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Notuss-NXD liquid

Generic Name: codeine/chlorcyclizine/pseudoephedrine (KOE-deen/klor-SYE-klih-zeen/SOO-doe-e-FED-rin)
Brand Name: Examples include Notuss-NXD and Statuss Green

Some children have had serious and sometimes fatal breathing problems when using codeine after surgery to remove tonsils or adenoids. Talk with your doctor for more information.


Notuss-NXD liquid is used for:

Relieving symptoms of sinus congestion; runny nose; sneezing; itching of the nose or throat; itching, watery eyes; and cough caused by colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Notuss-NXD liquid is a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use Notuss-NXD liquid if:

  • you are allergic to any ingredient in Notuss-NXD liquid or any other codeine- or morphine-related medicine (eg, oxycodone)
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, severe heart problems
  • if you are unable to urinate or you are having an asthma attack
  • you take droxidopa, sodium oxybate (GHB), or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • the patient is a child and has just had surgery to remove tonsils or adenoids

Contact your doctor or health care provider right away if any of these apply to you.

Video: Asthma

How to prevent and treat an asthma attack.

Before using Notuss-NXD liquid:

Some medical conditions may interact with Notuss-NXD liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a recent head or brain injury, severe drowsiness, a brain tumor or lesion, increased pressure in the brain, an infection of the brain or nervous system, or a seizure disorder (eg, epilepsy)
  • if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems (eg, cor pulmonale; fast, slow, or irregular heartbeat; heart disease), high or low blood pressure, liver problems, low blood volume, diabetes, blood vessel problems, a stroke, glaucoma or increased pressure in the eye, or thyroid problems
  • if you have shortness of breath; a history of asthma, chronic cough, lung, or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea, slow or irregular breathing), or chronic obstructive pulmonary disease (COPD); or if your cough occurs with large amounts of mucus
  • if you have a history of constipation, stomach problems (eg, ulcers), bowel problems (eg, chronic inflammation, ulceration of the bowel, diarrhea due to antibiotic use), or gallbladder problems (eg, gallstones); a blockage of your stomach, bladder, or bowel; trouble urinating; an enlarged prostate or other prostate problems; or if you have had recent stomach, bowel, or urinary surgery
  • if you have a history of alcohol abuse, drug abuse, mental or mood problems (eg, depression), suicidal thoughts or behavior, or if you are in poor health or are very overweight
  • if you are taking medicine for high blood pressure or depression

Some MEDICINES MAY INTERACT with Notuss-NXD liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, scopolamine) because a serious bowel problem (paralytic ileus) may occur
  • Droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Beta-blockers (eg, propranolol), cimetidine, furazolidone, HIV protease inhibitors (eg, ritonavir), linezolid, MAOIs (eg, phenelzine), muscle relaxants (eg, cyclobenzaprine), opioid analgesics (eg, hydrocodone), sodium oxybate (GHB), tricyclic antidepressants (eg, amitriptyline), or urinary alkalinizers (eg, sodium bicarbonate) because they may increase the risk of Notuss-NXD liquid's side effects
  • Buprenorphine, naltrexone, quinidine, or rifamycins (eg, rifampin) because they may decrease Notuss-NXD liquid's effectiveness
  • Bromocriptine because the risk of its side effects may be increased by Notuss-NXD liquid
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Notuss-NXD liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Notuss-NXD liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Notuss-NXD liquid:

Use Notuss-NXD liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Notuss-NXD liquid by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Take Notuss-NXD liquid with a full glass of water (8 oz/240 mL).
  • Drink plenty of water while taking Notuss-NXD liquid.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of Notuss-NXD liquid and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Notuss-NXD liquid.

Important safety information:

  • Notuss-NXD liquid may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Notuss-NXD liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Notuss-NXD liquid may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Notuss-NXD liquid; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not take diet or appetite control medicines while you take Notuss-NXD liquid without checking with your doctor.
  • Before you start any new medicine, check the label to see if it has an antihistamine, cough suppressant, or a decongestant in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do not use Notuss-NXD liquid for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 5 to 7 days; get worse; or go away and then come back or occur with a fever, rash, or persistent headache, check with your doctor.
  • Notuss-NXD liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Notuss-NXD liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Notuss-NXD liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Notuss-NXD liquid for a few days before the tests.
  • Tell your doctor or dentist that you take Notuss-NXD liquid before you receive any medical or dental care, emergency care, or surgery.
  • Use Notuss-NXD liquid with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, low blood pressure, excitability, dry mouth, and trouble urinating.
  • Caution is advised when using Notuss-NXD liquid in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • Notuss-NXD liquid should not be used in CHILDREN younger than 12 years old without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Notuss-NXD liquid while you are pregnant. It is not known if Notuss-NXD liquid is found in breast milk. Do not breast-feed while taking Notuss-NXD liquid.

When used for long periods of time or at high doses, Notuss-NXD liquid may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Notuss-NXD liquid stops working well. Do not take more than prescribed.

When used for long periods of time or at high doses, some people develop a need to continue taking Notuss-NXD liquid. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Notuss-NXD liquid, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; trouble sleeping.

Possible side effects of Notuss-NXD liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating or inability to urinate; fainting; fast, slow, or irregular heartbeat; hallucinations; loss of coordination; mental or mood changes (eg, irritability); persistent trouble sleeping; restlessness; ringing in the ears; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; shallow breathing; tremor; uncontrolled muscle movements; unusual weakness or tiredness; vision changes or blurred vision.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; cold and clammy skin; coma; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Notuss-NXD liquid:

Store Notuss-NXD liquid at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Notuss-NXD liquid out of the reach of children and away from pets.

General information:

  • If you have any questions about Notuss-NXD liquid, please talk with your doctor, pharmacist, or other health care provider.
  • Notuss-NXD liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Notuss-NXD liquid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Notuss-NXD liquid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Notuss-NXD liquid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Notuss-NXD liquid.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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