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Isordil Titradose

Generic Name: isosorbide dinitrate (eye-soe-SOR-bide dye-NYE-trate)
Brand Name: Isordil Titradose

Isordil Titradose is used for:

Preventing symptoms of angina (chest pain) caused by heart disease. Isordil Titradose is used alone or with other medicines. Isordil Titradose is NOT intended for the immediate relief of acute attacks of angina. It may also be used for other conditions as determined by your doctor.

Isordil Titradose is a nitrate. It works by relaxing the blood vessels in the body, allowing them to widen. This lets more blood flow through the blood vessels, which reduces the work the heart has to do to pump blood. This reduces the oxygen needs of the heart and decreases chest pain.

Do NOT use Isordil Titradose if:

  • you are allergic to any ingredient in Isordil Titradose
  • you are taking a phosphodiesterase type 5 inhibitor (eg, sildenafil), a medicine often used for sexual dysfunction

Contact your doctor or health care provider right away if any of these apply to you.

Before using Isordil Titradose:

Some medical conditions may interact with Isordil Titradose. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bleeding in the brain, a recent head trauma, an overactive thyroid, heart problems (eg, heart failure, cardiomyopathy, history of heart attack), or anemia (a low red blood cell count)

Some MEDICINES MAY INTERACT with Isordil Titradose. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Ethanol or phosphodiesterase type 5 inhibitors (eg, sildenafil) because side effects, such as extremely low blood pressure, dizziness, or fainting, may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Isordil Titradose may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Isordil Titradose:

Use Isordil Titradose as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Isordil Titradose by mouth on an empty stomach with a full glass of water (8 oz/240 mL).
  • If you miss a dose of Isordil Titradose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Isordil Titradose.

Important safety information:

  • Isordil Titradose may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Isordil Titradose with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Isordil Titradose may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • When you begin taking Isordil Titradose, it may give you a headache. This usually becomes less noticeable with time. This is a sign that the medicine is working. Do not change your dosing schedule to avoid headaches. Take aspirin or acetaminophen with Isordil Titradose to avoid headaches.
  • Isordil Titradose should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Isordil Titradose while you are pregnant. It is not known if Isordil Titradose is found in breast milk. If you are or will be breast-feeding while you use Isordil Titradose, check with your doctor. Discuss any possible risks to your baby.

When used for long periods of time without a break, Isordil Titradose may not work as well. This is known as TOLERANCE. Increasing the dose is not effective in managing tolerance to Isordil Titradose. Tolerance to other nitrates or nitrites may also occur. Be sure to have a "nitrate-free" period of time each day to help prevent this tolerance. Talk with your doctor if Isordil Titradose stops working well. Do not take more than prescribed.

Some people who use Isordil Titradose for a long time without a break may develop a physical need to continue taking it. This is known as physical DEPENDENCE. If you take Isordil Titradose without a break and then suddenly stop taking it, you may get WITHDRAWAL symptoms. These may include chest pain, heart attack, or possibly sudden death. Be sure to have a "nitrate-free" period of time each day; this may help prevent dependence and withdrawal problems.

Possible side effects of Isordil Titradose:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; flushing of the face and neck; headache; lightheadedness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; frequent, continuing, or severe chest pain; nausea; rapid or slow heartbeat; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; diarrhea; difficulty breathing; dizziness; headache; irregular and/or forceful heartbeat; loss of consciousness; nausea; seizures; slow pulse; stomach pain; sweating; vision problems; vomiting.

Proper storage of Isordil Titradose:

Store Isordil Titradose at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Isordil Titradose out of the reach of children and away from pets.

General information:

  • If you have any questions about Isordil Titradose, please talk with your doctor, pharmacist, or other health care provider.
  • Isordil Titradose is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Isordil Titradose or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Isordil Titradose. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Isordil Titradose. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Isordil Titradose.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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