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Hydrochlorothiazide/ timolol

Generic Name: hydrochlorothiazide/timolol (hye-droe-klor-oh-THYE-a-zide/TIM-oh-lole)
Brand Name: Timolide

Do not suddenly stop taking hydrochlorothiazide/timolol. Sharp chest pain, irregular heartbeat, and sometimes heart attack may occur if you suddenly stop hydrochlorothiazide/timolol. The risk may be greater if you have certain types of heart disease. Your doctor should slowly lower your dose over several weeks if you need to stop taking it. This should be done even if you only take hydrochlorothiazide/timolol for high blood pressure. Heart disease is common and you may not know you have it. Limit physical activity while you are lowering your dose. If new or worsened chest pain or other heart problems occur, contact your doctor right away. You may need to start taking hydrochlorothiazide/timolol again.


Hydrochlorothiazide/ timolol is used for:

Treating high blood pressure.

Hydrochlorothiazide/timolol is a beta-blocker and diuretic combination. It works by decreasing the force and slowing down the heartbeat, helping the heart beat more regularly and reducing the amount of work the heart has to do. It also increases the elimination of excessive fluid, which helps to decrease blood pressure.

Do NOT use hydrochlorothiazide/ timolol if:

  • you are allergic to any ingredient in hydrochlorothiazide/timolol or to sulfonamide medicines (eg, sulfamethoxazole, probenecid, glyburide)
  • you have uncontrolled heart failure, heart block, heart shock, a very slow heart rate, or low blood pressure
  • you are unable to urinate or have a history of asthma or severe chronic obstructive pulmonary disease (COPD)
  • you are taking other beta-blockers (eg, propranolol), dofetilide, or mibefradil

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update: First Time Brand-to-Generic Switches

Before using hydrochlorothiazide/ timolol:

Some medical conditions may interact with hydrochlorothiazide/timolol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of bronchitis, lung disease (eg, COPD), diabetes, gout, an overactive thyroid, heart problems (eg, congestive heart failure), blood vessel problems, pheochromocytoma, lupus, liver disease, kidney problems, or abnormal blood electrolyte (eg, potassium sodium) levels
  • if you are having surgery, receiving anesthesia, or you are dehydrated

Some MEDICINES MAY INTERACT with hydrochlorothiazide/timolol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Barbiturates (eg, phenobarbital), cimetidine, clonidine, corticosteroids (eg, prednisone), guanethidine, other beta-blockers (eg, propranolol), or reserpine because they may increase the risk of hydrochlorothiazide/timolol's side effects
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenytoin, or rifampin because they may decrease hydrochlorothiazide/timolol's effectiveness
  • Antiarrhythmics (eg, disopyramide), calcium channel blockers (eg, verapamil, diltiazem), or cimetidine because side effects, such as slow or irregular heart beat or low blood pressure, may occur
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), barbiturates (eg, phenobarbital), chlorpromazine, clonidine, diazoxide, flecainide, mefloquine, mibefradil, narcotics (eg, codeine), or nifedipine because the risk of side effects of both medicines may be increased
  • Allopurinol, amantadine, digitalis (eg, digoxin), dofetilide, insulin or other medicines for diabetes (eg, glyburide), ketanserin, lithium, theophylline, or thyroxine because the risk of their side effects may be increased by hydrochlorothiazide/timolol

This may not be a complete list of all interactions that may occur. Ask your health care provider if hydrochlorothiazide/timolol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use hydrochlorothiazide/ timolol:

Use hydrochlorothiazide/timolol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take hydrochlorothiazide/timolol by mouth with or without food.
  • If you also take cholestyramine or colestipol, do not take them within 1 before or 2 hours after taking hydrochlorothiazide/timolol. Check with your doctor if you have questions.
  • Hydrochlorothiazide/timolol may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of hydrochlorothiazide/timolol, take the missed dose if you remember the same day. Skip the missed dose if you do not remember the same day. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use hydrochlorothiazide/timolol.

Important safety information:

  • Hydrochlorothiazide/timolol may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use hydrochlorothiazide/timolol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Hydrochlorothiazide/timolol may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Hydrochlorothiazide/timolol may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to hydrochlorothiazide/timolol. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take hydrochlorothiazide/timolol before you receive any medical or dental care, emergency care, or surgery.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Diabetes patients - Hydrochlorothiazide/timolol may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Hydrochlorothiazide/timolol may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking hydrochlorothiazide/timolol.
  • Lab tests, including blood pressure, blood electrolyte levels, and heart rate, may be performed while you use hydrochlorothiazide/timolol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use hydrochlorothiazide/timolol with caution in the ELDERLY; they may be more sensitive to its effects.
  • Hydrochlorothiazide/timolol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using hydrochlorothiazide/timolol while you are pregnant. Hydrochlorothiazide/timolol is found in breast milk. Do not breast-feed while taking hydrochlorothiazide/timolol.

Possible side effects of hydrochlorothiazide/ timolol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; dizziness; drowsiness; lightheadedness; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decreased urination; dry mouth; loss of consciousness; muscle pain or weakness; nausea; slow or irregular heartbeat; swelling of ankles or feet; tremors; unusual thirst or fatigue; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coughing; dizziness; drowsiness; fainting; loss of consciousness; muscular weakness; nausea; seizures; slow heartbeat; trouble breathing; upset stomach; vomiting; weakness.

Proper storage of hydrochlorothiazide/timolol:

Store hydrochlorothiazide/timolol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep hydrochlorothiazide/timolol out of the reach of children and away from pets.

General information:

  • If you have any questions about hydrochlorothiazide/timolol, please talk with your doctor, pharmacist, or other health care provider.
  • Hydrochlorothiazide/timolol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about hydrochlorothiazide/timolol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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