Morphine solution

Pronunciation

Generic Name: morphine (MORE-feen)
Brand Name: Generic only. No brands available.

Keep morphine solution out of the reach of children and away from pets. Seek emergency medical attention immediately if accidental ingestion occurs.


Morphine solution is used for:

Treating moderate to severe pain.

Morphine solution is a narcotic pain reliever. It works in the brain and the nervous system to decrease pain.

Do NOT use morphine solution if:

  • you are allergic to any ingredient in morphine solution
  • you have known or suspected bowel blockage (eg, paralytic ileus)
  • you have severe or persistent diarrhea associated with antibiotic use (pseudomembranous colitis)
  • you have slow or difficult breathing, severe asthma, severe hypercarbia or hypercapnia (high blood levels of carbon dioxide), or you are having an asthma attack
  • you are taking sodium oxybate (GHB) or you drink alcohol
  • you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), or you have taken one within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

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Before using morphine solution:

Some medical conditions may interact with morphine solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, especially other narcotic pain relievers (eg, codeine, hydromorphone); foods; or other substances
  • if you have asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems
  • if you have increased pressure in the head, a recent head injury, or growths in the brain (eg, tumors, lesions)
  • if you have a history of heart problems (eg, cor pulmonale), liver or kidney problems, thyroid problems, stomach or bowel problems (eg, constipation, blockage, inflammation), gallbladder or pancreas problems, prostate problems, trouble urinating, adrenal gland problems (eg, Addison disease), hypoxia (not enough oxygen in your body), hypercapnia or hypercarbia, curvature of the spine, or seizures
  • if you have a history of mental or mood problems (eg, depression), hallucinations, suicidal thoughts or actions, or alcohol or other substance abuse or dependence
  • if you will be having surgery or you are currently having alcohol withdrawal
  • if you have severe drowsiness; low blood volume; stomach pain; very poor health; have had stomach or intestinal surgery; or you are in shock caused by heart problems, blood vessel problems, or severe bleeding

Some MEDICINES MAY INTERACT with morphine solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Mixed narcotic agonists/antagonists (eg, buprenorphine, butorphanol, pentazocine) or naltrexone because they may decrease morphine solution's effectiveness and withdrawal symptoms may occur
  • Fluoxetine, rifamycins (eg, rifampin), or risperidone because they may decrease morphine solution's effectiveness
  • Cimetidine, ketorolac, or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects, such as severe drowsiness, slow or difficulty breathing, confusion, and seizures, may be increased
  • Anticholinergics (eg, oxybutynin, scopolamine), antihistamines (eg, diphenhydramine), antinausea medicines (eg, ondansetron), benzodiazepines (eg, lorazepam), MAOIs (eg, phenelzine), other narcotic pain medicines (eg, hydrocodone), phenothiazines (eg, chlorpromazine), quinidine, sleep medicines (eg, zolpidem), or sodium oxybate (GHB) because they may increase the risk of morphine solution's side effects
  • Skeletal muscle relaxants (eg, cyclobenzaprine) because the risk of their side effects may be increased
  • Mexiletine or trovafloxacin because their effectiveness may be decreased by morphine solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if morphine solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use morphine solution:

Use morphine solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Morphine solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get morphine solution refilled.
  • Take morphine solution by mouth with or without food.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If morphine solution is no longer needed, dispose of it as soon as possible. Ask your doctor or pharmacist how to dispose of morphine solution properly.
  • If you miss a dose of morphine solution and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use morphine solution.

Important safety information:

  • Morphine solution may cause dizziness, drowsiness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use morphine solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are taking morphine solution.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using morphine solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Morphine solution may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Morphine solution may cause constipation. To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. Talk to your doctor about using fiber laxatives or stool softeners to prevent or treat constipation while you use morphine solution.
  • The risk of morphine solution becoming habit-forming may be greater if you take it in high doses or for a long time. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Do NOT change your dose or use more often than prescribed without checking with your doctor.
  • Do NOT suddenly stop taking morphine solution without checking with your doctor. If you have been taking morphine solution for more than a few weeks and your doctor tells you to stop using morphine solution, your dose may need to be gradually lowered as directed by your doctor to avoid side effects.
  • Tell your doctor or dentist that you take morphine solution before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including liver, kidney, or lung function and complete blood cell counts, may be performed while you use morphine solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use morphine solution with caution in the ELDERLY; they may be more sensitive to its effects, especially severe drowsiness, or slow or shallow breathing.
  • Morphine solution should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using morphine solution while you are pregnant. Morphine solution is found in breast milk. Do not breast-feed while taking morphine solution.

When used for long periods of time or at high doses, morphine solution may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if morphine solution stops working well. Do not take more than prescribed.

Some people who use morphine solution for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking morphine solution suddenly, you may have WITHDRAWAL symptoms. These may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of morphine solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; headache; lightheadedness; nausea; restless mood; sweating; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); confusion; disorientation; fainting; fast, slow, or irregular heartbeat; hallucinations; mental or mood changes (eg, agitation, exaggerated sense of well-being); seizures; severe or persistent constipation or stomach pain; severe or persistent dizziness, drowsiness, or headache; shortness of breath; slow or shallow breathing; sudden chest pain; swelling of the hands, ankles, or feet; trouble urinating; unusual bruising or bleeding; unusual tiredness or weakness; vision problems (eg, blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish skin or nails; cold and clammy skin; coma; confusion; decreased muscle tone; decreased pupil size; loss of consciousness; low body temperature; seizures; severe drowsiness, dizziness, or lightheadedness; severe muscle pain or weakness; shortness of breath; slow heartbeat; slow or shallow breathing.

Proper storage of morphine solution:

Store morphine solution between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep morphine solution out of the reach of children and away from pets.

General information:

  • If you have any questions about morphine solution, please talk with your doctor, pharmacist, or other health care provider.
  • Morphine solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take morphine solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about morphine solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to morphine solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using morphine solution.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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