Ifosfamide and mesna

Generic Name: ifosfamide and mesna (eye-FOS-fa-mide/MES-na)
Brand Name: Ifex and Mesnex

Ifosfamide and mesna should only be used under the supervision of a doctor experienced with the use of cancer medicines. Bladder effects (eg, bleeding, inflammation) or central nervous system effects (eg, confusion, coma) may occur with use of ifosfamide and mesna. Contact your doctor immediately if you experience any of these symptoms. Ifosfamide and mesna may also cause bone marrow depression.


Ifosfamide and mesna is used for:

Treating certain types of cancer in combination with other medicines.

Ifosfamide and mesna is an antineoplastic and urinary protectant combination. It works by stopping the growth of certain cancers and by lowering the risk of bleeding in your bladder.

Do NOT use ifosfamide and mesna if:

  • you are allergic to any ingredient in ifosfamide and mesna
  • you have severe bone marrow depression
  • you are in your first 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

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Before using ifosfamide and mesna:

Some medical conditions may interact with ifosfamide and mesna. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney problems, bone marrow problems, cancer that has spread to the bone marrow, an infection, chickenpox, or shingles
  • if you have had radiation therapy or have received other chemotherapy medicines

Some MEDICINES MAY INTERACT with ifosfamide and mesna. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin because its effectiveness may be decreased by ifosfamide and mesna

This may not be a complete list of all interactions that may occur. Ask your health care provider if ifosfamide and mesna may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ifosfamide and mesna:

Use ifosfamide and mesna as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ifosfamide and mesna is usually given as an injection at your doctor's office, hospital, or clinic.
  • Do not use ifosfamide and mesna if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Drinking extra fluids while you are taking ifosfamide and mesna is recommended. Check with your doctor for instructions.
  • If your skin comes into contact with ifosfamide and mesna, wash the skin immediately with soap and water. If a mucous membrane (eg, lips, tongue, nostrils) comes into contact with ifosfamide and mesna, rinse thoroughly with water.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of ifosfamide and mesna, contact your doctor right away for dosing instructions.

Ask your health care provider any questions you may have about how to use ifosfamide and mesna.

Important safety information:

  • Ifosfamide and mesna may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use ifosfamide and mesna with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Empty your bladder regularly. Your doctor may recommend that you get up at least once during the night to urinate.
  • Ifosfamide and mesna may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding.
  • Ifosfamide and mesna may decrease your body's ability to heal itself. To prevent wounds, avoid situations where bruising or injury may occur.
  • Ifosfamide and mesna may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • If nausea, vomiting, or loss of appetite occurs, ask your doctor, nurse, or pharmacist for ways to lessen these effects.
  • Check with your doctor before having vaccinations while you are using ifosfamide and mesna.
  • Ifosfamide and mesna has benzyl alcohol in it. Do not use it in NEWBORNS or INFANTS. It may cause serious and sometimes fatal nervous system problems and other side effects.
  • Lab tests, including kidney function, complete blood cell count, other blood tests, and urine tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use ifosfamide and mesna with caution in the ELDERLY; they may be more sensitive to its effects.
  • Use ifosfamide and mesna with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Ifosfamide and mesna has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using ifosfamide and mesna while you are pregnant. Ifosfamide and mesna is found in breast milk. Do not breast-feed while using ifosfamide and mesna.

Possible side effects of ifosfamide and mesna:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Hair loss; loss of appetite; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine or dark urine; coma; confusion; decrease in the amount of urine produced; dizziness; fever, chills, sore throat, or cough; hallucinations; irregular or absent menstrual periods; joint pain; mental or mood changes; painful or frequent urination; seizures; shortness of breath; sleepiness; sores on the mouth or lips; stomach pain; unusual bruising or bleeding; unusual fatigue; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of ifosfamide and mesna:

Ifosfamide and mesna is usually handled and stored by a health care provider. If you are using ifosfamide and mesna at home, store ifosfamide and mesna as directed by your pharmacist or health care provider. Keep ifosfamide and mesna, as well as needles and syringes, out of the reach of children and away from pets.

General information:

  • If you have any questions about ifosfamide and mesna, please talk with your doctor, pharmacist, or other health care provider.
  • Ifosfamide and mesna is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take ifosfamide and mesna or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ifosfamide and mesna. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ifosfamide and mesna. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using ifosfamide and mesna.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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