Morphine suspension

Generic Name: morphine (MOR-feen)
Brand Name: DepoDur

Morphine suspension is used for:

Treating pain following surgery. It may also be used for other conditions as determined by your doctor.

Morphine suspension is a narcotic pain reliever. It works in the brain to decrease pain. It may also affect other body systems (eg, breathing and circulatory systems) at higher doses.

Do NOT use morphine suspension if:

  • you are allergic to any ingredient in morphine suspension
  • you have severe diarrhea, bowel problems caused by antibiotics or food poisoning, a blockage of your stomach or bowel, or certain other severe bowel problems (eg, bowel paralysis)
  • you have difficult or slowed breathing, severely decreased blood circulation (circulatory shock), a recent head injury, growths in the brain (eg, tumors), or increased pressure in the brain
  • if you have severe asthma, or if you are having an asthma attack
  • you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or if you have taken an MAOI within the past 14 days
  • you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using morphine suspension:

Some medical conditions may interact with morphine suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of lung or breathing problems (eg, asthma, emphysema, bronchitis, chronic obstructive pulmonary disease [COPD]), sleep apnea (you stop breathing when you sleep), curvature of the spine (eg, kyphoscoliosis), heart problems (eg, cor pulmonale), low blood pressure, dehydration, or low blood volume
  • if you have liver problems, kidney problems, adrenal gland problems (eg, Addison disease), an underactive thyroid, a blockage of your bladder, an enlarged prostate, or trouble urinating
  • if you have a history of bowel blockage or other stomach or bowel problems (eg, inflammation), pancreas or gallbladder problems, or recent stomach or bowel surgery
  • if you have severe drowsiness or a history of seizures (eg, epilepsy)
  • if you drink alcohol regularly, have symptoms of alcohol withdrawal, or have a history of suicidal thoughts or attempts
  • if you have a personal or family history of mental or mood problems, alcohol abuse, or other substance abuse or dependence
  • if you are in poor health or are overweight

Some MEDICINES MAY INTERACT with morphine suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiemetics (eg, metoclopramide), phenothiazines (eg, chlorpromazine), sleeping medicines (eg, zolpidem), or tranquilizers (eg, olanzapine) because the risk of breathing problems, low blood pressure, severe drowsiness, or coma may be increased
  • Barbiturate anesthetics (eg, thiopental), cimetidine, MAOIs (eg, phenelzine), muscle relaxants (eg, carisoprodol), or sodium oxybate (GHB) because the risk of confusion, severe drowsiness, severe breathing problems, and coma may be increased
  • Mixed narcotic agonists/antagonists (eg, pentazocine), naltrexone, or rifampin because they may decrease morphine suspension's effectiveness
  • Diuretics (eg, furosemide, hydrochlorothiazide) or trovafloxacin because their effectiveness may be decreased by morphine suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if morphine suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use morphine suspension:

Use morphine suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Morphine suspension is usually given as an injection at your doctor's office, hospital, or clinic.
  • If you miss a dose of morphine suspension contact your doctor.

Ask your health care provider any questions you may have about how to use morphine suspension.

Important safety information:

  • Morphine suspension may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use morphine suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using morphine suspension.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using morphine suspension; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Morphine suspension may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Tell your doctor or dentist that you received morphine suspension before you have any medical or dental care, emergency care, or surgery.
  • Lab tests, including liver function, kidney function, lung function, and complete blood cell counts, may be performed while you use morphine suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use morphine suspension with caution in the ELDERLY; they may be more sensitive to its effects, especially severe breathing problems.
  • Morphine suspension should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using morphine suspension while you are pregnant. Morphine suspension is found in breast milk. Check with your doctor to see whether or not you should breast-feed within 48 hours after receiving morphine suspension.

When used for long periods of time or at high doses, morphine suspension may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if morphine suspension stops working well. Do not take more than prescribed.

Some people who use morphine suspension for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you stop taking morphine suspension suddenly, you may have WITHDRAWAL symptoms. These may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of morphine suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; headache; lightheadedness; nausea; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; delirium; difficulty urinating; disorientation; fainting; fast, slow, or irregular heartbeat; fever; flushing of the face; hallucinations; mood or mental changes; numbness or tingling; seizures; severe dizziness or lightheadedness; severe drowsiness; severe or persistent vomiting or constipation, shortness of breath; slowed or difficult breathing; tremor; trouble sleeping; unusual sweating; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include cold and clammy skin; convulsions; deep sleep; dizziness; lightheadedness; loss of consciousness; severe drowsiness; slowed breathing; slowed heartbeat.

Proper storage of morphine suspension:

Morphine suspension is usually handled and stored by a health care provider. If you are using morphine suspension at home, store morphine suspension as directed by your pharmacist or health care provider.

General information:

  • If you have any questions about morphine suspension, please talk with your doctor, pharmacist, or other health care provider.
  • Morphine suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take morphine suspension or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about morphine suspension. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to morphine suspension. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using morphine suspension.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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