Lorazepam solution

Pronunciation

Generic Name: lorazepam (lor-AZ-e-pam)
Brand Name: Ativan

Lorazepam solution is used for:

Treating anxiety and causing drowsiness before certain medical procedures and treating certain types of seizures. It may also be prescribed for other conditions as determined by your doctor.

Lorazepam solution is a benzodiazepine. It works by slowing down the movement of chemicals in the brain. This results in a reduction in nervous tension (anxiety) and causes sedation.

Do NOT use lorazepam solution if:

  • you are allergic to any ingredient in lorazepam solution or any other benzodiazepine (eg, alprazolam)
  • you have narrow-angle glaucoma, psychosis, sleep apnea, or severe liver disease
  • you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using lorazepam solution:

Some medical conditions may interact with lorazepam solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are taking any other medicine that causes drowsiness (eg, narcotics, some antidepressants)
  • if you have lung function problems, chronic obstructive pulmonary disease (COPD), muscle weakness or fatigue, glaucoma, liver or kidney problems, a blood disorder, depression, or suicidal thoughts
  • if you have a history of alcohol or substance abuse or dependence

Some MEDICINES MAY INTERACT with lorazepam solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or theophyllines because they may decrease lorazepam solution's effectiveness
  • Clozapine, haloperidol, kava, loxapine, narcotic pain relievers (eg, morphine, codeine), sodium oxybate (GHB), or valproic acid because side effects, such as extreme sedation, slowed breathing, confusion, or memory problems, may occur
  • Digoxin, hydantoins (eg, phenytoin), narcotic pain relievers (eg, morphine, codeine), nondepolarizing muscle relaxants (eg, vecuronium), or sodium oxybate (GHB) because the risk of their side effects may be increased by lorazepam solution
  • Nondepolarizing muscle relaxants (eg, vecuronium) because they may decrease lorazepam solution's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if lorazepam solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use lorazepam solution:

Use lorazepam solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Lorazepam solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using lorazepam solution at home, a health care provider will teach you how to use it. Be sure you understand how to use lorazepam solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use lorazepam solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Lorazepam solution should not be injected into an artery because serious side effects may occur.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of lorazepam solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use lorazepam solution.

Important safety information:

  • Lorazepam solution may cause drowsiness, dizziness, and blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use lorazepam solution with caution. Do not drive or perform other possibly unsafe tasks for up to 48 hours after use.
  • Do not drink alcohol for at least 24 to 48 hours after using lorazepam solution. Do not use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using lorazepam solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Effects, such as drowsiness, relief of anxiety, and lack of remembering and recognizing events the day of surgery, will last about 8 hours.
  • Other types of sedatives, tranquilizers, and narcotic pain relievers may cause a longer and more intense effect when taken with lorazepam solution. Excessive sleepiness, drowsiness, and memory problems (eg, difficulty remembering and recognizing events the day of and the day after surgery) may occur.
  • Do not attempt to get out of bed without help. Trying to get out of bed within 8 hours of receiving lorazepam solution may result in falling or injury.
  • Use lorazepam solution with caution in the ELDERLY; they may be more sensitive to its effects.
  • Lorazepam solution should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Lorazepam solution has been shown to cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using lorazepam solution while you are pregnant. Lorazepam solution is found in breast milk. Do not breast-feed while taking lorazepam solution.

Some people who use lorazepam solution for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you stop taking lorazepam solution suddenly, you may have WITHDRAWAL symptoms. These may include agitation, anxiety, irritability, occasional seizures, or sleeplessness may occur if lorazepam solution is suddenly stopped. If you need to stop lorazepam solution, your doctor will lower your dose over time.

Possible side effects of lorazepam solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; dry mouth; excessive sleepiness and drowsiness; headache; pain, swelling, or redness at the injection area; short-term memory loss; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms of overdose may include clumsiness; confusion; deep sleep; loss of consciousness; slow reflexes.

Proper storage of lorazepam solution:

Store lorazepam solution in a refrigerator at 36 to 46 degrees F (2 to 8 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Store in original packaging until just before use. Keep lorazepam solution out of the reach of children and away from pets.

General information:

  • If you have any questions about lorazepam solution, please talk with your doctor, pharmacist, or other health care provider.
  • Lorazepam solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take lorazepam solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about lorazepam solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to lorazepam solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using lorazepam solution.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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