Navelbine

Generic Name: vinorelbine (vi-NOR-el-been)
Brand Name: Navelbine

If Navelbine accidentally leaks into surrounding tissue, the skin and/or muscle may be severely damaged. Notify your doctor immediately if you feel pain or irritation at the injection site. Fatalities have occurred when medicines similar to vinorelbine were injected into the spine. This drug is for intravenous (IV; into a vein) use only.

Navelbine can cause blood disorders (eg, granulocytopenia) than can decrease your ability to fight infection. Notify your doctor immediately if you develop signs of infection, such as persistent sore throat or fever.


Navelbine is used for:

Treating cancer.

Navelbine is an antineoplastic. It works by targeting cancer cells and interfering with their reproduction.

Do NOT use Navelbine if:

  • you are allergic to any ingredient in Navelbine
  • you have chickenpox or certain blood problems (eg, low granulocyte counts)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Navelbine:

Some medical conditions may interact with Navelbine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems, bone marrow problems or disease, or a history of blood problems, including those caused by chemotherapy
  • if you have received radiation therapy or you are using other types of chemotherapy (eg, mitomycin, cisplatin)

Some MEDICINES MAY INTERACT with Navelbine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cisplatin, cyclosporin, itraconazole, mitomycin, paclitaxel, or streptogramins (eg, quinupristin) because the side effects of Navelbine may be increased
  • Digoxin or hydantoins (eg, phenytoin) because their effectiveness may be decreased by Navelbine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Navelbine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Navelbine:

Use Navelbine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Navelbine is usually administered as an injection at your doctor's office, hospital, or clinic.
  • If Navelbine contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Navelbine, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Navelbine.

Important safety information:

  • Navelbine may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
  • Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking Navelbine. Vaccinations may be less effective.
  • LAB TESTS, including complete blood counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Navelbine is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Navelbine has been shown to cause harm to the fetus. Avoid becoming pregnant while taking Navelbine. If you think you may be pregnant, discuss with your doctor the benefits and risks of using Navelbine during pregnancy. It is unknown if Navelbine is excreted in breast milk. Do not breast-feed while taking Navelbine.

Possible side effects of Navelbine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; nausea; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; constipation; cough; numbness or tingling of your fingers or toes; pain, redness, or swelling at the injection site; shortness of breath; stomach pain; unusual bleeding or bruising.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Navelbine:

Navelbine is usually handled and stored by a health care provider. If you are using Navelbine at home, store Navelbine as directed by your pharmacist or health care provider. Keep Navelbine out of the reach of children and away from pets.

General information:

  • If you have any questions about Navelbine, please talk with your doctor, pharmacist, or other health care provider.
  • Navelbine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Navelbine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Navelbine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Navelbine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Navelbine.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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