Metoclopramide syrup

Pronunciation

Generic Name: metoclopramide (meht-oh-KLOE-pra-mide)
Brand Name: Generic only. No brands available.

Metoclopramide syrup is used for:

Short term treatment of gastroesophageal reflux disease (GERD) in certain patients who do not respond to other therapy. It is used to treat symptoms of a certain digestive problem in diabetic patients (diabetic gastroparesis). It may also be used for other conditions as determined by your doctor.

Metoclopramide syrup is a gastrointestinal stimulant and anti-nauseant. It works by increasing the movement of the stomach and intestines to help move food and acid out of the stomach more quickly. It also works in certain areas in the brain to decrease nausea.

Do NOT use metoclopramide syrup if:

  • you are allergic to any ingredient in metoclopramide syrup
  • you have seizures (eg, epilepsy); bleeding, blockage, or perforation in your stomach or intestines; or tumors on your adrenal gland (pheochromocytoma)
  • you are taking cabergoline or pergolide
  • you are taking medicines, such as phenothiazines (eg, chlorpromazine), that may cause extrapyramidal reactions (abnormal, involuntary muscle movements of the head, neck, or limbs)

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update - First Time Brand-to-Generic Switches

Before using metoclopramide syrup:

Some medical conditions may interact with metoclopramide syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have depression, asthma, heart failure, high blood pressure, diabetes, Parkinson disease, blood problems (eg, porphyria), kidney problems, or low levels of an enzyme called methemoglobin reductase

Some MEDICINES MAY INTERACT with metoclopramide syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cisapride or droperidol because side effects, such as muscle rigidity, increased heart rate, and altered mental abilities, may occur
  • Anticholinergic medicine (eg, hyoscyamine), certain antihistamines (eg, diphenhydramine), or narcotic pain medicines (eg, codeine) because they may decrease metoclopramide syrup's effectiveness
  • Acetaminophen, alcohol, levodopa, phenothiazines (eg, chlorpromazine), sedatives (eg, zolpidem), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), succinylcholine, or tetracycline because the risk of their side effects may be increased by metoclopramide syrup
  • Monoamine oxidase inhibitors (eg, phenelzine) because the risk of serious side effects (eg, high blood pressure, seizures) may be increased
  • Cabergoline, digoxin, or pergolide because their effectiveness may be decreased by metoclopramide syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if metoclopramide syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use metoclopramide syrup:

Use metoclopramide syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take metoclopramide syrup by mouth 30 minutes before meals unless directed otherwise by your doctor.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • It may take several days to weeks for metoclopramide syrup to work. Do not stop using metoclopramide syrup without checking with your doctor.
  • If you miss a dose of metoclopramide syrup, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use metoclopramide syrup.

Important safety information:

  • Metoclopramide syrup may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use metoclopramide syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using metoclopramide syrup without first checking with your doctor; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Diabetes patients- Metoclopramide syrup may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by metoclopramide syrup. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Some patients who take metoclopramide syrup may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take metoclopramide syrup in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking metoclopramide syrup.
  • Lab tests, including liver and kidney function tests, may be performed while you use metoclopramide syrup. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Metoclopramide syrup should not be used in CHILDREN younger than 15 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using metoclopramide syrup while you are pregnant. Metoclopramide syrup is found in breast milk. If you are or will be breast-feeding while you use metoclopramide syrup, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of metoclopramide syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Decreased energy; diarrhea; dizziness; drowsiness; headache; nausea; restlessness; tiredness; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thinking; confusion; dark urine; decreased coordination; decreased sexual ability; fast, slow, or irregular heartbeat; fever; hallucinations; loss of bladder control; mental or mood changes (eg, depression, anxiety, agitation, jitteriness); seizures; severe or persistent dizziness, headache, or trouble sleeping; severe or persistent restlessness, including inability to sit still; shortness of breath; stiff or rigid muscles; sudden increased sweating; sudden unusual weight gain; suicidal thoughts or actions; swelling of the arms, legs, or feet; uncontrolled muscle movements (eg, of the arms, legs, tongue, jaw, cheeks; twitching; tremors); vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; confusion; drowsiness; muscle restlessness; unusual movement of eyes, face, or limbs.

Proper storage of metoclopramide syrup:

Store metoclopramide syrup at room temperature, between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep metoclopramide syrup out of the reach of children and away from pets.

General information:

  • If you have any questions about metoclopramide syrup, please talk with your doctor, pharmacist, or other health care provider.
  • Metoclopramide syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about metoclopramide syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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