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Omeprazole/ sodium bicarbonate powder packets

Generic Name: omeprazole/sodium bicarbonate (oh-MEP-ra-zole/SOE-dee-um bye-KAR-bo-nate)
Brand Name: Zegerid

Omeprazole/ sodium bicarbonate powder packets is used for:

Treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may also be used for short-term treatment of ulcers of the stomach or small intestine. It may also be used to decrease the risk of stomach bleeding in severely ill patients. It may also be used for other conditions as determined by your doctor.

Omeprazole/sodium bicarbonate powder packets is a proton pump inhibitor (PPI) and sodium bicarbonate combination. The PPI works by decreasing the amount of acid produced in the stomach. The sodium bicarbonate works by slowing the breakdown of the PPI in the stomach, which helps to increase absorption of the PPI.

Do NOT use omeprazole/ sodium bicarbonate powder packets if:

  • you are allergic to any ingredient in omeprazole/sodium bicarbonate powder packets or to any other PPI (eg, esomeprazole)
  • you have low blood calcium levels or metabolic alkalosis
  • you are taking atazanavir, clopidogrel, dasatinib, nelfinavir, rifampin, rilpivirine, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update: First Time Brand-to-Generic Switches

Before using omeprazole/ sodium bicarbonate powder packets:

Some medical conditions may interact with omeprazole/sodium bicarbonate powder packets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems, heart failure, stomach or bowel cancer, or undiagnosed bleeding from the rectum
  • if you have Bartter syndrome; low blood potassium, calcium, or magnesium levels; acid-base balance problems; or respiratory alkalosis
  • if you are on a low-salt (sodium) diet
  • if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition)

Some MEDICINES MAY INTERACT with omeprazole/sodium bicarbonate powder packets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood magnesium levels may be increased
  • Voriconazole because it may increase the risk of omeprazole/sodium bicarbonate powder packets's side effects
  • Ginkgo biloba, rifampin, or St. John's wort because they may decrease omeprazole/sodium bicarbonate powder packets's effectiveness
  • Anticoagulants (eg, warfarin), benzodiazepines (eg, diazepam), cilostazol, citalopram, cyclosporine, digoxin, disulfiram, escitalopram, hydantoins (eg, phenytoin), methotrexate, saquinavir, or tacrolimus because the risk of their side effects may be increased by omeprazole/sodium bicarbonate powder packets
  • Ampicillin, atazanavir, bosutinib, clopidogrel, dasatinib, erlotinib, indinavir, iron, itraconazole, ketoconazole, mycophenolate, nelfinavir, nilotinib, posaconazole, rilpivirine, or sorafenib because their effectiveness may be decreased by omeprazole/sodium bicarbonate powder packets

This may not be a complete list of all interactions that may occur. Ask your health care provider if omeprazole/sodium bicarbonate powder packets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use omeprazole/ sodium bicarbonate powder packets:

Use omeprazole/sodium bicarbonate powder packets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Omeprazole/sodium bicarbonate powder packets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get omeprazole/sodium bicarbonate powder packets refilled.
  • Take omeprazole/sodium bicarbonate powder packets by mouth on an empty stomach at least 1 hour before a meal.
  • Place 1 to 2 tablespoons (15 to 30 mL) of water in a small cup. Do NOT use other liquids or foods. Empty the contents of the packet into the cup, stir well, and drink at once. Refill the cup with water and drink. Do not store the mixture for use at a later time.
  • If the patient is taking omeprazole/sodium bicarbonate powder packets through a nasogastric (NG) tube or gastric tube, follow the instructions for use in the extra patient leaflet.
  • You may take antacids while you are using omeprazole/sodium bicarbonate powder packets if you are directed to do so by your doctor.
  • Continue to take omeprazole/sodium bicarbonate powder packets even if you feel well. Do not miss any doses.
  • If you miss a dose of omeprazole/sodium bicarbonate powder packets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use omeprazole/sodium bicarbonate powder packets.

Important safety information:

  • Omeprazole/sodium bicarbonate powder packets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use omeprazole/sodium bicarbonate powder packets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Contact your doctor if you have any signs of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.
  • Do NOT change your dose, stop taking omeprazole/sodium bicarbonate powder packets, or take omeprazole/sodium bicarbonate powder packets for longer than prescribed without checking with your doctor.
  • Omeprazole/sodium bicarbonate powder packets may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor.
  • Omeprazole/sodium bicarbonate powder packets may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use omeprazole/sodium bicarbonate powder packets in high doses, for longer than a year, or if you are older than 50 years old. Contact your doctor if you have any questions about this information.
  • Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking omeprazole/sodium bicarbonate powder packets for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).
  • Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use omeprazole/sodium bicarbonate powder packets.
  • Omeprazole/sodium bicarbonate powder packets has sodium in it. Include this when you count your daily intake of sodium.
  • Long-term use of omeprazole/sodium bicarbonate powder packets with calcium or milk may cause milk-alkali syndrome. Check with your doctor before taking calcium supplements or antacids that contain calcium or drinking milk while you are taking omeprazole/sodium bicarbonate powder packets.
  • Both strengths of omeprazole/sodium bicarbonate powder packets contain the same amount of sodium bicarbonate. Therefore, if your doctor has prescribed the 40 mg dose, do not take 2 of the 20 mg packets to make a 40 mg dose.
  • Omeprazole/sodium bicarbonate powder packets may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking omeprazole/sodium bicarbonate powder packets.
  • Omeprazole/sodium bicarbonate powder packets should be used with extreme caution in Asian patients; the risk of side effects may be increased in these patients.
  • Use omeprazole/sodium bicarbonate powder packets with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures.
  • Omeprazole/sodium bicarbonate powder packets should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking omeprazole/sodium bicarbonate powder packets while you are pregnant. Omeprazole/sodium bicarbonate powder packets is found in breast milk. Do not breast-feed while taking omeprazole/sodium bicarbonate powder packets.

Possible side effects of omeprazole/ sodium bicarbonate powder packets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Gas; headache; mild diarrhea or stomach pain; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or watery stools; bone pain; change in the amount of urine produced; chest pain; confusion; dark urine; dizziness; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hand tremors; muscle twitching; numbness or tingling in the face, arms, or legs; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; stomach cramps; swelling of the hands, ankles, or feet; unexplained weight loss; unusual bruising or bleeding; unusual or sudden weight increase; unusual tiredness; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; dry mouth; fast heartbeat; flushing; increased sweating; seizures; severe headache, drowsiness, or nausea; vomiting.

Proper storage of omeprazole/sodium bicarbonate powder packets:

Store omeprazole/sodium bicarbonate powder packets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep omeprazole/sodium bicarbonate powder packets out of the reach of children and away from pets.

General information:

  • If you have any questions about omeprazole/sodium bicarbonate powder packets, please talk with your doctor, pharmacist, or other health care provider.
  • Omeprazole/sodium bicarbonate powder packets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take omeprazole/sodium bicarbonate powder packets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about omeprazole/sodium bicarbonate powder packets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to omeprazole/sodium bicarbonate powder packets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using omeprazole/sodium bicarbonate powder packets.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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