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Meloxicam

Pronunciation

Generic Name: meloxicam (mel-OX-i-kam)
Brand Name: Mobic

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take meloxicam for a long time. Do not use meloxicam right before or after bypass heart surgery.

Meloxicam may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.


Meloxicam is used for:

Treating rheumatoid arthritis, osteoarthritis, and juvenile arthritis. It may also be used for other conditions as determined by your doctor.

Meloxicam is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use meloxicam if:

  • you are allergic to any ingredient in meloxicam
  • you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)
  • you have recently had or will be having bypass heart surgery
  • you have a peptic ulcer
  • you are in the last 3 months of pregnancy
  • you are having problems becoming pregnant or you are having your fertility checked

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment Options for Rheumatoid Arthritis

Doctor Ariel D. Teitel discusses several treatments that can help control the progression of the disease and help to alleviate the swelling and pain.

Before using meloxicam:

Some medical conditions may interact with meloxicam. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney or liver disease, diabetes, stomach or bowel problems (eg, bleeding, perforation, ulcers), or Helicobacter pylori infection
  • if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation
  • if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
  • if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol or smoke, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with meloxicam. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), antiplatelet medicines (eg, clopidogrel), apixaban, aspirin, bisphosphonates (eg, alendronate), corticosteroids (eg, prednisone), dabigatran, desirudin, heparin, rivaroxaban, or serotonin reuptake inhibitors (eg, fluoxetine) because the risk of stomach bleeding may be increased
  • Probenecid because it may increase the risk of meloxicam's side effects
  • Cholestyramine because it may decrease meloxicam's effectiveness
  • Cyclosporine, lithium, methotrexate, pemetrexed, quinolones (eg, ciprofloxacin), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by meloxicam
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin receptor blockers (eg, losartan), or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by meloxicam, and the risk of kidney problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if meloxicam may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use meloxicam:

Use meloxicam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Meloxicam comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get meloxicam refilled.
  • Take meloxicam by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
  • Take meloxicam with a full glass of water (8 oz/240 mL) as directed by your doctor.
  • If you take cholestyramine, ask your doctor or pharmacist how to take it with meloxicam.
  • If you miss a dose of meloxicam, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use meloxicam.

Important safety information:

  • Meloxicam may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use meloxicam with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Serious stomach ulcers or bleeding can occur with the use of meloxicam. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking meloxicam with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Meloxicam is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do not take aspirin while you are using meloxicam unless your doctor tells you to.
  • NSAIDs, including meloxicam, may be associated with a reversible delay in ovulation in women. This may affect the ability to become pregnant. Discuss any questions or concerns with your doctor.
  • Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be performed while you use meloxicam. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use meloxicam with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.
  • Caution is advised when using meloxicam in CHILDREN; they may be more sensitive to its effects, especially diarrhea, fever, headache, stomach pain, and vomiting.
  • Meloxicam should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been determined.
  • PREGNANCY and BREAST-FEEDING: Meloxicam may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using meloxicam while you are pregnant. It is not known if meloxicam is found in breast milk. Do not breast-feed while taking meloxicam.

Possible side effects of meloxicam:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; mild stomach pain; nausea; stomach upset; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; difficult or painful urination; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; loss of appetite; mental or mood changes (eg, depression); numbness of an arm or leg; one-sided weakness; pale stools; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe or persistent headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; decreased urination; loss of consciousness; seizures; severe dizziness, headache, or drowsiness; severe nausea, vomiting, or stomach pain; slow or troubled breathing; sluggishness; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, severe stomach pain, yellowing of the skin or eyes); symptoms of stomach or bowel bleeding (eg, bloody or black, tarry stools; vomit that looks like coffee grounds).

Proper storage of meloxicam:

Store meloxicam at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep meloxicam out of the reach of children and away from pets.

General information:

  • If you have any questions about meloxicam, please talk with your doctor, pharmacist, or other health care provider.
  • Meloxicam is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take meloxicam or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about meloxicam. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to meloxicam. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using meloxicam.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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