Itraconazole capsules

Pronunciation

Generic Name: itraconazole (IT-ra-KON-a-zole)
Brand Name: Sporanox

Itraconazole capsules should not be used to treat a fungal infection of the toenail or fingernail (onychomycosis) in patients with heart failure or in those who have a history of it. Contact your doctor immediately if you experience symptoms of congestive heart failure, such as swelling of the hands, ankles, or feet; shortness of breath; or sudden, unexplained weight gain.

Use of itraconazole capsules along with certain other medicines may increase the risk of their side effects. This may include serious and sometimes fatal heart problems (eg, irregular heartbeat). Do not take itraconazole capsules if you are also taking cisapride, dofetilide, ergot alkaloids (eg, dihydroergotamine, ergotamine, methylergonovine), felodipine, levacetylmethadol (levomethadyl), lovastatin, methadone, oral midazolam, nisoldipine, pimozide, quinidine, simvastatin, or triazolam.


Itraconazole capsules is used for:

Treating fungal infections. It may also be used for other conditions as determined by your doctor.

Itraconazole capsules is an azole antifungal. It works by killing sensitive fungi.

Do NOT use itraconazole capsules if:

  • you are allergic to any ingredient in itraconazole capsules
  • you are being treated for a fungal infection of the toenail or fingernail (onychomycosis) and you also have heart failure, are pregnant, may become pregnant, or have a history of heart failure
  • you are taking alfuzosin, aliskiren, alprazolam, apixaban, astemizole, cabazitaxel, cisapride, conivaptan, crizotinib, dofetilide, domperidone, dronedarone, eplerenone, an ergot alkaloid (eg, dihydroergotamine, ergotamine, methylergonovine), erythromycin, everolimus, felodipine, ivabradine, levacetylmethadol (levomethadyl), lovastatin, lurasidone, methadone, oral midazolam, nevirapine, nisoldipine, pimozide, quinidine, ranolazine, rifabutin, rifampin, rivaroxaban, salmeterol, silodosin, simvastatin, sirolimus, tamsulosin, terfenadine, ticagrelor, tolvaptan, or triazolam

Contact your doctor or health care provider right away if any of these apply to you.

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Before using itraconazole capsules:

Some medical conditions may interact with itraconazole capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to other azole antifungals (eg, ketoconazole)
  • if you have HIV infection, a weakened immune system, kidney or liver problems, abnormal liver function tests, lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD]), low stomach acid (eg, hypochlorhydria), nerve problems, or problems with swelling or retaining fluid
  • if you have an irregular heartbeat or other heart problems (eg, congestive heart failure, coronary artery disease, heart valve problems)
  • if you have had serious liver problems caused by itraconazole capsules or other medicines

Some MEDICINES MAY INTERACT with itraconazole capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for allergies; anxiety, depression, or other mental or mood problems; asthma or other lung or breathing problems; blood thinning; blood vessel problems; cancer; Cushing syndrome; cystic fibrosis; diabetes; emergency contraception; erectile dysfunction; gout; heartburn; hepatitis C virus infection; high blood pressure; high cholesterol; HIV infection; hormonal birth control, such as birth control pills; immune system suppression; infections; inflammation; irregular heartbeat or other heart problems; migraine headaches; nausea and vomiting; overactive bladder or other urinary problems; pain; parathyroid gland problems; prostate problems; seizures; sleep), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, gingko, St. John's wort) because they may interact with itraconazole capsules. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with itraconazole capsules.

This may not be a complete list of all interactions that may occur. Ask your health care provider if itraconazole capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use itraconazole capsules:

Use itraconazole capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take itraconazole capsules after a full meal. If you have low stomach acid or you take medicine to reduce stomach acid, take itraconazole capsules with a cola beverage.
  • Do not take antacids within 1 hour before or 2 hours after taking itraconazole capsules.
  • Do not take eletriptan within 72 hours after taking itraconazole capsules.
  • If you take didanosine or a proton pump inhibitor (eg, omeprazole), ask your doctor or pharmacist how to take it with itraconazole capsules.
  • To clear up your infection completely, take itraconazole capsules for the full course of treatment. Keep taking it even if you feel better in a few days. Do not miss any doses.
  • Itraconazole capsules works best if it is taken at the same time each day.
  • If you miss a dose of itraconazole capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use itraconazole capsules.

Important safety information:

  • Itraconazole capsules may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use itraconazole capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Rarely, itraconazole capsules has been associated with serious, sometimes fatal liver problems, including some cases within the first week of treatment. Contact your doctor right away if you notice dark urine; loss of appetite; pale stools; severe stomach pain; unusual tiredness, nausea, or vomiting; or yellowing of the skin or eyes.
  • Hearing loss has been reported in patients taking itraconazole capsules. Many of these cases have occurred when itraconazole capsules has been taken along with quinidine. The hearing loss usually goes away when itraconazole capsules is stopped but may persist in some patients. Discuss any questions or concerns with your doctor.
  • Itraconazole capsules only works against fungi; it does not treat viral infections (eg, the common cold).
  • Be sure to use itraconazole capsules for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Do not switch between the capsule and oral solution forms of itraconazole capsules without checking with your doctor. Effectiveness and side effects of these forms of itraconazole capsules may be different even at the same dose.
  • Diabetes patients - Itraconazole capsules may increase the risk of low blood sugar from your diabetes medicine. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using itraconazole capsules. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • If you are using itraconazole capsules to treat a fungal infection of the toenail or fingernail, you should use an effective form of birth control while you are taking itraconazole capsules and for 2 months after you have stopped treatment. Talk with your doctor about effective forms of birth control.
  • Tell your doctor or dentist that you take itraconazole capsules before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including liver function, may be performed while you use itraconazole capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use itraconazole capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially loss of hearing.
  • Itraconazole capsules should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if itraconazole capsules can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using itraconazole capsules while you are pregnant. Itraconazole capsules is found in breast milk. If you are or will be breast-feeding while you use itraconazole capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of itraconazole capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; gas; headache; indigestion; mild stomach pain; nausea; runny nose; stomach upset; unpleasant taste; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; breast growth or pain; changes in the amount of urine produced or uncontrolled urination; chest pain; coughing up white or pink mucus; decreased sexual ability; depression; difficulty swallowing; fainting; fast or irregular heartbeat; fever, chills, or persistent cough or sore throat; hair loss; joint pain; loss of hearing; menstrual problems; muscle pain, weakness, or cramping; numbness, burning, or tingling of the hands, arms, legs, or feet; red, swollen, blistered, or peeling skin; ringing in the ears; sensitivity to sunlight; severe or persistent dizziness; severe stomach or back pain (with or without nausea or vomiting); shortness of breath; sudden, unexplained weight changes; swelling of the hands, ankles, or feet; symptoms of liver problems (eg, dark urine; loss of appetite; pale stools; severe stomach pain; unusual tiredness, nausea, or vomiting; yellowing of the skin or eyes); tremors; trouble sleeping; unusual bruising or bleeding; unusual tiredness or fatigue; very dry mouth or eyes; vision problems (eg, blurred vision, double vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of itraconazole capsules:

Store itraconazole capsules at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep itraconazole capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about itraconazole capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Itraconazole capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take itraconazole capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about itraconazole capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to itraconazole capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using itraconazole capsules.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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