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Generic Name: indapamide (in-DAP-a-mide)
Brand Name: Lozol

Lozol is used for:

Treating high blood pressure alone or along with other medicines. It is also used to treat salt and water retention (swelling) associated with congestive heart failure.

Lozol is a diuretic. It works by causing the kidneys to eliminate large amounts of water and salts.

Do NOT use Lozol if:

  • you are allergic to any ingredient in Lozol or to a sulfonamide medicine (eg, sulfamethoxazole)
  • you are unable to urinate
  • you are taking ketanserin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lozol:

Some medical conditions may interact with Lozol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems (eg, irregular heartbeat, heart failure), liver problems (eg, cirrhosis), kidney disease, gout, lupus, problems urinating, or swelling
  • if you have severe or persistent vomiting, or low blood levels of sodium or potassium, or if you are on a low-salt (sodium) diet
  • if you have had a certain neurosurgical procedure (sympathectomy)
  • if you are receiving fluids through a vein (parenteral fluids)

Some MEDICINES MAY INTERACT with Lozol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because they may decrease Lozol's effectiveness
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of kidney problems may be increased
  • Diazoxide because the risk of high blood glucose levels, high uric acid levels, or low blood pressure may be increased
  • Adrenocorticotropin hormone (ACTH) or corticosteroids (eg, prednisone) because they may increase the risk of Lozol's side effects
  • Amantadine, antineoplastic agents (eg, cyclophosphamide), digitalis glycosides (eg, digoxin), ketanserin, lithium, or other blood pressure medicines because the risk of their side effects may be increased by Lozol

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lozol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lozol:

Use Lozol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Lozol by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Lozol may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Lozol and you are taking 1 dose daily, take the missed dose if you remember the same day. Skip the missed dose if you do not remember until the next day. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lozol.

Important safety information:

  • Lozol may cause drowsiness, dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Lozol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Lozol may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Your doctor may check your blood electrolytes while you take Lozol to check for a fluid or electrolyte imbalance. Tell your doctor right away if you experience decreased urination; dry mouth; fainting; fast or irregular heartbeat; increased thirst; muscle pain, weakness, or cramping; restlessness; severe dizziness or drowsiness; stomach problems; or unusual tiredness or weakness.
  • Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
  • Lozol may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Lozol. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Lozol before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Lozol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lozol may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Lozol.
  • Lab tests, including blood electrolyte, glucose, and uric acid levels, and kidney function, may be performed while you use Lozol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Lozol with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood sodium or potassium.
  • Lozol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lozol while you are pregnant. It is not known if Lozol is found in breast milk. Do not breast-feed while taking Lozol.

Possible side effects of Lozol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; constipation; diarrhea; dizziness or lightheadedness when siting up or standing; drowsiness; headache; nausea; nervousness; runny nose; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; dark urine; decreased urination or urination problems; dry mouth; fainting; fast heartbeat; fatigue; fever, chills, cough, or sore throat; increased thirst; loss of appetite; numbness of the hands or feet; pale stools; red, swollen, blistered, or peeling skin; severe or persistent dizziness, drowsiness, or lightheadedness; severe stomach pain; swelling of the hands, ankles, or feet; symptoms of low blood potassium (eg, irregular heartbeat; muscle pain, weakness, or cramping); symptoms of low blood sodium (eg, confusion, mental or mood changes, seizures, sluggishness); unusual bruising or bleeding; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include nausea; vomiting; weakness.

Proper storage of Lozol:

Store Lozol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lozol out of the reach of children and away from pets.

General information:

  • If you have any questions about Lozol, please talk with your doctor, pharmacist, or other health care provider.
  • Lozol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Lozol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Lozol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Lozol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Lozol.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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