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Nitroglycerin controlled-release capsules

Pronunciation

Generic Name: nitroglycerin (NYE-troe-GLIS-er-in)
Brand Name: Nitro-Time

Nitroglycerin controlled-release capsules is used for:

Preventing chronic chest pain caused by heart disease. It also may be used for other conditions as determined by your doctor.

Nitroglycerin controlled-release capsules is a nitrate. It works by relaxing (widening) blood vessels. Chest pain occurs when the heart needs more oxygen than it can get. Relaxing blood vessels allows blood to flow more easily. This reduces the heart's workload and the amount of oxygen needed by the heart.

Do NOT use nitroglycerin controlled-release capsules if:

  • you are allergic to any ingredient in nitroglycerin controlled-release capsules
  • you have increased pressure in or severe injury to the head
  • you have severe anemia
  • you are taking avanafil, riociguat, sildenafil, tadalafil, or vardenafil

Contact your doctor or health care provider right away if any of these apply to you.

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Before using nitroglycerin controlled-release capsules:

Some medical conditions may interact with nitroglycerin controlled-release capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you drink alcoholic beverages
  • if you have a history of other heart problems (eg, heart failure, enlarged heart, heart attack), overactive thyroid, stroke or other bleeding in the brain, or recent head injury
  • if you have anemia, low blood pressure, dehydration, or low blood volume

Some MEDICINES MAY INTERACT with nitroglycerin controlled-release capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Avanafil, beta-blockers (eg, propranolol), calcium channel blockers (eg, diltiazem), diuretics (eg, furosemide, hydrochlorothiazide), medicines for high blood pressure, phenothiazines (eg, thioridazine), riociguat, sildenafil, tadalafil, or vardenafil because the risk of low blood pressure and dizziness on standing may be increased
  • Salicylates (eg, aspirin) because they may increase the risk of nitroglycerin controlled-release capsules's side effects
  • Alteplase because the effectiveness of nitroglycerin controlled-release capsules may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if nitroglycerin controlled-release capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use nitroglycerin controlled-release capsules:

Use nitroglycerin controlled-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take nitroglycerin controlled-release capsules by mouth with or without food.
  • Swallow nitroglycerin controlled-release capsules whole. Do not break, crush, or chew before swallowing.
  • Nitroglycerin controlled-release capsules lasts for about 12 hours. Do not take more of nitroglycerin controlled-release capsules than prescribed. It is important to have a "nitrate-free" period of time for 10 to 12 hours each day for nitroglycerin controlled-release capsules to continue to work well and to decrease the risk of physical dependence.
  • If you miss a dose of nitroglycerin controlled-release capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use nitroglycerin controlled-release capsules.

Important safety information:

  • Nitroglycerin controlled-release capsules may cause dizziness, light-headedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use nitroglycerin controlled-release capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol while you are taking nitroglycerin controlled-release capsules. Drinking alcohol may increase the risk of low blood pressure with nitroglycerin controlled-release capsules.
  • Nitroglycerin controlled-release capsules may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Contact your doctor right away if you develop slow heartbeat or new or worsening chest pain after you take nitroglycerin controlled-release capsules.
  • Tell your doctor or dentist that you take nitroglycerin controlled-release capsules before you receive any medical or dental care, emergency care, or surgery.
  • Nitroglycerin controlled-release capsules may give you daily headaches. This should become less noticeable with time. Do not change how you use nitroglycerin controlled-release capsules to avoid these headaches. Talk with your doctor for ways to lessen this side effect.
  • Other dosage forms of nitroglycerin controlled-release capsules (eg, sublingual, or under the tongue, tablets) may not work as well while you are taking nitroglycerin controlled-release capsules.
  • Nitroglycerin controlled-release capsules takes about 1 to 2 hours to start working and should not be used for a sudden chest pain attack.
  • You may need to check your blood pressure often while using nitroglycerin controlled-release capsules. Talk with your doctor.
  • Use nitroglycerin controlled-release capsules with caution in the ELDERLY; they may be more sensitive to its effects.
  • Nitroglycerin controlled-release capsules is not recommended for use in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using nitroglycerin controlled-release capsules while you are pregnant. It is not known if nitroglycerin controlled-release capsules is found in breast milk. If you are or will be breast-feeding while you are using nitroglycerin controlled-release capsules, check with your doctor. Discuss any possible risks to your baby.

When used for long periods of time without a break, nitroglycerin controlled-release capsules may not work as well. This is known as TOLERANCE. Increasing the dose is not effective in managing tolerance to nitroglycerin controlled-release capsules. Tolerance to other nitrates or nitrites may also occur. Be sure to have a "nitrate-free" period of time each day to help prevent this tolerance. Talk with your doctor if nitroglycerin controlled-release capsules stops working well. Do not take more than prescribed.

Some people who use nitroglycerin controlled-release capsules for a long time without a break may develop a physical need to continue taking it. This is known as physical DEPENDENCE. If you use nitroglycerin controlled-release capsules without a break and then suddenly stop using it, you may get WITHDRAWAL symptoms. These may include chest pain, heart attack, or possibly sudden death. Be sure to have a "nitrate-free" period of time each day; this may help prevent dependence and withdrawal problems.

Possible side effects of nitroglycerin controlled-release capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness or light-headedness; headache.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; dry mouth; fainting; fast or irregular heartbeat; flushing; heavy sweating; pale skin; restlessness; severe or persistent dizziness or headache; severe or persistent nausea or vomiting; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of nitroglycerin controlled-release capsules:

Store nitroglycerin controlled-release capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep nitroglycerin controlled-release capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about nitroglycerin controlled-release capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Nitroglycerin controlled-release capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take nitroglycerin controlled-release capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about nitroglycerin controlled-release capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to nitroglycerin controlled-release capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using nitroglycerin controlled-release capsules.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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