Generic Name: oxymorphone (OX-i-MOR-fone)
Brand Name: Opana
Oxymorphone tablets are used for:
Treating moderate to severe pain in certain patients.
Oxymorphone tablets are an opioid (narcotic) analgesic. It works in the brain and nervous system to reduce pain.
Do NOT use oxymorphone tablets if:
- you are allergic to any ingredient in oxymorphone tablets or any other codeine- or morphine-related medicine (eg, oxycodone)
- you have difficult or slowed breathing, high levels of carbon dioxide in the blood (hypercapnia or hypercarbia), or severe asthma, or you are having an asthma attack
- you have moderate to severe liver problems
- you have known or suspected stomach or bowel blockage (eg, paralytic ileus)
- you are taking mixed agonist/antagonist analgesic medicines (eg, buprenorphine, butorphanol, nalbuphine, pentazocine) or sodium oxybate (GHB)
- you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using oxymorphone tablets:
Some medical conditions may interact with oxymorphone tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of chronic obstructive pulmonary disease (COPD) or other lung or breathing problems (eg, asthma, emphysema, bronchitis), sleep apnea, curvature of the spine (eg, kyphoscoliosis), heart problems (eg, cor pulmonale), hypercapnia or hypercarbia, low levels of oxygen in the blood (hypoxia), low blood pressure, dehydration, or low blood volume
- if you have severe drowsiness, a recent head injury, growths in the brain, increased pressure in the brain, or a history of seizures (eg, epilepsy)
- if you have liver or kidney problems, gallbladder or pancreas problems, adrenal gland problems (eg, Addison disease), thyroid problems, an enlarged prostate, a urinary blockage or trouble urinating, constipation, stomach pain, or stomach or bowel problems (eg, inflammation), or if you have had recent stomach or bowel surgery
- if you drink alcohol, have symptoms of alcohol withdrawal, or have a history of suicidal thoughts or attempts
- if you or a member of your family has a history of mental or mood problems (eg, anxiety, depression, hallucinations), or alcohol or other substance abuse or dependence
- if you have poor health or are in shock, are very overweight, or have recently had or will be having surgery
- if you are taking carisoprodol
Some MEDICINES MAY INTERACT with oxymorphone tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Phenothiazines (eg, chlorpromazine) because the risk of low blood pressure may be increased
- Cimetidine or sodium oxybate (GHB) because the risk of severe drowsiness, coma, confusion, or slowed or difficult breathing may be increased
- Anticholinergics (eg, scopolamine, benztropine) because the risk of severe constipation or trouble urinating may be increased
- MAOIs (eg, phenelzine) because the risk of a severe reaction, including fever, seizures, and coma, may be increased
- Mixed agonist/antagonist analgesics (eg, buprenorphine, butorphanol, nalbuphine, pentazocine) or naltrexone because they may decrease oxymorphone tablets's effectiveness and withdrawal may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if oxymorphone tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use oxymorphone tablets:
Use oxymorphone tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take oxymorphone tablets on an empty stomach at least 1 hour before or 2 hours after eating.
- Oxymorphone tablets must only be taken by mouth.
- If you have been taking oxymorphone tablets regularly, do not suddenly stop taking it. You may have an increased risk of withdrawal symptoms (eg, nausea, sweating, pain). If you need to stop oxymorphone tablets, your doctor will gradually lower your dose.
- If oxymorphone tablets are no longer needed, dispose of the unused medicine by flushing it down the toilet. You may also check with your pharmacist for other ways to dispose of oxymorphone tablets.
- Oxymorphone tablets are usually used as needed. If you forget to use a dose of oxymorphone tablets and you still have pain, use it when you remember as directed by your doctor. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use oxymorphone tablets.
Important safety information:
- Oxymorphone tablets may cause drowsiness, dizziness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol, other opiate pain medicines, or certain other medicines. Use oxymorphone tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol or take medicine (prescription or nonprescription) that contain alcohol while you take oxymorphone tablets. Check with your pharmacist if you have questions about whether any of your medicines contain alcohol.
- Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you take oxymorphone tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Oxymorphone tablets may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Oxymorphone tablets may be habit forming. Do NOT take more than the recommended dose, change your dose, use more often than prescribed, or use for longer than prescribed without checking with your doctor. Misuse or abuse of oxymorphone tablets may cause severe side effects, including severe breathing problems, seizures, coma, and possibly death.
- Oxymorphone tablets may cause constipation. Talk with your doctor or pharmacist about using a stool softener or laxative to prevent constipation. It is also important to maintain a diet adequate in fiber, drink plenty of water, and exercise to prevent constipation. If you become constipated while taking oxymorphone tablets, talk with your doctor or pharmacist.
- If your pain continues or becomes worse, or if you have side effects that concern you, contact your doctor.
- Tell your doctor or dentist that you take oxymorphone tablets before you receive any medical or dental care, emergency care, or surgery.
- Seek emergency medical care right away if another person swallows oxymorphone tablets. Accidental swallowing of oxymorphone tablets may be fatal, especially in children.
- Use oxymorphone tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially breathing problems, drowsiness, dizziness, confusion, and nausea.
- Oxymorphone tablets should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using oxymorphone tablets while you are pregnant. Long-term use of oxymorphone tablets during pregnancy may cause dependence in the fetus or newborn. Discuss any questions or concerns with your doctor. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use oxymorphone tablets, check with your doctor. Discuss any possible risks to your baby.
When used for long periods of time or at high doses, oxymorphone tablets may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if oxymorphone tablets stops working well. Do not take more than prescribed.
Some people who use oxymorphone tablets for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. Dependence is unlikely to be an issue in terminally ill patients when comfort is more important. If you are taking oxymorphone tablets regularly, do not suddenly stop taking it without checking with your doctor. WITHDRAWAL symptoms have occurred when oxymorphone tablets are suddenly stopped and may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; trouble sleeping; and vomiting. Contact your doctor if you notice any of these symptoms after stopping oxymorphone tablets.
Possible side effects of oxymorphone tablets:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; dizziness; drowsiness; dry mouth; gas; headache; mild itching; nausea; sweating; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; mental or mood changes (eg, agitation, depression); seizure; severe or persistent constipation, stomach pain, or vomiting; severe or persistent dizziness, drowsiness, or headache; shallow, slowed, or difficult breathing; shortness of breath; trouble urinating; unusual swelling; vision changes (eg, blurred vision).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish skin; chest, jaw, or arm pain; cold and clammy skin; coma; difficult, shallow, or slow breathing; fainting; limp muscles; pinpoint pupils; severe drowsiness or dizziness; shortness of breath; slow or irregular heartbeat; sudden, severe nausea or vomiting; sudden, unusual sweating or weakness.Proper storage of oxymorphone tablets:
Store oxymorphone tablets at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep oxymorphone tablets out of the reach of children and away from pets.
- If you have any questions about oxymorphone tablets, please talk with your doctor, pharmacist, or other health care provider.
- Oxymorphone tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take oxymorphone tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about oxymorphone tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to oxymorphone tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using oxymorphone tablets.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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