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Nitroglycerin aerosol

Pronunciation

Generic Name: nitroglycerin (NYE-troe-GLIS-er-in)
Brand Name: NitroMist

Nitroglycerin aerosol is used for:

Preventing or relieving a sudden attack of angina (chest pain) caused by heart disease. It may also be used for other conditions as determined by your doctor.

Nitroglycerin aerosol is a nitrate. It works by dilating (widening) blood vessels. Chest pain occurs when the heart needs more oxygen than it can get. Dilating blood vessels allows blood to flow more easily. This reduces the heart's workload and the amount of oxygen needed by the heart.

Do NOT use nitroglycerin aerosol if:

  • you are allergic to any ingredient in nitroglycerin aerosol, to other nitrates (eg, isosorbide mononitrate), or to nitrites
  • you have severe anemia or increased pressure in the head
  • you are also taking a phosphodiesterase type 5 inhibitor (eg, sildenafil, tadalafil, vardenafil)

Contact your doctor or health care provider right away if any of these apply to you.

Before using nitroglycerin aerosol:

Some medical conditions may interact with nitroglycerin aerosol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of other heart problems (eg, heart failure, enlarged heart, heart attack), overactive thyroid, stroke or other bleeding in the brain, or recent head injury
  • if you have anemia, low blood pressure, dehydration, or low blood volume
  • if you drink alcoholic beverages

Some MEDICINES MAY INTERACT with nitroglycerin aerosol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), calcium channel blockers (eg, diltiazem), diuretics (eg, furosemide, hydrochlorothiazide), medicines for high blood pressure, phenothiazines (eg, thioridazine), or phosphodiesterase type 5 inhibitors (eg, sildenafil, tadalafil, vardenafil) because the risk of low blood pressure and dizziness on standing may be increased
  • Salicylates (eg, aspirin) because they may increase the risk of nitroglycerin aerosol's side effects
  • Long-acting nitrates (eg, nitroglycerin patch) because they may decrease nitroglycerin aerosol's effectiveness
  • Ergot derivatives (eg, ergotamine, dihydroergotamine) because the risk of their side effects may be increased by nitroglycerin aerosol
  • Alteplase because its effectiveness may be decreased by nitroglycerin aerosol

This may not be a complete list of all interactions that may occur. Ask your health care provider if nitroglycerin aerosol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use nitroglycerin aerosol:

Use nitroglycerin aerosol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with nitroglycerin aerosol. Talk to your pharmacist if you have questions about this information.
  • Do NOT shake nitroglycerin aerosol.
  • Do NOT inhale the spray. Nitroglycerin aerosol is to be used on or under the tongue.
  • Before using the medicine for the first time, prime the pump by spraying 10 times into the air away from yourself and others. If you do not use nitroglycerin aerosol within 6 weeks, reprime by spraying twice into the air.
  • To use nitroglycerin aerosol, remove the plastic cover. Hold the container upright with your forefinger on top of the grooved button. Open your mouth and bring the container as close to your mouth as possible. Press the button firmly to release the spray onto or under your tongue. Release the button and close your mouth after each dose.
  • Replace the plastic cover after you are finished using nitroglycerin aerosol.
  • Do not swallow right away after you use a dose. Do not spit or rinse your mouth for 5 to 10 minutes after you use nitroglycerin aerosol.
  • To treat an angina attack, use 1 to 2 sprays on or under the tongue as directed by your doctor. Sit quietly after using a dose. A spray may be repeated approximately every 5 minutes as directed by your doctor. Do not use more than 3 sprays in 15 minutes unless your doctor tells you otherwise. If chest pain continues after a total of 3 sprays, seek medical attention at once, unless your doctor gives you different instructions.
  • If you use nitroglycerin aerosol to prevent angina caused by physical activity, use it 5 to 10 minutes before activity unless your doctor tells you otherwise.
  • Check the level of fluid in your container regularly. While the container is in the upright position, if the fluid level reaches the top or middle of the hole on the side of the container, you should get a refill of nitroglycerin aerosol.
  • If you miss a dose of nitroglycerin aerosol and you are still having chest pain, contact your doctor right away. Ask your health care provider any questions you may have about the proper use of nitroglycerin aerosol.

Ask your health care provider any questions you may have about how to use nitroglycerin aerosol.

Important safety information:

  • Nitroglycerin aerosol may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use nitroglycerin aerosol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol while you are using nitroglycerin aerosol. Drinking alcohol may increase the risk of low blood pressure with nitroglycerin aerosol.
  • Nitroglycerin aerosol may cause dizziness, light-headedness, or fainting. Sit down while taking nitroglycerin aerosol to avoid falling caused by light-headedness or dizziness.
  • Contact your doctor right away if you develop slow heartbeat or new or worsening chest pain after you take nitroglycerin aerosol.
  • The risk of tolerance to nitroglycerin aerosol may be greater if you take nitroglycerin aerosol in high doses or more often than prescribed. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.
  • Nitroglycerin aerosol is flammable. Do not store or use near an open flame. Do not force open or burn the container.
  • Tell your doctor or dentist that you take nitroglycerin aerosol before you receive any medical or dental care, emergency care, or surgery.
  • Nitroglycerin aerosol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using nitroglycerin aerosol while you are pregnant. It is not known if nitroglycerin aerosol is found in breast milk. If you are or will be breast-feeding while you are using nitroglycerin aerosol, check with your doctor. Discuss any possible risks to your baby.

When used at higher doses or more often than prescribed, nitroglycerin aerosol may not work as well. This is known as TOLERANCE. Tolerance to other nitrates and nitrites may also occur. Increasing the dose is not effective in managing tolerance to nitroglycerin aerosol. Talk with your doctor if nitroglycerin aerosol stops working well. Do not take more than prescribed.

Possible side effects of nitroglycerin aerosol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; light-headedness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; dry mouth; fainting; fast, slow, or irregular heartbeat; flushing; heavy sweating; nausea; new or worsening chest pain; pale skin; redness or scaling of the skin; severe or persistent dizziness, light-headedness, or headache; shortness of breath; swelling of the hands, ankles, or feet; unusual weakness; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include changes in vision; cold and clammy skin; confusion; dizziness; fainting; fast, slow, or irregular heartbeat; fever; flushing; light-headedness; nausea; paralysis; persistent, throbbing headache; seizures; shortness of breath; sweating; vomiting; weakness.

Proper storage of nitroglycerin aerosol:

Store nitroglycerin aerosol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Protect from heat, moisture, and light. Do not store in bathroom. Keep nitroglycerin aerosol out of the reach of children and away from pets.

General information:

  • If you have any questions about nitroglycerin aerosol, please talk with your doctor, pharmacist, or other health care provider.
  • Nitroglycerin aerosol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take nitroglycerin aerosol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about nitroglycerin aerosol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to nitroglycerin aerosol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using nitroglycerin aerosol.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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