Lithostat

Generic Name: acetohydroxamic acid (ass-EE-toe-high-drox-AM-ic)
Brand Name: Lithostat

Lithostat is used for:

Treating certain types of chronic urinary infections (urea-splitting) in combination with surgery (for patients with stones) or antibiotic medicines. It may also be used for other conditions as determined by your doctor.

Lithostat is a urease inhibitor. It works by decreasing ammonia levels and pH in the urine. This helps antibiotics to work better and decreases kidney stone formation.

Do NOT use Lithostat if:

  • you are allergic to any ingredient in Lithostat
  • you have a urinary infection that can be controlled by other medications or surgery
  • your urine is infected by bacteria that do not respond to Lithostat
  • you have severe kidney problems
  • you are pregnant, or you are able to become pregnant and are not using an appropriate form of birth control

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Lithostat:

Some medical conditions may interact with Lithostat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney problems, bone marrow problems, blood vessel problems, or a history of blood clots

Some MEDICINES MAY INTERACT with Lithostat. However, no specific interactions with Lithostat are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lithostat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lithostat:

Use Lithostat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Lithostat on an empty stomach at least 1 hour before or 2 hours after eating.
  • Lithostat comes with an additional patient leaflet. Read it carefully and reread it each time you get Lithostat refilled.
  • Do not take iron supplements or vitamins containing iron while you are using Lithostat, unless otherwise directed by your doctor.
  • Continue to use Lithostat even if you feel well. Do not miss any doses.
  • If you miss a dose of Lithostat, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lithostat.

Important safety information:

  • Talk with your doctor before using alcohol while taking Lithostat. You may develop a rash and general sensation of warmth if you consume alcoholic beverages while taking Lithostat.
  • Women must use an effective form of birth control while taking Lithostat.
  • LAB TESTS, including liver function, kidney function, and blood counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Caution is advised when using Lithostat in CHILDREN because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: Do not use Lithostat if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. If you are able to become pregnant, talk with your doctor or pharmacist about the use of effective birth control while using Lithostat. It is unknown if Lithostat is excreted in breast milk. Do not breast-feed while taking Lithostat.

Possible side effects of Lithostat:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; general body discomfort; hair loss; loss of appetite; mild headaches; nausea; nervousness; shakiness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood vessel inflammation; calf pain, swelling, or tenderness; dark urine; depression; emotional or mood changes; irregular heartbeat; severe nausea, vomiting, or fatigue; unusual tiredness or weakness; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include anxiety; diminished sense of well-being; severe anxiety, nausea, or vomiting; sluggishness.

Proper storage of Lithostat:

Store Lithostat at room temperature, between 59 and 86 degrees F (15 and 30 degrees C) in a tightly sealed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lithostat out of the reach of children and away from pets.

General information:

  • If you have any questions about Lithostat, please talk with your doctor, pharmacist, or other health care provider.
  • Lithostat is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Lithostat or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Lithostat. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Lithostat. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Lithostat.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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