penicillin g procaine suspension or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about penicillin g benzathine/penicillin g procaine suspension. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to penicillin g benzathine/penicillin g procaine suspension. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using penicillin g benzathine/penicillin g procaine suspension.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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