Isosorbide dinitrate

Pronunciation

Generic Name: isosorbide dinitrate (EYE-soe-SOR-bide dye-NYE-trate)
Brand Name: Isordil Titradose

Isosorbide dinitrate is used for:

Preventing symptoms of angina (chest pain) caused by heart disease. Isosorbide dinitrate is used alone or with other medicines. Isosorbide dinitrate is NOT intended for the immediate relief of acute attacks of angina. It may also be used for other conditions as determined by your doctor.

Isosorbide dinitrate is a nitrate. It works by relaxing the blood vessels in the body, allowing them to widen. This lets more blood flow through the blood vessels, which reduces the work the heart has to do to pump blood. This reduces the oxygen needs of the heart and decreases chest pain.

Do NOT use isosorbide dinitrate if:

  • you are allergic to any ingredient in isosorbide dinitrate
  • you are taking avanafil, riociguat, sildenafil, tadalafil, or vardenafil

Contact your doctor or health care provider right away if any of these apply to you.

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Before using isosorbide dinitrate:

Some medical conditions may interact with isosorbide dinitrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bleeding in the brain, a recent head trauma, an overactive thyroid, heart problems (eg, heart failure, cardiomyopathy, history of heart attack), or anemia (a low red blood cell count)

Some MEDICINES MAY INTERACT with isosorbide dinitrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Avanafil, riociguat, sildenafil, tadalafil, or vardenafil because the risk of severe low blood pressure may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if isosorbide dinitrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use isosorbide dinitrate:

Use isosorbide dinitrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take isosorbide dinitrate by mouth on an empty stomach with a full glass of water (8 oz [240 mL]).
  • If you miss a dose of isosorbide dinitrate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use isosorbide dinitrate.

Important safety information:

  • Isosorbide dinitrate may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use isosorbide dinitrate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Isosorbide dinitrate may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Check with your doctor before you drink alcohol while you are taking isosorbide dinitrate. Drinking alcohol may increase the risk of low blood pressure with isosorbide dinitrate.
  • Isosorbide dinitrate may give you daily headaches. This should become less noticeable with time. Do not change how you use isosorbide dinitrate to avoid these headaches. Talk with your doctor for ways to lessen this side effect.
  • Isosorbide dinitrate should not be used to stop an attack of angina; it is intended only for prevention of an attack.
  • Isosorbide dinitrate may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking isosorbide dinitrate.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using isosorbide dinitrate while you are pregnant. It is not known if isosorbide dinitrate is found in breast milk. If you are or will be breast-feeding while you use isosorbide dinitrate, check with your doctor. Discuss any possible risks to your baby.

When used for long periods of time without a break, isosorbide dinitrate may not work as well. This is known as TOLERANCE. Increasing the dose is not effective in managing tolerance to isosorbide dinitrate. Tolerance to other nitrates or nitrites may also occur. Be sure to have a "nitrate-free" period of time each day to help prevent this tolerance. Talk with your doctor if isosorbide dinitrate stops working well. Do not take more than prescribed.

Some people who use isosorbide dinitrate for a long time without a break may develop a physical need to continue taking it. This is known as physical DEPENDENCE. If you take isosorbide dinitrate without a break and then suddenly stop taking it, you may get WITHDRAWAL symptoms. These may include chest pain, heart attack, or possibly sudden death. Be sure to have a "nitrate-free" period of time each day; this may help prevent dependence and withdrawal problems.

Possible side effects of isosorbide dinitrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; flushing of the face and neck; headache; light-headedness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; fast or slow heartbeat; nausea; new or worsening chest pain; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of isosorbide dinitrate:

Store isosorbide dinitrate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep isosorbide dinitrate out of the reach of children and away from pets.

General information:

  • If you have any questions about isosorbide dinitrate, please talk with your doctor, pharmacist, or other health care provider.
  • Isosorbide dinitrate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take isosorbide dinitrate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about isosorbide dinitrate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to isosorbide dinitrate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using isosorbide dinitrate.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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