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Linezolid suspension

Pronunciation

Generic Name: linezolid (lin-AYZ-oh-lid)
Brand Name: Zyvox

Linezolid suspension is used for:

Treating certain bacterial infections.

Linezolid suspension is an oxazolidinone antibiotic. It works by interfering with the production of proteins needed by bacteria to grow.

Do NOT use linezolid suspension if:

  • you are allergic to any ingredient in linezolid suspension
  • you are taking an amphetamine (eg, dextroamphetamine), an anorexiant (eg, phentermine), a catechol-O-methyltransferase (COMT) inhibitor (eg, entacapone), cyclobenzaprine, dexmethylphenidate, fentanyl, levodopa, meperidine, sibutramine, a sympathomimetic (eg, pseudoephedrine), tetrabenazine, or a triptan (eg, sumatriptan)
  • you are taking or have taken apraclonidine, bupropion, buspirone, dextromethorphan, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine, selegiline), nefazodone, a norepinephrine reuptake inhibitor (eg, atomoxetine), a serotonin-norepinephrine reuptake inhibitor (SNRI) (eg, duloxetine, venlafaxine), a selective serotonin reuptake inhibitor (SSRI) (eg, paroxetine), a tetracyclic antidepressant (eg, maprotiline, mirtazapine), trazodone, a tricyclic antidepressant (eg, amitriptyline, doxepin), or vilazodone within the past 14 days
  • you are taking or have taken fluoxetine within the past 5 weeks

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update: First Time Brand-to-Generic Switches

Before using linezolid suspension:

Some medical conditions may interact with linezolid suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of diabetes, high blood pressure, kidney problems, eye or vision problems, bone marrow problems (eg, low blood platelet levels), an adrenal gland tumor (pheochromocytoma), carcinoid syndrome, liver problems, seizures, an overactive thyroid, or phenylketonuria
  • if you have a prolonged infection that is currently or has been previously treated with another antibiotic medicine
  • if you are taking any medicine for depression

Some MEDICINES MAY INTERACT with linezolid suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Amphetamines (eg, dextroamphetamine), anorexiants (eg, phentermine ), apraclonidine, beta-2 agonists (eg, albuterol), bupropion, buspirone, COMT inhibitors (eg, entacapone), cyclobenzaprine, dexmethylphenidate, dextromethorphan, fentanyl, ginseng, levodopa, MAOIs (eg, phenelzine, selegiline), meperidine, methylphenidate, nefazodone, norepinephrine reuptake inhibitors (eg, atomoxetine), propoxyphene, sibutramine , SNRIs (eg, duloxetine, venlafaxine), SSRIs (eg, fluoxetine, paroxetine), sympathomimetics (eg, pseudoephedrine), tetrabenazine, tetracyclic antidepressants (eg, maprotiline, mirtazapine), trazodone, tricyclic antidepressants (eg, amitriptyline, doxepin), triptans (eg, sumatriptan), tryptophan, or vilazodone because severe side effects, including severe headache, fever, high blood pressure, or mental or mood changes, may occur
  • Insulin or other diabetes medicines (eg, glyburide) because the risk of low blood sugar may be increased
  • Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), or rifamycins (eg, rifampin) because they may decrease linezolid suspension's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if linezolid suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use linezolid suspension:

Use linezolid suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take linezolid suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Gently mix before each dose by turning the bottle upside-down 3 to 5 times. Do not shake linezolid suspension.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • To clear up your infection completely, take linezolid suspension for the full course of treatment. Keep taking it even if you feel better in a few days.
  • If you miss a dose of linezolid suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use linezolid suspension.

Important safety information:

  • Linezolid suspension may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use linezolid suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Tell your doctor or dentist that you take linezolid suspension before you receive any medical or dental care, emergency care, or surgery.
  • Be sure to use linezolid suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of linezolid suspension may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Eating foods high in tyramine (eg, aged cheeses, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) while you use an MAOI may cause severe high blood pressure. This could occur for up to 2 weeks after you stop taking an MAOI. Do not eat foods high in tyramine while you take linezolid suspension. Ask your health care provider for a complete list of foods you should avoid. Seek medical attention at once if symptoms of severe high blood pressure occur. These may include severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light.
  • Linezolid suspension may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Linezolid suspension only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Lactic acidosis has occurred with the use of linezolid suspension. Contact your doctor if you have severe or persistent nausea, vomiting, stomach pain, or unusual tiredness or weakness.
  • Serious eye problems (eg, peripheral and optic neuropathy) have occurred with the use of linezolid suspension. Contact your doctor if you experience vision changes (eg, decreased or blurred vision, changes in color vision, loss of vision).
  • Phenylketonuria patients - Linezolid suspension contains phenylalanine. If you must have a diet that is low in phenylalanine, talk with your doctor or pharmacist.
  • Diabetes patients - Low blood sugar has been reported in patients taking linezolid suspension along with insulin or other diabetes medicines. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or nondiet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • Lab tests, including complete blood cell counts and eye exams, may be performed while you use linezolid suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using linezolid suspension while you are pregnant. It is not known if linezolid suspension is found in breast milk. If you are or will be breast-feeding while you use linezolid suspension, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of linezolid suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in mouth; constipation; diarrhea; dizziness; headache; nausea; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); agitation; bloody stools; bloody vomit; chills, fever, or sore throat; confusion; exaggerated reflexes; excitation; fast heartbeat; loss of coordination; mental or mood changes; muscle spasms; prolonged or repeated nausea or vomiting; red, swollen, peeling, or blistered skin; seizures; severe or continuing diarrhea; severe or persistent headache or dizziness; stomach pain/cramps; sweating; swelling of the hands or feet; tingling or numbness of the hands or feet; unusual bleeding or bruising; unusual tiredness or weakness; vaginal irritation or unusual discharge; vision changes; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of linezolid suspension:

Store linezolid suspension at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep the bottle tightly closed. Discard any unused medicine 21 days after mixing. Keep linezolid suspension out of the reach of children and away from pets.

General information:

  • If you have any questions about linezolid suspension, please talk with your doctor, pharmacist, or other health care provider.
  • Linezolid suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take linezolid suspension or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about linezolid suspension. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to linezolid suspension. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using linezolid suspension.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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