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Indinavir

Generic Name: indinavir (in-DIN-a-vir)
Brand Name: Crixivan

Indinavir is used for:

Treating HIV infection in combination with certain other medicines.

Indinavir is an HIV protease inhibitor. It works by blocking the growth of HIV.

Do NOT use indinavir if:

  • you are allergic to any ingredient in indinavir
  • you are taking alfuzosin, amiodarone, apixaban, astemizole, atazanavir, certain benzodiazepines (eg, alprazolam, oral midazolam, triazolam), cabazitaxel, cisapride, conivaptan, crizotinib, dronedarone, an ergot alkaloid (eg, ergonovine, ergotamine), erythromycin, ivabradine, lovastatin, lurasidone, nilotinib, pimozide, a proton pump inhibitor (eg, omeprazole), ranolazine, rifampin, rivaroxaban, salmeterol, a serotonin 5-HT1 receptor antagonist (eg, eletriptan, sumatriptan), silodosin, simvastatin, St. John's wort, tamsulosin, terfenadine, ticagrelor, or tolvaptan
  • you are taking sildenafil for pulmonary arterial hypertension (PAH)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using indinavir:

Some medical conditions may interact with indinavir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems (eg, cirrhosis), kidney problems, diabetes, high blood sugar, high cholesterol, kidney stones, urinary problems (eg, white blood cells in the urine), or certain blood problems (eg, hemophilia, hemolytic anemia)

Some MEDICINES MAY INTERACT with indinavir. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many other prescription and nonprescription medicines (eg, used for aches or pain, allergies, asthma or other lung or breathing problems, blood thinning, blood vessel problems, cancer, Cushing syndrome, cystic fibrosis, depression or other mental or mood problems, diabetes, erectile dysfunction, gout, high blood pressure, high cholesterol, HIV infection, immune suppression, infections, inflammation, insomnia, irregular heartbeat or other heart problems, migraine headaches, narcotic addiction, nausea or vomiting, overactive bladder, PAH, seizures, stomach or bowel problems), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with indinavir. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with indinavir

This may not be a complete list of all interactions that may occur. Ask your health care provider if indinavir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use indinavir:

Use indinavir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with indinavir. Talk to your pharmacist if you have questions about this information.
  • Take indinavir by mouth on an empty stomach at least 1 hour before or 2 hours after eating. You may also take it with a light meal that is low in calories, fat, and protein. Take indinavir with water. You may also take it with other liquids such as skim or nonfat milk, juice, coffee, or tea.
  • Drinking extra fluids while you are taking indinavir is recommended. You should drink at least 48 oz (1.5 L) of water a day unless otherwise directed by your doctor.
  • If you take didanosine, ask your doctor or pharmacist how to take it with indinavir.
  • Large amounts of garlic may decrease the effectiveness of indinavir. Talk with your doctor before including garlic in your diet.
  • Take indinavir on a regular schedule every 8 hours around the clock, unless your doctor tells you otherwise.
  • Take indinavir on a regular schedule to get the most benefit from it. Taking indinavir at the same time each day will help you remember to take it.
  • Continue to take indinavir even if you feel well. Do not miss any doses.
  • If you miss a dose of indinavir by more than 2 hours, do not take that dose. Take your next dose as scheduled. If you miss the dose by less than 2 hours, take that dose immediately and then return to your regular dosing schedule. It is important not to miss doses of indinavir. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use indinavir.

Important safety information:

  • Indinavir may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use indinavir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Keep a list of all the medicines that you take. Make a new list each time a medicine is added or stopped. Find out about medicines that should not be taken while you are taking indinavir. Be sure that each of your health care providers knows all the medicines that you are taking.
  • Indinavir is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
  • Indinavir does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.
  • Do NOT take more than the recommended dose, change the dose, or stop taking indinavir without checking with your doctor.
  • When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking indinavir, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
  • Indinavir may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start indinavir.
  • Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking indinavir. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.
  • Indinavir may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Hemophilia patients - Some people with hemophilia have developed increased bleeding while taking protease inhibitors, such as indinavir. Report all bleeding episodes to your doctor.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using indinavir. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Lab tests, including liver function, cholesterol, complete blood cell counts, and CD4 counts, may be performed while you use indinavir. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Indinavir should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • Caution is advised when using indinavir in CHILDREN; they may be more sensitive to its effects, especially kidney stones.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using indinavir while you are pregnant. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or indinavir to the baby. It is not known if indinavir is found in breast milk.

Possible side effects of indinavir:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in the mouth; diarrhea; dizziness; drowsiness; headache; mild stomach pain or upset; nausea; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back, flank, or side pain; bloody or cloudy urine; change in the amount of urine produced; changes in appetite; chest, jaw, or arm pain; chills; confusion; dark urine; depression; fainting; fever; heartburn; ingrown toenails; joint pain; loss of appetite; numbness of the mouth; one-sided numbness or weakness; pain while urinating; pale stools; red, swollen, blistered, or peeling skin; severe or persistent stomach pain or upset; shortness of breath; speech problems; sudden, unusual sweating; swelling of the stomach; unusual hair loss; unusual paleness; unusual tiredness or weakness; unusually dry skin; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include back, flank, or side pain; blood in the urine; diarrhea; nausea; vomiting.

Proper storage of indinavir:

Store indinavir at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in the original bottle. Store away from heat, moisture, and light. Do not store in the bathroom. Leave the desiccant in the bottle. Do not eat the desiccant. Keep indinavir out of the reach of children and away from pets.

General information:

  • If you have any questions about indinavir, please talk with your doctor, pharmacist, or other health care provider.
  • Indinavir is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take indinavir or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about indinavir. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to indinavir. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using indinavir.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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