Generic Name: nitrofurantoin (NYE-troe-fure-AN-toin)
Brand Name: Macrobid
Macrobid is used for:
Treating and preventing urinary tract infections caused by certain bacteria.
Macrobid is an antibiotic for specific use in the urinary tract. It works by killing sensitive bacteria.
Do NOT use Macrobid if:
- you are allergic to any ingredient in Macrobid
- you are pregnant and at term (38 to 42 weeks pregnant), you are about to go into labor, or you are in labor
- you have decreased kidney function or decreased urination, or if you are unable to urinate
- you have a history of liver problems or yellowing of the skin or eyes after taking any form of Macrobid
- the patient is younger than 1 month old
Contact your doctor or health care provider right away if any of these apply to you.
Before using Macrobid:
Some medical conditions may interact with Macrobid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have anemia, diabetes, blood electrolyte problems, glucose-6-phosphate dehydrogenase (G6PD) deficiency, kidney problems, liver problems, nerve problems (eg, peripheral neuropathy), porphyria (a certain blood problem), or low levels of vitamin B in your blood
- if you have a history of lung problems (eg, diffuse interstitial pneumonitis, pulmonary fibrosis)
- if you have very poor health
Some MEDICINES MAY INTERACT with Macrobid. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Probenecid or sulfinpyrazone because they may increase the risk of Macrobid's side effects or decrease Macrobid's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if Macrobid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Macrobid:
Use Macrobid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Macrobid by mouth with food.
- Drinking extra fluids while you are taking Macrobid is recommended. Check with your doctor for instructions.
- Do not take an antacid that has magnesium trisilicate in it while you are taking Macrobid. Check with your pharmacist if you are unsure which antacids have magnesium trisilicate in them.
- To clear up your infection completely, take Macrobid for the full course of treatment. Keep taking it even if you feel better in a few days.
- If you miss a dose of Macrobid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Macrobid.
Important safety information:
- Macrobid may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Macrobid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Macrobid may rarely cause severe and sometimes fatal lung problems. If this occurs, it is usually in patients who take Macrobid for 6 months or longer. These problems may occur without warning signs. If you will be using Macrobid for a long period of time, your doctor may perform lung function tests to check for side effects. Tell your doctor right away if you develop fever, chills, chest pain, unusual cough, trouble breathing (especially while you are being active), other breathing problems, or persistent feeling of being unwell.
- Macrobid may rarely cause severe and sometimes fatal liver problems. Tell your doctor right away if you develop yellowing of the skin or eyes; pale stools; or severe or persistent nausea, loss of appetite, or stomach pain.
- Macrobid may rarely cause severe and sometimes fatal nerve problems. The risk may be greater in patients who have decreased kidney function, anemia, diabetes, electrolyte problems, or low blood vitamin B levels. Tell your doctor right away if you develop numbness, burning, or tingling in the hands or feet.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Long-term or repeated use of Macrobid may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Macrobid only works against bacteria; it does not treat viral infections (eg, the common cold).
- Be sure to use Macrobid for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Macrobid may discolor the urine. This is normal and not a cause for concern.
- Diabetes patients - Macrobid may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
- Lab tests, including liver function, kidney function, and lung function, may be performed while you use Macrobid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Macrobid with caution in the ELDERLY; they may be more sensitive to its effects, especially lung or liver problems.
- Macrobid should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
- Macrobid should not be used in CHILDREN younger than 1 month old; the risk of anemia may be greater in these children.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Macrobid while you are pregnant. Do NOT take Macrobid if you are at term (38 to 42 weeks pregnant), if you are about to go into labor, or if you are in labor. Macrobid is found in breast milk. Do not breast-feed infants younger than 1 month old while you are taking Macrobid. If your child is older than 1 month, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Macrobid:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Gas; headache; loss of appetite; mild diarrhea; nausea.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or watery stools; bluish skin or nails; blurred vision or other vision changes (eg, vision loss); butterfly-shaped rash on the nose and cheeks; confusion; eye pain; joint or muscle pain; mood or mental changes (eg, depression); persistent feeling of being unwell; red, swollen, blistered, or peeling skin; severe or persistent diarrhea; severe or persistent headache; severe stomach pain or cramps; symptoms of liver problems (eg, yellowing of the eyes or skin, dark urine, pale stools, severe or persistent nausea or loss of appetite, stomach pain); symptoms of lung problems (eg, fever, chills, chest pain, shortness of breath, unusual or persistent cough); tingling, numbness, or burning of the hands or feet; unusual bruising or bleeding; unusual tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include vomiting.Proper storage of Macrobid:
Store Macrobid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Macrobid out of the reach of children and away from pets.
- If you have any questions about Macrobid, please talk with your doctor, pharmacist, or other health care provider.
- Macrobid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Macrobid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Macrobid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Macrobid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Macrobid.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More Macrobid resources
- Macrobid Prescribing Information (FDA)
- Macrobid Consumer Overview
- Nitrofurantoin Professional Patient Advice (Wolters Kluwer)
- Nitrofurantoin Monograph (AHFS DI)
- Furadantin Advanced Consumer (Micromedex) - Includes Dosage Information
- Furadantin Prescribing Information (FDA)
- Macrodantin Prescribing Information (FDA)