Mechlorethamine gel

Generic Name: mechlorethamine (MEK-lor-ETH-a-meen)
Brand Name: Valchlor

Mechlorethamine gel is used for:

Treating certain types of skin cancer.

Do NOT use mechlorethamine gel if:

  • you are allergic to any ingredient in mechlorethamine gel

Contact your doctor or health care provider right away if any of these apply to you.

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Before using mechlorethamine gel:

Some medical conditions may interact with mechlorethamine gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with mechlorethamine gel. Because little, if any, of mechlorethamine gel is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if mechlorethamine gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use mechlorethamine gel:

Use mechlorethamine gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Mechlorethamine gel comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get mechlorethamine gel refilled.
  • Apply mechlorethamine gel right away or within 30 minutes after you take it out of the refrigerator.
  • Put the tube back in the original box and return it to the refrigerator immediately after each use.
  • Apply a thin film of mechlorethamine gel to dry skin at least 4 hours before or 30 minutes after showering or washing. Allow mechlorethamine gel to dry for 5 to 10 minutes before covering with clothing.
  • Wash your hands immediately after using mechlorethamine gel, unless your hands are part of the treated area.
  • Do not bandage or cover the treated area, unless directed to do so by your doctor.
  • Caregivers must wear special gloves when applying mechlorethamine gel. Do not let anyone come into contact with the treated area. If contact occurs, wash the affected areas of the skin with soap and water for at least 15 minutes and remove any contaminated clothing.
  • If you miss a dose of mechlorethamine gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use mechlorethamine gel.

Important safety information:

  • Mechlorethamine gel may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
  • Mechlorethamine gel is for external use only. Do not get it in your eyes, nose, mouth, or other mucus membranes. If you get it in any of these areas, rinse at once with cool water for at least 15 minutes. If you get mechlorethamine gel in your eyes, it may cause severe problems including blindness. Contact your doctor immediately.
  • Mechlorethamine gel is flammable. Avoid fire, flame, and smoking until it has dried.
  • Do not use other medicines or products on the treated area without first checking with your doctor. Moisturizers may be applied to the treated areas 2 hours before or 2 hours after applying mechlorethamine gel.
  • Mechlorethamine gel may increase the risk of certain types of skin cancers. Your doctor will check your skin during and after you stop using mechlorethamine gel. Tell your doctor if you get any new skin lesions.
  • Use mechlorethamine gel with caution in the ELDERLY; they may be more sensitive to its effects.
  • Mechlorethamine gel should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Mechlorethamine gel may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using mechlorethamine gel while you are pregnant. It is not known if mechlorethamine gel is found in breast milk after topical use. Do not breast-feed while you are using mechlorethamine gel.

Possible side effects of mechlorethamine gel:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in skin color; mild redness, swelling, or itching at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in size or appearance of a mole; fever; skin blisters or ulcers; unusual skin growths or lumps; warm, red, swollen, or painful skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of mechlorethamine gel:

Store mechlorethamine gel in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Check with your pharmacist if mechlorethamine gel is left at room temperature for more than 1 hour a day. Throw away any unused medicine after 60 days. Keep mechlorethamine gel out of the reach of children and away from pets.

General information:

  • If you have any questions about mechlorethamine gel, please talk with your doctor, pharmacist, or other health care provider.
  • Mechlorethamine gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take mechlorethamine gel or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about mechlorethamine gel. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to mechlorethamine gel. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using mechlorethamine gel.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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