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Lysodren

Generic Name: mitotane (MYE-toe-tane)
Brand Name: Lysodren

Lysodren may reduce the amount of natural steroid in the body. This may decrease your ability to recover from physical stress such as illness, injury, or surgery. Tell your doctor or dentist that you take Lysodren before you receive any medical or dental care, emergency care, or surgery. Tell your doctor right away if you become ill or have an injury while you use Lysodren. You may need to stop taking Lysodren for a period of time. You may need to take a corticosteroid (eg, prednisone) until your body can make enough on its own. Check with your doctor for more information.


Lysodren is used for:

Treating adrenal cortical cancer that cannot be treated with surgery.

Lysodren is an adrenal cytotoxic agent. Exactly how Lysodren works is not known. It may work by slowing adrenal gland function.

Do NOT use Lysodren if:

  • you are allergic to any ingredient in Lysodren
  • you have suffered severe trauma or shock

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Lysodren:

Some medical conditions may interact with Lysodren. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems
  • if you will be having surgery

Some MEDICINES MAY INTERACT with Lysodren. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin) because their effectiveness may be decreased by Lysodren

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lysodren may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lysodren:

Use Lysodren as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Lysodren by mouth with or without food.
  • Lysodren may be started in a hospital setting until an individualized dose is determined.
  • If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
  • Swallow Lysodren whole. Do not break, crush, or chew before swallowing.
  • To minimize the risk of skin exposure always wear gloves when handling bottles containing Lysodren.
  • Be sure you know how to properly handle and dispose of Lysodren. Ask your doctor or pharmacist if you are unsure.
  • If you miss a dose of Lysodren, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lysodren.

Important safety information:

  • Lysodren may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Lysodren with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Tell your doctor or dentist that you take Lysodren before you receive any medical or dental care, emergency care, or surgery.
  • If you may become pregnant, you must use an effective form of birth control while you take Lysodren and for a period of time after stopping it. If you have questions about effective birth control, talk with your doctor.
  • Lab tests, such as adrenal function tests and neurological and behavioral tests, may be performed while you use Lysodren. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Lysodren should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Lysodren may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lysodren while you are pregnant. Lysodren is found in breast milk. Do not breast-feed while taking Lysodren.

Possible side effects of Lysodren:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; lack of energy; loss of appetite; nausea; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; blurred vision, double vision, or other vision changes; confusion; depression; fainting; fever, chills, or persistent sore throat; severe or persistent dizziness, drowsiness, headache, light-headedness, or tiredness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Lysodren:

Store Lysodren at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lysodren out of the reach of children and away from pets.

General information:

  • If you have any questions about Lysodren, please talk with your doctor, pharmacist, or other health care provider.
  • Lysodren is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Lysodren or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Lysodren. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Lysodren. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Lysodren.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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