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Lorcaserin

Generic Name: lorcaserin (lor-KA-ser-in)
Brand Name: Belviq

Lorcaserin is used for:

Chronic weight management in certain patients. It is used along with a reduced-calorie diet and increased physical activity.

Lorcaserin is a serotonin 2C receptor agonist. The exact way lorcaserin works is not known. It is thought to work in the brain to promote a full feeling and decrease hunger.

Do NOT use lorcaserin if:

  • you are allergic to any ingredient in lorcaserin
  • you are pregnant or are planning to become pregnant
  • you have severe kidney problems
  • you are taking cabergoline

Contact your doctor or health care provider right away if any of these apply to you.

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Before using lorcaserin:

Some medical conditions may interact with lorcaserin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a deformed penis (eg, cavernosal fibrosis, Peyronie disease), blood cell problems (eg, leukemia, multiple myeloma, sickle cell anemia), or a history of a prolonged (more than 4 hours) or painful erection (priapism)
  • if you have high blood prolactin levels
  • if you have a history of diabetes, heart problems (eg, heart failure, heart valve problems, slow or irregular heartbeat), kidney problems, liver problems, or high blood pressure in the lungs (pulmonary hypertension)
  • if you have a history of mental or mood problems (eg, depression) or suicidal thoughts or actions
  • if you are taking any other medicine for weight loss (eg, phentermine)
  • if you are taking insulin or another medicine for diabetes

Some MEDICINES MAY INTERACT with lorcaserin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antipsychotics (eg, risperidone), bupropion, dextromethorphan, linezolid, lithium, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, venlafaxine), St. John's wort, tramadol, tricyclic antidepressants (eg, amitriptyline), triptans (eg, sumatriptan), or tryptophan because the risk of certain severe side effects called serotonin syndrome and neuroleptic malignant syndrome (NMS) may be increased
  • Cabergoline because the risk of heart valve problems may be increased
  • Phosphodiesterase type 5 (PDE5) inhibitors (eg sildenafil) because the risk of priapism (prolonged or painful erection) may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if lorcaserin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use lorcaserin:

Use lorcaserin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with lorcaserin. Talk to your pharmacist if you have questions about this information.
  • Take lorcaserin by mouth with or without food.
  • If you miss a dose of lorcaserin, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use lorcaserin.

Important safety information:

  • Lorcaserin may cause drowsiness, dizziness, or trouble concentrating or thinking. These effects may be worse if you take it with alcohol or certain medicines. Use lorcaserin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • Tell your doctor or dentist that you take lorcaserin before you receive any medical or dental care, emergency care, or surgery.
  • Follow the diet and exercise program given to you by your health care provider.
  • You should have your weight checked by your doctor by the 12th week of treatment with lorcaserin. Your doctor will determine if you should continue or stop taking lorcaserin.
  • Diabetes patients - Weight loss may increase the risk of low blood sugar in patients with type 2 diabetes treated with insulin or other diabetes medicines, such as sulfonylureas (eg, glipizide). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you hungrier. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Serotonin syndrome is a possibly fatal syndrome that can be caused by lorcaserin. Your risk may be greater if you take lorcaserin with certain other medicines (eg, "triptans," MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
  • NMS is a possibly fatal syndrome that can be caused by lorcaserin. Symptoms may include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact your doctor at once if you have any of these symptoms.
  • Lorcaserin may rarely cause a prolonged (more than 4 hours) or painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.
  • Lorcaserin may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Lorcaserin may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms.
  • Lab tests, including complete blood cell counts, may be performed while you use lorcaserin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Lorcaserin should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not take lorcaserin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if lorcaserin is found in breast milk. Do not breast-feed while taking lorcaserin.

Possible side effects of lorcaserin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; constipation; cough; dizziness; dry mouth; headache; nausea; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; decreased coordination; difficult or painful urination; fast, slow, or irregular heartbeat; fainting; fever, chills, or persistent sore throat; hallucinations; memory problems; new or worsening mental, mood, or behavior changes (eg, agitation, depression); muscle spasms or twitching; prolonged or painful erection; restlessness; severe or persistent headache or dizziness; shortness of breath or trouble breathing; sudden, unexplained weight gain; suicidal thoughts or actions; swelling of the hands, ankles, legs, or feet; trouble concentrating or thinking; unusual tiredness or weakness; vision changes (eg, blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include hallucinations; mental or mood changes (eg, feeling high or out of your body); severe or persistent dizziness, headache, nausea, or stomach discomfort.

Proper storage of lorcaserin:

Store lorcaserin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep lorcaserin out of the reach of children and away from pets.

General information:

  • If you have any questions about lorcaserin, please talk with your doctor, pharmacist, or other health care provider.
  • Lorcaserin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take lorcaserin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about lorcaserin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to lorcaserin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using lorcaserin.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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