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Metvixia cream

Generic Name: methyl aminolevulinate (METH-il a-MEE-noe-LEV-ue-LIN-ate)
Brand Name: Metvixia

Metvixia cream is used for:

Treating certain skin lesions (actinic keratoses) on the face or scalp. It is used along with red light treatment.

Metvixia cream is a photosensitizing agent. It works by slowing the growth of skin cells in the areas exposed to red light, which helps the skin to become less scaly and thick.

Do NOT use Metvixia cream if:

  • you are allergic to any ingredient in Metvixia cream; peanuts, peanut oil, or almond oil
  • you are allergic to porphyrins
  • you have a history of sensitivity to sunlight

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Metvixia cream:

Some medical conditions may interact with Metvixia cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a blood clotting problem, the blood disorder porphyria, or an immune system problem (eg, HIV)
  • if you have or have had skin cancer or other growths on your body

Some MEDICINES MAY INTERACT with Metvixia cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Medicines that may increase photosensitivity, such as griseofulvin, phenothiazines (eg, chlorpromazine), sulfonamides (eg, sulfamethoxazole), sulfonylureas (eg, glyburide), tetracyclines (eg, doxycycline), or thiazide diuretics (eg, hydrochlorothiazide). Ask your doctor if you are unsure if any of your medicines may increase this risk

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metvixia cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Metvixia cream:

Use Metvixia cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Metvixia cream. Talk to your doctor if you have questions about this information.
  • Metvixia cream will be applied at your doctor's office. Metvixia cream is used during two treatment sessions 1 week apart. Each treatment session is a two-part procedure. During each treatment session, Metvixia cream will be applied and you will receive a red light treatment on the same day.
  • Once Metvixia cream is applied, a special bandage will be placed over the treated area. Avoid exposure of treated areas to sunlight, bright indoor light, or extreme cold. After you have received Metvixia cream, your health care provider will give you the red light treatment. This is the second and final treatment step.
  • Before receiving the red light treatment, Metvixia cream will be rinsed off of your skin with water and you will be given goggles to protect your eyes. Do not stare into the light. The red light will not heat your skin.
  • During the red light treatment, you will experience pain, tingling, stinging, prickling, or burning of the treated area. The red light treatment can be stopped and restarted if needed. These effects stop at the end of treatment, which lasts for about 7 to 10 minutes.
  • After the red light treatment, keep the treated area covered and away from light for 48 hours.
  • If for any reason you cannot have the red light treatment after Metvixia cream is applied, rinse the cream off your skin and protect it from light. Continue to avoid bright light for at least 2 days.
  • If you miss a dose of Metvixia cream, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Metvixia cream.

Important safety information:

  • The treated area will be sensitive to light. Avoid exposing the treated area to sunlight and bright indoor light (eg, lamps, tanning beds, nearby lights) during the treatment period before the red light treatment and at least 48 hours after the red light treatment. Stinging, burning, flushing, and swelling may occur if the lesions are exposed to bright light.
  • Wear a wide-brimmed hat or similar head-covering of light, opaque material when exposed to sunlight or sources of bright light.
  • Sunscreens will not protect you from light sensitivity reactions. Do not use sunscreens on the treated lesions.
  • Do not apply any other medicine, creams, or lotions to the treated lesions unless instructed otherwise by your doctor.
  • Metvixia cream is for topical application to actinic keratoses on the face or scalp only. Avoid getting Metvixia cream in your eyes, on skin near your eyes, or on the mucous membranes of the mouth or nose.
  • Metvixia cream may be harmful if swallowed. If you or someone you know may have taken Metvixia cream by mouth, contact your local poison control center or emergency room immediately.
  • Burning, redness, stinging, and swelling of the treated skin should be gone in 3 weeks. If treated skin lesions get worse or if they do not completely resolve after 3 weeks, check with your doctor.
  • Use Metvixia cream with caution in the ELDERLY; they may be more sensitive to its effects.
  • Metvixia cream should be used with extreme caution in CHILDREN younger than 18 years of age; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Metvixia cream while you are pregnant. It is not known if Metvixia cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Metvixia cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Metvixia cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning; crusting; flushing; itching; pain; redness; scabbing; scaling; skin blisters; stinging; swelling; tenderness; tightness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding; change of skin color; oozing; pustules; severe or persistent burning, inflammation, irritation, pain, redness, or tenderness; swelling of the eyes or eyelids; ulceration; vision problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Metvixia cream may be harmful if swallowed.

Proper storage of Metvixia cream:

Metvixia cream is usually handled and stored by a health care provider. Keep Metvixia cream out of the reach of children and away from pets.

General information:

  • If you have any questions about Metvixia cream, please talk with your doctor, pharmacist, or other health care provider.
  • Metvixia cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Metvixia cream or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Metvixia cream. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Metvixia cream. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Metvixia cream.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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