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Generic Name: hyaluronate sodium (HYE-a-loo-RON-ate SOE-dee-um)
Brand Name: Examples include Hyalgan and Supartz

Hyalgan is used for:

Treating knee pain in patients with osteoarthritis who have not received relief from other treatments.

Hyalgan is a hyaluronic acid derivative. It works by increasing the effectiveness of the fluid within the knee joint to act as a lubricant and shock absorber.

Do NOT use Hyalgan if:

  • you are allergic to any ingredient in Hyalgan or to similar medicines
  • you have a knee joint infection, or an infection or skin disease around the injection site

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update - First Time Brand-to-Generic Switches

Before using Hyalgan:

Some medical conditions may interact with Hyalgan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to birds or bird products (eg, eggs, feathers, poultry)
  • if you have received another injectable medicine in the same joint into which Hyalgan will be injected

Some MEDICINES MAY INTERACT with Hyalgan. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Quaternary ammonium salts (eg, benzalkonium chloride) because side effects may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hyalgan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hyalgan:

Use Hyalgan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Hyalgan. Talk to your pharmacist if you have questions about this information.
  • Hyalgan is given as an injection into the knee joint at your doctor's office, hospital, or clinic.
  • Hyalgan is usually given as a series of injections 1 week apart for a total of 3 to 5 injections depending upon the particular product you are using. You may not experience relief until you have received several injections.
  • Do not use Hyalgan if it contains particles, is cloudy or discolored, or if the vial or syringe is cracked or damaged.
  • Do not use disinfectants containing ammonium salts to prepare the skin for injection because side effects may occur.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Hyalgan, contact your doctor to establish a new dosing schedule.

Ask your health care provider any questions you may have about how to use Hyalgan.

Important safety information:

  • Someone may need to drive you home from the doctor's office, hospital, or clinic after you receive Hyalgan. Discuss any questions or concerns with your doctor.
  • You may experience a temporary inflammation in your knee after using Hyalgan. If the inflammation is severe or continues, contact your doctor.
  • Avoid strenuous activity or prolonged (more than 1 hour) weight-bearing activity (eg, running, tennis, heavy lifting, standing on your feet) for at least 48 hours after you are injected with Hyalgan. Ask your doctor when you should begin physical activities again.
  • Hyalgan should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Hyalgan, contact your doctor. You will need to discuss the benefits and risks of using Hyalgan while you are pregnant. It is not known if Hyalgan is found in breast milk. If you are or will be breast-feeding while you use Hyalgan, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hyalgan:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; mild bruising, redness, or pain at the injection site; mild stiffness, swelling, warmth, or pain in or around the injected knee; muscle or joint pain; temporary achy feeling.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent headache or dizziness; severe, persistent, or painful swelling of the injected joint.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Hyalgan:

Hyalgan is usually handled and stored by a health care provider. If you are using Hyalgan at home, store Hyalgan as directed by your pharmacist or health care provider. Keep Hyalgan out of the reach of children and away from pets.

General information:

  • If you have any questions about Hyalgan, please talk with your doctor, pharmacist, or other health care provider.
  • Hyalgan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Hyalgan or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Hyalgan. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Hyalgan. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Hyalgan.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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