Generic Name: lomitapide (loe-MI-ta-pide)
Brand Name: Juxtapid
Juxtapid may increase the risk of liver problems. The risk may be greater if you already have liver problems. Liver function tests will be performed while you use Juxtapid to check for side effects. Contact your doctor right away if you experience dark urine; fever; flu-like symptoms; nausea, vomiting, or stomach pain that gets worse, does not go away, or changes; pale stools; unusual tiredness; or yellowing of the skin or eyes.
Juxtapid is used for:
Lowering high cholesterol in certain patients. It is used along with an appropriate diet and other cholesterol treatments.
Juxtapid is a lipid-lowering agent. It works by preventing the production of cholesterol.
Do NOT use Juxtapid if:
- you are allergic to any ingredient in Juxtapid
- you are pregnant, think you may be pregnant, or are planning to become pregnant
- you have moderate to severe liver problems or unexplained abnormal liver function tests
- you have certain hereditary problems (eg, galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption)
- you are taking aprepitant, azole antifungals (eg, fluconazole, itraconazole, voriconazole), ciprofloxacin, clarithromycin, conivaptan, crizotinib, diltiazem, erythromycin, fosaprepitant, imatinib, mibefradil, nefazodone, protease inhibitors (eg, boceprevir, ritonavir), telithromycin, or verapamil
Contact your doctor or health care provider right away if any of these apply to you.
Before using Juxtapid:
Some medical conditions may interact with Juxtapid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you are on dialysis or have a history of kidney problems, liver problems (eg, liver problems while taking other medicines), stomach or bowel problems, or pancreas problems
- if you drink alcohol
- if you take medicines that may harm the liver (eg, acetaminophen, amiodarone, isotretinoin, methotrexate, tamoxifen, tetracycline antibiotics). Ask your doctor if you are unsure if any of your medicines might harm the liver
Some MEDICINES MAY INTERACT with Juxtapid. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Many prescription and nonprescription medicines (eg, used for aches and pains, acne, allergies, anxiety, asthma, birth control, blood clotting problems, blood thinning, blood vessel problems, cancer, depression or other mental or mood problems, diabetes, gout, high blood pressure, high cholesterol, HIV, immune system suppression, indigestion or reflux, infections, irregular heartbeat or other heart problems, low blood sodium levels, pulmonary arterial hypertension [PAH], rheumatoid arthritis, sleep, stomach or bowel problems), multivitamin products, and herbal or dietary supplements (eg, ginkgo, goldenseal, St. John's wort) because they may interact with Juxtapid. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with Juxtapid
This may not be a complete list of all interactions that may occur. Ask your health care provider if Juxtapid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Juxtapid:
Use Juxtapid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Juxtapid comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Juxtapid refilled.
- Take Juxtapid by mouth on an empty stomach at least 2 hours after the evening meal. Taking Juxtapid with food may cause stomach problems.
- Swallow Juxtapid whole with a glass of water. Do not open, crush, dissolve, or chew before swallowing. If you cannot swallow Juxtapid whole, tell your doctor. You may need a different medicine.
- Do not eat grapefruit or drink grapefruit juice while you use Juxtapid.
- If you also take cholestyramine, colesevelam, or colestipol, do not take it within 4 hours before or after taking Juxtapid. Check with your doctor if you have questions.
- If you miss a dose of Juxtapid, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking Juxtapid for more than a week, contact your doctor before you start to take it again.
Ask your health care provider any questions you may have about how to use Juxtapid.
Important safety information:
- Dizziness may occur while you take Juxtapid. Use Juxtapid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do NOT change your dose or stop taking Juxtapid without checking with your doctor.
- Follow the low-fat diet given to you by your health care provider. This may help to decrease the risk of stomach or bowel problems.
- You may need to take certain dietary supplements (eg, vitamin E, fatty acids) while taking Juxtapid. Be sure to follow the directions provided by your doctor.
- Drinking alcohol while taking Juxtapid may increase the risk of liver problems. Do not drink more than 1 drink with alcohol in it per day while you are taking Juxtapid. Discuss any questions or concerns with your doctor.
- If vomiting or diarrhea occurs, the effectiveness of other oral medicines may be affected. If you take birth control pills and you develop vomiting or diarrhea, you will need to use an extra form of birth control (eg, condoms). Contact your doctor if you develop vomiting or diarrhea while taking Juxtapid.
- If you may become pregnant, you must have a negative pregnancy test before beginning treatment with Juxtapid. You must also use an effective form of birth control while you take Juxtapid. If you have questions about effective birth control or if you have any questions or concerns, talk with your doctor.
- Lab tests, including liver function, may be performed while you use Juxtapid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Juxtapid should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Do not use Juxtapid if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Juxtapid is found in breast milk. Do not breast-feed while taking Juxtapid.
Possible side effects of Juxtapid:
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; gas; indigestion; mild stomach cramps, pain, or discomfort; nausea; tiredness; vomiting; weight loss.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; irregular heartbeat; severe or persistent nausea, vomiting, diarrhea, or stomach pain; stomach swelling; symptoms of liver problems (eg, dark urine; fever; flu-like symptoms; stomach pain that gets worse, does not go away, or changes; pale stools; unusual tiredness; yellowing of the skin or eyes).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Juxtapid:
Store Juxtapid at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a tightly-closed container away from heat, moisture, and light. Do not store in the bathroom. Keep Juxtapid out of the reach of children and away from pets.
- If you have any questions about Juxtapid, please talk with your doctor, pharmacist, or other health care provider.
- Juxtapid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Juxtapid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Juxtapid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Juxtapid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Juxtapid.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.