Linaclotide

Generic Name: linaclotide (lin-AK-loe-tide)
Brand Name: Linzess

Linaclotide should not be used in children younger than 18 years old; it may harm them. Discuss any questions or concerns with your doctor.


Linaclotide is used for:

Treating irritable bowel syndrome with constipation (IBS-C). It is also used to treat a certain type of constipation (chronic idiopathic constipation). Linaclotide may also be used for other conditions as determined by your doctor.

Linaclotide is a guanylate cyclase-C agonist. It works by increasing the amount of fluid in the intestines and causing the contents to move along more quickly.

Do NOT use linaclotide if:

  • you are allergic to any ingredient in linaclotide
  • you have known or suspected stomach or bowel blockage
  • the patient is a child younger than 18 years old

Contact your doctor or health care provider right away if any of these apply to you.

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Before using linaclotide:

Some medical conditions may interact with linaclotide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with linaclotide. However, no specific interactions with linaclotide are known at this time.

Ask your health care provider if linaclotide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use linaclotide:

Use linaclotide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Linaclotide comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get linaclotide refilled.
  • Take linaclotide by mouth on an empty stomach at least 30 minutes before the first meal of the day.
  • Swallow linaclotide whole. Do not break apart, crush, or chew before swallowing.
  • If you miss a dose of linaclotide, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use linaclotide.

Important safety information:

  • Diarrhea is a common side effect of linaclotide. If it occurs, it usually begins within the first 2 weeks after starting linaclotide. If you experience severe or persistent diarrhea, stop taking linaclotide and contact your doctor right away.
  • Tell your doctor or dentist that you take linaclotide before you receive any medical or dental care, emergency care, or surgery.
  • Linaclotide should not be used in CHILDREN younger than 18 years old; it may harm them.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using linaclotide while you are pregnant. It is not known if linaclotide is found in breast milk. If you are or will be breast-feeding while you use linaclotide, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of linaclotide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; stomach pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black tarry stools; severe or persistent diarrhea; swelling of the stomach (feeling of fullness or pressure in your stomach); unusual or severe stomach pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea.

Proper storage of linaclotide:

Store linaclotide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in the original container with the lid tightly closed, away from heat, moisture, and light. Do not remove the desiccant (drying agent) from the bottle. Do not store in the bathroom. Keep linaclotide out of the reach of children and away from pets.

General information:

  • If you have any questions about linaclotide, please talk with your doctor, pharmacist, or other health care provider.
  • Linaclotide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take linaclotide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about linaclotide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to linaclotide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using linaclotide.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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