Mesna

Generic Name: mesna (MES-na)
Brand Name: Mesnex

Mesna is used for:

Preventing or reducing the harmful effects of chemotherapy on the bladder.

Mesna is a detoxifying agent. It works by protecting the bladder wall from the harmful effects of chemotherapy.

Do NOT use mesna if:

  • you are allergic to any ingredient in mesna

Contact your doctor or health care provider right away if any of these apply to you.

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Before using mesna:

Some medical conditions may interact with mesna. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with mesna. However, no specific interactions with mesna are known at this time.

Ask your health care provider if mesna may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use mesna:

Use mesna as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with mesna. Talk to your pharmacist if you have questions about this information.
  • Mesna is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • Be sure to drink enough fluids while taking mesna. Drink 4 to 8 cups (1 to 2 liters) of liquid per day unless your doctor has told you otherwise.
  • If you miss a dose of mesna, contact your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use mesna.

Important safety information:

  • Tell your doctor if your urine turns a pink or red color.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • Diabetes patients - Mesna may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Mesna may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking mesna.
  • Lab tests, including urine tests, may be performed while you use mesna. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Mesna has benzyl alcohol in it. Do not use it in NEWBORNS or INFANTS. It may cause serious and sometimes fatal side effects. If you have questions, check with your doctor or pharmacist.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using mesna while you are pregnant. It is unknown if mesna is found in breast milk. Do not breast-feed while taking mesna.

Possible side effects of mesna:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; hair loss; headache; injection-site reaction; loss of appetite; nausea; stomach pain; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, face, lips, hands, eyes, throat, or tongue); blood in the urine (pink or red urine); burning feeling; change in the amount of urine produced; chest pain; fainting; fast heartbeat; fever, chills, cough, or sore throat; flu-like symptoms; flushing; muscle or joint pain; severe or persistent dizziness, nausea, or vomiting; shortness of breath; unusual bruising or bleeding; unusual tiredness of weakness; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of mesna:

Mesna is handled and stored by a health care provider. Keep mesna out of the reach of children and away from pets.

General information:

  • If you have any questions about mesna, please talk with your doctor, pharmacist, or other health care provider.
  • Mesna is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take mesna or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about mesna. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to mesna. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using mesna.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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