Consumer Drug Information

Innohep


Generic Name: Tinzaparin (tin-ZAP-a-rin)
Brand Name: Innohep

Tell your doctor you use Innohep before you have any type of spinal puncture or epidural/spinal anesthesia. Patients who have these procedures while they use Innohep are at risk for developing a blood clot on or near the spinal cord. This could result in long-term or permanent paralysis.

The risk is increased in patients who have an indwelling epidural catheter, or traumatic or repeated epidural or spinal puncture, and in patients who use medicines that may affect blood clotting such as warfarin, aspirin, platelet inhibitors (eg, clopidogrel), and nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen).

If you have a spinal puncture or epidural/spinal anesthesia while you use Innohep , tell your doctor immediately if you notice any signs or symptoms of nerve problems such as numbness or tingling, muscle weakness, or paralysis.


Innohep is used for:

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Treating certain types of blood clots (deep vein thrombosis) when used along with warfarin.

Innohep is an anticoagulant. It works by blocking the formation of blood clots, including fibrin clots.

Do NOT use Innohep if:

  • you are allergic to any ingredient in Innohep
  • you are allergic to heparin, sulfites, benzyl alcohol, or pork products
  • you have active severe high blood pressure, major bleeding, or a history of low platelets or bleeding problems due to the use of heparin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Innohep :

Some medical conditions may interact with Innohep . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems, liver problems or intestinal disease
  • if you have inflammation of the heart due to a bacterial infection, severe, uncontrolled high blood pressure, amyloidosis, or ulcers
  • if you have a history of stroke, asthma, or vision problems caused by diabetes
  • if you have a bleeding disorder or a history of brain bleeding or blood conditions
  • if you have recently had or are scheduled to have brain, spine, or eye surgery, an epidural catheter, or a spinal puncture
  • if you are taking medicines that affect platelets (eg, aspirin, clopidogrel, ticlopidine)
  • if you are 70 years old or older and have decreased kidney function

Some MEDICINES MAY INTERACT with Innohep . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nitrates (eg, nitroglycerin) or streptokinase because they may decrease the effectiveness of Innohep
  • Activated protein C, anticoagulants (eg, warfarin), dextran, dipyridamole, direct factor XA inhibitors (eg, rivaroxaban), direct thrombin inhibitors (eg, dabigatran), injectable cephalosporins (eg, cephazolin), injectable penicillins (eg, ampicillin), NSAIDs (eg, ibuprofen), platelet inhibitors (eg, clopidogrel, ticlopidine), salicylates (eg, aspirin), sulfinpyrazone, or thrombolytics (eg, alteplase) because the risk of side effects, such as bleeding, may be increased
  • Sulfonylureas (eg, glyburide) because their actions and side effects may be increased, resulting in low blood sugar

This may not be a complete list of all interactions that may occur. Ask your health care provider if Innohep may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.



How to use Innohep :

Use Innohep as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Innohep is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Innohep at home, carefully follow the injection procedures taught to you by your health care provider.
  • Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into the muscle or a vein.
  • Do not use Innohep if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Innohep , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Innohep .

Important safety information:

  • Innohep may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Innohep with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.
  • Innohep may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Innohep may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.
  • Tell your doctor or dentist that you take Innohep before you receive any medical or dental care, emergency care, or surgery.
  • Before you begin taking any new prescription or nonprescription medicine, check the label to see if it has aspirin or ibuprofen in it. If it does or you are not sure, contact your doctor or pharmacist.
  • Lab tests, including complete blood cell counts, may be performed while you use Innohep . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Innohep with caution in the ELDERLY; the risk of death may be greater in patients 70 years old and older who have decreased kidney function. Discuss any concerns with your doctor.
  • Innohep has benzyl alcohol in it. Do not use it in NEWBORNS or INFANTS. It may cause serious and sometimes fatal nervous system problems and other side effects.
  • Innohep should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Innohep while you are pregnant. It is not known if Innohep is found in breast milk. If you are or will be breast-feeding while you use Innohep , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Innohep :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bruising; irritation or bleeding at the injection site; pain, swelling, redness, or bruising at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody, black, or tarry stools; chest pain; confusion; difficulty breathing or swallowing; difficulty urinating; difficulty walking; fever, chills or sore throat; joint or muscle pain; leg weakness; nosebleed; numbness or tingling of the skin; pink or red urine; prolonged, painful erection; red, swollen, blistered or peeling skin; severe or persistent dizziness or weakness; severe or persistent headache; shortness of breath; swelling; unusual bleeding or bruising.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include unusual bleeding or bruising (eg, nosebleeds, easy bruising).

Proper storage of Innohep :

Store Innohep at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Innohep out of the reach of children and away from pets.

General information:

  • If you have any questions about Innohep , please talk with your doctor, pharmacist, or other health care provider.
  • Innohep is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Innohep . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 4, 2009
Database Edition 09.4.1.002
Copyright © 2009 Wolters Kluwer Health, Inc.

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