Knee Problem? Assess your knee pain and find relief.

Ibuprofen/ famotidine

Generic Name: ibuprofen/famotidine (EYE-bue-PROE-fen/fam-OH-ti-deen)
Brand Name: Duexis

Ibuprofen/famotidine contains a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take ibuprofen/famotidine for a long time. Do not use ibuprofen/famotidine right before or after bypass heart surgery.

Ibuprofen/famotidine may cause an increased risk of serious and sometimes fatal stomach or bowel ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.


Ibuprofen/ famotidine is used for:

Treating rheumatoid arthritis and osteoarthritis. It is also used to decrease the risk of developing stomach or bowel ulcers in patients using ibuprofen to treat these conditions. It may also be used for other conditions as determined by your doctor.

Ibuprofen/famotidine is an NSAID and H2 (histamine) blocker combination. Exactly how the NSAID works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms. The H2 blocker works to reduce stomach acid by blocking one of the chemicals (histamine) that stimulates the release of acid into the stomach.

Do NOT use ibuprofen/ famotidine if:

  • you are allergic to any ingredient in ibuprofen/famotidine or to another H2 blocker (eg, ranitidine)
  • you have had an asthma attack or a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) after taking aspirin or an NSAID (eg, naproxen, celecoxib)
  • you have recently had or will be having bypass heart surgery
  • you have moderate to severe kidney problems
  • you are 30 weeks pregnant or more
  • you are taking dasatinib

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment Options for Rheumatoid Arthritis

Doctor Ariel D. Teitel discusses several treatments that can help control the progression of the disease and help to alleviate the swelling and pain.

Before using ibuprofen/ famotidine:

Some medical conditions may interact with ibuprofen/famotidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers, inflammation)
  • if you have a history of swelling or fluid buildup, a connective tissue disease (eg, lupus), asthma, growths in the nose (nasal polyps), or mouth inflammation
  • if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
  • if you have poor health, dehydration or low fluid volume, swelling or fluid retention, or low blood sodium levels; you drink alcohol or smoke; or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with ibuprofen/famotidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), antiplatelet medicines (eg, clopidogrel), bisphosphonates (eg, alendronate), aspirin, corticosteroids (eg, prednisone), dabigatran, desirudin, heparin, low molecular weight heparins (LMWHs) (eg, enoxaparin), other NSAIDs (eg, naproxen), salicylates (eg, aspirin), rivaroxaban, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach or bowel bleeding or irritation may be increased
  • Probenecid because it may increase the risk of ibuprofen/famotidine's side effects
  • Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by ibuprofen/famotidine
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), dasatinib, diuretics (eg, furosemide, hydrochlorothiazide), itraconazole, or ketoconazole because their effectiveness may be decreased by ibuprofen/famotidine

This may not be a complete list of all interactions that may occur. Ask your health care provider if ibuprofen/famotidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ibuprofen/ famotidine:

Use ibuprofen/famotidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ibuprofen/famotidine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get ibuprofen/famotidine refilled.
  • Take ibuprofen/famotidine by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
  • Swallow ibuprofen/famotidine whole. Do not break, crush, or chew before swallowing.
  • If you take cholestyramine, erlotinib, itraconazole, or ketoconazole, ask your doctor or pharmacist how to take it with ibuprofen/famotidine.
  • Take ibuprofen/famotidine with a full glass of water (8 oz/240 mL) as directed by your doctor.
  • If you miss a dose of ibuprofen/famotidine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of ibuprofen/famotidine.

Important safety information:

  • Ibuprofen/famotidine may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use ibuprofen/famotidine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Serious stomach ulcers or bleeding can occur with the use of ibuprofen/famotidine. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking ibuprofen/famotidine with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
  • Do NOT take more than the recommended dose, use for longer than prescribed, or stop taking ibuprofen/famotidine without checking with your doctor.
  • Ibuprofen/famotidine has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen or any other NSAID (eg, naproxen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do not take aspirin while you are taking ibuprofen/famotidine unless your doctor tells you to.
  • Lab tests, including kidney or liver function, complete blood cell counts, and blood pressure, may be performed while you use ibuprofen/famotidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use ibuprofen/famotidine with caution in the ELDERLY; they may be more sensitive to its effects, including stomach or bowel bleeding and kidney problems.
  • Ibuprofen/famotidine should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Ibuprofen/famotidine may cause harm to the fetus. Do not take it if you are 30 weeks pregnant or more. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking ibuprofen/famotidine while you are pregnant. Ibuprofen/famotidine is found in breast milk. Do not breast-feed while taking ibuprofen/famotidine.

Possible side effects of ibuprofen/ famotidine:

All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; mild stomach pain or upset; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); blisters or sores in the mouth; bloody or black, tarry stools; change in the amount of urine produced; chest, jaw, or left arm pain; confusion; fainting; fever, chills, or persistent sore throat; irregular heartbeat; loss of balance or coordination; mental or mood changes (eg, depression); numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; seizures; severe headache, dizziness, or drowsiness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; slurred speech; stiff neck; sudden cold sweat; sudden or unexplained weight gain; swelling of hands, legs, or feet; symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; flu-like symptoms; itching; right upper stomach pain; unusual tiredness, loss of appetite, or nausea); trouble walking; unusual bruising or bleeding; unusual joint or muscle pain; unusual sensitivity to light; unusual tiredness or weakness; vision changes (eg, blurred vision, color vision changes, blind spots); vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe nausea or stomach pain; slow or troubled breathing; unusual bleeding or bruising; unusual eye movements; vomit that looks like coffee grounds.

Proper storage of ibuprofen/famotidine:

Store ibuprofen/famotidine at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep ibuprofen/famotidine out of the reach of children and away from pets.

General information:

  • If you have any questions about ibuprofen/famotidine, please talk with your doctor, pharmacist, or other health care provider.
  • Ibuprofen/famotidine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take ibuprofen/famotidine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ibuprofen/famotidine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ibuprofen/famotidine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using ibuprofen/famotidine.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Hide
(web3)