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Hydrocortisone/ diphenhydramine spray

Generic Name: hydrocortisone/diphenhydramine (HYE-droe-KOR-ti-sone/DYE-fen-HYE-dra-meen)
Brand Name: HC DermaPax

Hydrocortisone/ diphenhydramine spray is used for:

Treating inflammation and itching caused by minor skin irritations (eg, poison ivy, poison oak, insect bites). It may also be used for other conditions as determined by your doctor.

Hydrocortisone/diphenhydramine spray contains a topical corticosteroid and an antihistamine. The corticosteroid works by reducing skin inflammation (redness, swelling, itching, and irritation). The antihistamine works by blocking the action of histamine, which reduces the symptoms of an allergic reaction.

Do NOT use hydrocortisone/ diphenhydramine spray if:

  • you are allergic to any ingredient in hydrocortisone/diphenhydramine spray

Contact your doctor or health care provider right away if this applies to you.

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Before using hydrocortisone/ diphenhydramine spray:

Some medical conditions may interact with hydrocortisone/diphenhydramine spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have any kind of skin infection, cuts, scrapes, sunburn, or lessened blood flow to your skin
  • if you have had a recent vaccination; have measles, tuberculosis (TB), chickenpox, or shingles; or have had a positive TB test
  • if you have a history of the blood disease porphyria
  • if you are taking prednisone or similar medicines

Some MEDICINES MAY INTERACT with hydrocortisone/diphenhydramine spray. However, no specific interactions with hydrocortisone/diphenhydramine spray are known at this time.

Ask your health care provider if hydrocortisone/diphenhydramine spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use hydrocortisone/ diphenhydramine spray:

Use hydrocortisone/diphenhydramine spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Apply a small amount of medicine to the affected area as directed by your doctor or on the package labeling.
  • Wash your hands after you apply hydrocortisone/diphenhydramine spray, unless your hands are part of the treated area.
  • Do not bandage or cover the treated skin area unless directed by your doctor.
  • If you miss a dose of hydrocortisone/diphenhydramine spray and you are using it regularly, apply it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not apply 2 doses at once.

Ask your health care provider any questions you may have about how to use hydrocortisone/diphenhydramine spray.

Important safety information:

  • Hydrocortisone/diphenhydramine spray is for external use only. Do not get hydrocortisone/diphenhydramine spray in your eyes, nose, or mouth. If you get it in any of these areas, rinse right away with cool water.
  • Do not use hydrocortisone/diphenhydramine spray on the face, in the groin area, or under the armpits. Do not use hydrocortisone/diphenhydramine spray to treat diaper rash.
  • Do not use more than the recommended dose or use for longer than 7 days without checking with your doctor.
  • If your symptoms do not get better within 7 days, if they get worse, or if they clear up and then come back, check with your doctor.
  • Check with your doctor before you have any vaccines while you are using hydrocortisone/diphenhydramine spray.
  • Do not use hydrocortisone/diphenhydramine spray for other skin conditions at a later time.
  • Do not use other medicines or products on your skin without first checking with your doctor.
  • Overuse of topical products may worsen your condition.
  • Hydrocortisone/diphenhydramine spray has hydrocortisone and diphenhydramine in it. Before you start any new prescription or nonprescription medicine, check the label to see if it has hydrocortisone or diphenhydramine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Tell your doctor or dentist that you take hydrocortisone/diphenhydramine spray before you receive any medical or dental care, emergency care, or surgery.
  • Serious side effects may occur if too much of hydrocortisone/diphenhydramine spray is absorbed through the skin. This may be more likely to occur if you use hydrocortisone/diphenhydramine spray over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply hydrocortisone/diphenhydramine spray. The risk is greater in children. Do not use more than the recommended dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.
  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use hydrocortisone/diphenhydramine spray.
  • Hydrocortisone/diphenhydramine spray should not be used in CHILDREN younger than 2 years old without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using hydrocortisone/diphenhydramine spray while you are pregnant. It is not known if hydrocortisone/diphenhydramine spray is found in breast milk after topical use. If you are or will be breast-feeding while you use hydrocortisone/diphenhydramine spray, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of hydrocortisone/ diphenhydramine spray:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; mild stinging, burning, or itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; burning, cracking, irritation, or peeling not present before you began using hydrocortisone/diphenhydramine spray; excessive hair growth; inflamed hair follicles; inflammation around the mouth; thinning, softening, or discoloration of the skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face.

Proper storage of hydrocortisone/diphenhydramine spray:

Store hydrocortisone/diphenhydramine spray at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not freeze. Do not store in the bathroom. Keep hydrocortisone/diphenhydramine spray out of the reach of children and away from pets.

General information:

  • If you have any questions about hydrocortisone/diphenhydramine spray, please talk with your doctor, pharmacist, or other health care provider.
  • Hydrocortisone/diphenhydramine spray is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take hydrocortisone/diphenhydramine spray or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about hydrocortisone/diphenhydramine spray. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to hydrocortisone/diphenhydramine spray. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using hydrocortisone/diphenhydramine spray.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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