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Nitrostat

Pronunciation

Generic Name: nitroglycerin (NYE-troe-GLIS-er-in)
Brand Name: Nitrostat

Nitrostat is used for:

Preventing or relieving a sudden attack of angina (chest pain) caused by heart disease. It may also be used for other conditions as determined by your doctor.

Nitrostat is a nitrate. It works by dilating (widening) blood vessels. Chest pain occurs when the heart needs more oxygen than it can get. Dilating blood vessels allows blood to flow more easily. This reduces the heart's workload and the amount of oxygen needed by the heart.

Do NOT use Nitrostat if:

  • you are allergic to any ingredient in Nitrostat
  • you have increased pressure in the head
  • you have severe anemia
  • you are also taking a phosphodiesterase type 5 (PDE5) inhibitor (eg, sildenafil, tadalafil, vardenafil)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nitrostat:

Some medical conditions may interact with Nitrostat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you drink alcoholic beverages
  • if you have a history of other heart problems (eg, heart failure, an enlarged heart, a heart attack), an overactive thyroid, a stroke or other bleeding in the brain, or a recent head injury
  • if you have anemia, low blood pressure, dehydration, or low blood volume

Some MEDICINES MAY INTERACT with Nitrostat. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), calcium channel blockers (eg, diltiazem), diuretics (eg, furosemide, hydrochlorothiazide), medicines for high blood pressure, PDE5 inhibitors (eg, sildenafil), or phenothiazines (eg, thioridazine) because the risk of low blood pressure and dizziness when standing may be increased
  • Salicylates (eg, aspirin) because they may increase the risk of Nitrostat's side effects
  • Long-acting nitrates (eg, nitroglycerin patch) because they may decrease Nitrostat's effectiveness
  • Ergot alkaloids (eg, dihydroergotamine, ergotamine) because the risk of their side effects may be increased by Nitrostat
  • Alteplase because its effectiveness may be decreased by Nitrostat

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nitrostat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nitrostat:

Use Nitrostat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Do NOT swallow, chew, or crush this tablet. Dissolve the tablet under the tongue or between the cheek and gum.
  • To treat an angina attack, use Nitrostat at the first sign of chest pain. Sit quietly while the tablet is dissolving. The dose may be repeated every 5 minutes until you get relief or as directed by your doctor. Do not use more than 3 tablets in 15 minutes. If chest pain continues after a total of 3 tablets, seek medical attention at once, unless your doctor gives you different instructions.
  • If you use Nitrostat to prevent angina caused by physical activity, use it 5 to 10 minutes before activity unless your doctor tells you otherwise.
  • If you miss a dose of Nitrostat and you are still having chest pain, contact your doctor right away. Ask your health care provider any questions you may have about the proper use of Nitrostat.

Ask your health care provider any questions you may have about how to use Nitrostat.

Important safety information:

  • Nitrostat may cause dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Nitrostat with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol while you are using Nitrostat. Drinking alcohol may increase the risk of low blood pressure with Nitrostat.
  • Nitrostat may cause dizziness, lightheadedness, or fainting. Sit down while taking Nitrostat. When you return to a standing position, stand slowly using caution to avoid falling caused by lightheadedness or dizziness.
  • Nitrostat can cause tingling or burning when you put it under your tongue. However, lack of tingling or burning does not mean the medicine is not working.
  • Contact your doctor right away if you develop slow heartbeat or new or worsening chest pain after you take Nitrostat.
  • Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.
  • Keep medicine in the original glass bottle with the cap tightly closed.
  • Tell your doctor or dentist that you take Nitrostat before you receive any medical or dental care, emergency care, or surgery.
  • Nitrostat may interfere with certain lab tests, including certain cholesterol tests. Be sure your doctor and lab personnel know you are using Nitrostat.
  • Lab tests, including heart function, blood pressure, and blood electrolyte levels, may be performed while you take Nitrostat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Nitrostat with caution in the ELDERLY; they may be more sensitive to its effects.
  • Nitrostat should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Nitrostat while you are pregnant. It is not known if Nitrostat is found in breast milk. If you are or will be breast-feeding while you are taking Nitrostat, check with your doctor. Discuss any possible risks to your baby.

When used at higher doses or more often than prescribed, Nitrostat may not work as well. This is known as TOLERANCE. Tolerance to other nitrates and nitrites may also occur. Increasing the dose is not effective in managing tolerance to Nitrostat. Talk with your doctor if Nitrostat stops working well. Do not take more than prescribed.

Possible side effects of Nitrostat:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning or tingling sensation; dizziness, lightheadedness, or fainting when sitting up or standing; flushing of the face and neck; headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; dry mouth; fainting; flushing; heavy sweating; new, abnormal, or worsening chest pain; pale skin; pounding in the chest; severe dizziness or headache; severe or persistent nausea or vomiting; shortness of breath; slow or irregular heartbeat; swelling of the hands, ankles, or feet; unusual weakness; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include cold or blue skin; confusion; diarrhea; excessive sweating; fainting; fast, slow, or irregular heartbeat; fever; inability to move; loss of consciousness; persistent throbbing headache; seizures; severe dizziness, nausea, or vomiting; trouble breathing; vision problems.

Proper storage of Nitrostat:

Store Nitrostat in the original glass container, tightly closed, at or below 77 degrees F (25 degrees C). Protect from heat, moisture, and light. Do not store in bathroom. Keep Nitrostat out of the reach of children and away from pets.

General information:

  • If you have any questions about Nitrostat, please talk with your doctor, pharmacist, or other health care provider.
  • Nitrostat is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Nitrostat or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Nitrostat. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Nitrostat. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Nitrostat.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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