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Itraconazole solution

Pronunciation

Generic Name: itraconazole (IT-ra-KON-a-zole)
Brand Name: Sporanox

Contact your doctor immediately if you experience symptoms of congestive heart failure, such as swelling of the hands, ankles, or feet; shortness of breath; or sudden, unexplained weight gain.

Use of itraconazole solution along with certain other medicines may increase the risk of their side effects. This may include serious and sometimes fatal heart problems (eg, irregular heartbeat). Do not take itraconazole solution if you are also taking cisapride, disopyramide, dofetilide, dronedarone, eplerenone, ergot alkaloids (eg, dihydroergotamine, ergotamine, methylergonovine), felodipine, irinotecan, levacetylmethadol (levomethadyl), lovastatin, lurasidone, methadone, oral midazolam, nisoldipine, pimozide, quinidine, ranolazine, simvastatin, or triazolam. If you have kidney or liver problems, do not take itraconazole solution if you are also taking a medicine that contains colchicine. Check with your doctor or pharmacist if you are not sure if a medicine you take contains colchicine.


Itraconazole solution is used for:

Treating fungal infections of the mouth, throat, or esophagus. It may also be used for other conditions as determined by your doctor.

Itraconazole solution is an azole antifungal. It works by killing sensitive fungi.

Do NOT use itraconazole solution if:

  • you are allergic to any ingredient in itraconazole solution
  • you are taking cisapride, disopyramide, dofetilide, dronedarone, eplerenone, an ergot alkaloid (eg, dihydroergotamine, ergotamine, methylergonovine), felodipine, irinotecan, levacetylmethadol (levomethadyl), lovastatin, lurasidone, methadone, oral midazolam, nisoldipine, pimozide, quinidine, ranolazine, simvastatin, or triazolam
  • you are taking a medicine that contains colchicine and you also have kidney or liver problems. Check with your doctor or pharmacist if you are not sure if a medicine you take contains colchicine

Contact your doctor or health care provider right away if any of these apply to you.

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Before using itraconazole solution:

Some medical conditions may interact with itraconazole solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to other azole antifungals (eg, ketoconazole)
  • if you have HIV infection, a weakened immune system, low white blood cell levels, cystic fibrosis, kidney or liver problems, abnormal liver function tests, lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD]), low stomach acid (eg, hypochlorhydria), nerve problems, or problems with swelling or retaining fluid
  • if you have an irregular heartbeat or other heart problems (eg, congestive heart failure, coronary artery disease, heart valve problems)
  • if you have had serious liver problems caused by itraconazole solution or other medicines

Some MEDICINES MAY INTERACT with itraconazole solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for allergies; anxiety, depression, or other mental or mood problems; asthma or other lung or breathing problems; blood thinning; blood vessel problems; cancer; Cushing syndrome; cystic fibrosis; diabetes; emergency contraception; erectile dysfunction; gout; heartburn; hepatitis C virus infection; high blood pressure; high cholesterol; HIV infection; hormonal birth control, such as birth control pills; immune system suppression; infections; inflammation; irregular heartbeat or other heart problems; migraine headaches; nausea and vomiting; overactive bladder or other urinary problems; pain; parathyroid gland problems; prostate problems, ; seizures; sleep), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) because they may interact with itraconazole solution. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with itraconazole solution.

This may not be a complete list of all interactions that may occur. Ask your health care provider if itraconazole solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use itraconazole solution:

Use itraconazole solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take itraconazole solution on an empty stomach at least 1 hour before or 2 hours after eating, if possible.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you are using itraconazole solution to treat a mouth, throat, or esophageal infection, swish itraconazole solution in your mouth for several seconds before swallowing, unless directed otherwise by your doctor.
  • To clear up your infection completely, take itraconazole solution for the full course of treatment. Keep taking it even if you feel better in a few days. Do not miss any doses.
  • Itraconazole solution works best if it is taken at the same time each day.
  • If you miss a dose of itraconazole solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use itraconazole solution.

Important safety information:

  • Itraconazole solution may cause dizziness or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use itraconazole solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. If you have dizziness or vision changes, do not drive or perform other possibly unsafe tasks.
  • Rarely, itraconazole solution has been associated with serious, sometimes fatal liver problems, including some cases within the first week of treatment. Contact your doctor right away if you notice dark urine; loss of appetite; pale stools; severe stomach pain; unusual tiredness, nausea, or vomiting; or yellowing of the skin or eyes.
  • Hearing loss has been reported in patients taking itraconazole solution. Many of these cases have occurred when itraconazole solution has been taken along with quinidine. The hearing loss usually goes away when itraconazole solution is stopped but may persist in some patients. Discuss any questions or concerns with your doctor.
  • Itraconazole solution only works against fungi; it does not treat viral infections (eg, the common cold).
  • Be sure to use itraconazole solution for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Itraconazole solution may interact with many other medicines. This includes how well itraconazole solution works or increased side effects. Sometimes this may lead to life-threatening effects or sudden death. Be sure your doctor and pharmacist know all of the medicines that you take.
  • Do not switch between the capsule and oral solution forms of itraconazole solution without checking with your doctor. Effectiveness and side effects of these forms of itraconazole solution may be different even at the same dose.
  • Diabetes patients - Itraconazole solution may increase the risk of low blood sugar from your diabetes medicine. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using itraconazole solution. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • If you are using itraconazole solution to treat a fungal infection of the toenail or fingernail, you should use an effective form of birth control while you are taking itraconazole solution and for 2 months after you have stopped treatment. Talk with your doctor about effective forms of birth control.
  • Tell your doctor or dentist that you take itraconazole solution before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including liver function, may be performed while you use itraconazole solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use itraconazole solution with caution in the ELDERLY; they may be more sensitive to its effects, especially loss of hearing.
  • Itraconazole solution should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if itraconazole solution can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using itraconazole solution while you are pregnant. Itraconazole solution is found in breast milk. If you are or will be breast-feeding while you use itraconazole solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of itraconazole solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; gas; headache; indigestion; mild stomach pain; nausea; runny nose; stomach upset; unpleasant taste; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; breast growth or pain; changes in the amount of urine produced or uncontrolled urination; chest pain; coughing up white or pink mucus; decreased sexual ability; depression; difficulty swallowing; fainting; fast or irregular heartbeat; fever, chills, or persistent cough or sore throat; hair loss; joint pain; loss of hearing; menstrual problems; muscle pain, weakness, or cramping; numbness, burning, or tingling of the hands, arms, legs, or feet; red, swollen, blistered, or peeling skin; ringing in the ears; sensitivity to sunlight; severe or persistent dizziness; severe stomach or back pain (with or without nausea or vomiting); shortness of breath; sudden, unexplained weight changes; swelling of the hands, ankles, or feet; symptoms of liver problems (eg, dark urine; loss of appetite; pale stools; severe stomach pain; unusual tiredness, nausea, or vomiting; yellowing of the skin or eyes); tremors; trouble sleeping; unusual bruising or bleeding; unusual tiredness or fatigue; very dry mouth or eyes; vision problems (eg, blurred vision, double vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of itraconazole solution:

Store itraconazole solution below 77 degrees F (25 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep itraconazole solution out of the reach of children and away from pets.

General information:

  • If you have any questions about itraconazole solution, please talk with your doctor, pharmacist, or other health care provider.
  • Itraconazole solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take itraconazole solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about itraconazole solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to itraconazole solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using itraconazole solution.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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