Learn how to prepare for Severe Allergy Attacks.

NoHist-Plus controlled-release tablets

Generic Name: chlorpheniramine/phenylephrine/methscopolamine (KLOR-fen-IR-a-meen/FEN-il-EF-rin/METH-skoe-POL-a-meen)
Brand Name: Examples include Duravent-DA and NoHist-Plus

NoHist-Plus controlled-release tablets is used for:

Relieving nasal and chest congestion, sneezing, runny nose, and itchy, watery eyes due to colds, flu, or allergies. It is also used to make a dry cough more productive and less frequent. It may also be used for other conditions as determined by your doctor.

NoHist-Plus controlled-release tablets is an antihistamine, decongestant, and anticholinergic combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The anticholinergic works by drying mucous membranes in the nose and airway.

Do NOT use NoHist-Plus controlled-release tablets if:

  • you are allergic to any ingredient in NoHist-Plus controlled-release tablets
  • you are pregnant or breast-feeding
  • you are taking droxidopa, furazolidone, sodium oxybate (GHB), or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), or if you have taken an MAOI within the past 14 days
  • you have severe heart blood vessel problems, severe high blood pressure, narrow-angle glaucoma, difficulty urinating due to enlarged prostate, peptic ulcer, or uncontrolled bleeding
  • you are having an asthma attack
  • the patient is a newborn or infant

Contact your doctor or health care provider right away if any of these apply to you.

Before using NoHist-Plus controlled-release tablets:

Some medical conditions may interact with NoHist-Plus controlled-release tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are taking or have taken medicine for high blood pressure or depression in the last 14 days, or if you take potassium chloride
  • if you have bladder blockage, blood vessel problems (eg, hardening of the arteries), diabetes, an enlarged prostate, glaucoma or increased pressure in the eye, nerve problems, memory problems, heart problems (eg, fast or irregular heartbeat, heart failure), heart blood vessel problems, high blood pressure, kidney or liver problems, lung or breathing problems (eg, asthma, sleep apnea), a hiatal hernia, esophagus problems, stomach or bowel problems (eg, ulcerative colitis), mental or mood problems (eg, depression), an adrenal gland tumor (pheochromocytoma), myasthenia gravis (muscle weakness), stomach or bowel problems (eg, constipation, inflammation, motility problems, blockage), trouble sleeping, or an overactive thyroid
  • if the patient is a child who has Down syndrome, spastic paralysis, or brain damage
  • if you have a history of alcohol abuse or if you are very ill

Some MEDICINES MAY INTERACT with NoHist-Plus controlled-release tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Alkalizers (eg, calcium or magnesium antacids), alpha-blockers (eg, doxazosin), anesthetics (eg, chloroform, lidocaine), anticholinergics (eg, atropine, benztropine, dicyclomine), beta-blockers (eg, propranolol), carbonic anhydrase inhibitors (eg, acetazolamide), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), certain antidiarrheals (eg, bismuth subsalicylate), ergotamine, furazolidone, MAOIs (eg, phenelzine), sodium bicarbonate, or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of NoHist-Plus controlled-release tablets's side effects
  • Bromocriptine, certain stimulants (eg, doxapram, pseudoephedrine), digoxin, droxidopa, potassium chloride, or sodium oxybate (GHB) because the risk of their side effects may be increased by NoHist-Plus controlled-release tablets
  • Guanadrel, guanethidine, mecamylamine, methyldopa, reserpine, or other medicine for high blood pressure because their effectiveness may be decreased by NoHist-Plus controlled-release tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if NoHist-Plus controlled-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use NoHist-Plus controlled-release tablets:

This may not be a complete list of all interactions that may occur. Ask your health care provider if NoHist-Plus controlled-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

  • Take NoHist-Plus controlled-release tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow NoHist-Plus controlled-release tablets whole. Do not break, crush, or chew before swallowing. Some brands of NoHist-Plus controlled-release tablets may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.
  • Do not take NoHist-Plus controlled-release tablets at the same time as antacids, certain medicines for diarrhea (eg, attapulgite, bismuth, kaolin, pectin), or ketoconazole. Take these medicines 2 or 3 hours before or after taking NoHist-Plus controlled-release tablets.
  • If you miss a dose of NoHist-Plus controlled-release tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use NoHist-Plus controlled-release tablets.

Important safety information:

  • NoHist-Plus controlled-release tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use NoHist-Plus controlled-release tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using NoHist-Plus controlled-release tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • The risk of dizziness, nervousness, and trouble sleeping may be greater if you take NoHist-Plus controlled-release tablets in high doses or for a long time. Do NOT take more than the recommended dose without checking with your doctor.
  • If your cough or other symptoms persist for more than 1 week, if they come back, or if you also have fever, rash, or persistent headache, check with your doctor.
  • Tell your doctor or dentist that you take NoHist-Plus controlled-release tablets before you receive any medical or dental care, emergency care, or surgery.
  • NoHist-Plus controlled-release tablets may cause dry mouth. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.
  • NoHist-Plus controlled-release tablets may reduce sweating. Do not become overheated in hot weather or during exercise or other activities because heatstroke may occur.
  • NoHist-Plus controlled-release tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to NoHist-Plus controlled-release tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • NoHist-Plus controlled-release tablets may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • NoHist-Plus controlled-release tablets has phenylephrine and an antihistamine in it. Before you start any new medicine, check the label to see if it has phenylephrine or an antihistamine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Diabetes patients - NoHist-Plus controlled-release tablets may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
  • NoHist-Plus controlled-release tablets may interfere with certain lab test results. Be sure your doctors and laboratory personnel know that you are taking NoHist-Plus controlled-release tablets.
  • Lab tests, including blood pressure and eye pressure, may be performed while you use NoHist-Plus controlled-release tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use NoHist-Plus controlled-release tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially excitability, agitation, drowsiness, or confusion.
  • NoHist-Plus controlled-release tablets should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • Caution is advised when using NoHist-Plus controlled-release tablets in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • PREGNANCY and BREAST-FEEDING: It is not known if NoHist-Plus controlled-release tablets can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using NoHist-Plus controlled-release tablets while you are pregnant. NoHist-Plus controlled-release tablets is found in breast milk. If you are or will be breast-feeding while you use NoHist-Plus controlled-release tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of NoHist-Plus controlled-release tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; drowsiness; dry mouth, nose, or throat; excitability or irritability (especially in children); giddiness; headache; lightheadedness; loss of appetite; nausea; nervousness; stomach upset; trouble sleeping; unsteadiness; unusual tiredness or weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fast or irregular heartbeat; fever or sore throat; flushing; hallucinations; mental or mood changes; seizures; severe drowsiness; severe sunburn; shortness of breath; tingling in hands or feet; tremor; unusual bruising or bleeding; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include hallucinations; irregular heartbeat; mental or mood changes (eg, anxiety, confusion); pupil enlargement; seizure; severe dizziness, drowsiness, headache, nausea, or vomiting; tremor; trouble swallowing.

Proper storage of NoHist-Plus controlled-release tablets:

Store NoHist-Plus controlled-release tablets in a tightly closed container between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat and light. Keep NoHist-Plus controlled-release tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about NoHist-Plus controlled-release tablets, please talk with your doctor, pharmacist, or other health care provider.
  • NoHist-Plus controlled-release tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take NoHist-Plus controlled-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about NoHist-Plus controlled-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to NoHist-Plus controlled-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using NoHist-Plus controlled-release tablets.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about Nohist Plus (chlorpheniramine / methscopolamine / phenylephrine)

Consumer resources

Other formulations

Related treatment guides

Hide
(web4)