Lidocaine/ prilocaine cream

Generic Name: lidocaine/prilocaine (LYE-doe-kane/PRIL-oh-kane)
Brand Name: EMLA

Lidocaine/ prilocaine cream is used for:

Relieving pain of normal intact skin and numbing skin to pain from injections and other medical procedures.

Lidocaine/prilocaine cream is a local anesthetic. It works by blocking nerves from transmitting painful impulses to the brain.

Do NOT use lidocaine/ prilocaine cream if:

  • you are allergic to any ingredient in lidocaine/prilocaine cream or to other similar medicines
  • you have the blood disorder methemoglobinemia

Contact your doctor or health care provider right away if any of these apply to you.

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Before using lidocaine/ prilocaine cream:

Some medical conditions may interact with lidocaine/prilocaine cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substance
  • if you have severe liver disease, glucose-6-phosphate dehydrogenase deficiency, or a perforated ear drum
  • if you have been ill

Some MEDICINES MAY INTERACT with lidocaine/prilocaine cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, amiodarone, dofetilide, mexiletine, tocainide), beta-blockers (eg, propranolol), cimetidine, or other medicines containing lidocaine or prilocaine because the risk of side effects or toxic effects, including heart or nerve problems, may be increased
  • Acetaminophen, acetanilid, aniline dyes (eg, p-phenylenediamine), benzocaine, chloroquine, dapsone, naphthalene, nitrates (eg, nitroglycerin, isosorbide), nitrites (eg, sodium nitrite), nitrofurantoin, nitroprusside, pamaquine, para-aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, quinine, or sulfonamides (eg, sulfamethoxazole) because the risk of side effects, including blood problems, may be increased
  • Succinylcholine because the risk of its side effects may be increased by lidocaine/prilocaine cream

This may not be a complete list of all interactions that may occur. Ask your health care provider if lidocaine/prilocaine cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use lidocaine/ prilocaine cream:

Use lidocaine/prilocaine cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with lidocaine/prilocaine cream. Talk to your pharmacist if you have questions about this information.
  • Wash and completely dry the area to be treated. Apply a thick layer of cream to the affected skin. Do not rub lidocaine/prilocaine cream into the skin.
  • Lidocaine/prilocaine cream should only be used on normal, unbroken skin. Do not apply to damaged skin.
  • Avoid getting lidocaine/prilocaine cream in your eyes, nose, or mouth. If you get lidocaine/prilocaine cream in your eyes, rinse them with plenty of water.
  • Wash your hands immediately after using lidocaine/prilocaine cream.
  • Discard unused medicine and packaging in the trash, out of the reach of children and away from pets.
  • If you miss a dose of lidocaine/prilocaine cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use lidocaine/prilocaine cream.

Important safety information:

  • Lidocaine/prilocaine cream blocks pain and feeling in the skin. Be careful not to injure the treated skin by scratching, rubbing, or coming into contact with extreme cold or heat.
  • Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Talk with your doctor before you receive any vaccine while you are using lidocaine/prilocaine cream.
  • Lidocaine/prilocaine cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
  • When using lidocaine/prilocaine cream on young children, be sure to closely watch the child to prevent the accidental swallowing of lidocaine/prilocaine cream.
  • Use lidocaine/prilocaine cream with caution in the ELDERLY; they may be more sensitive to its effects.
  • Caution is advised when using lidocaine/prilocaine cream in CHILDREN younger than 3 months old; they may be more sensitive to its effects, especially blood problems.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using lidocaine/prilocaine cream while you are pregnant. Lidocaine/prilocaine cream is found in breast milk. If you are or will be breast-feeding while you use lidocaine/prilocaine cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of lidocaine/ prilocaine cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; burning; change in hot or cold sensation; pale skin; redness or swelling at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; dizziness; nervousness; seizures; slow heartbeat; unusual drowsiness. Lidocaine/prilocaine cream may be harmful if swallowed.

Proper storage of lidocaine/prilocaine cream:

Store lidocaine/prilocaine cream at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep lidocaine/prilocaine cream out of the reach of children and away from pets.

General information:

  • If you have any questions about lidocaine/prilocaine cream, please talk with your doctor, pharmacist, or other health care provider.
  • Lidocaine/prilocaine cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take lidocaine/prilocaine cream or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about lidocaine/prilocaine cream. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to lidocaine/prilocaine cream. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using lidocaine/prilocaine cream.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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