Glyset

Generic Name: miglitol (MIG-li-tol)
Brand Name: Glyset

Glyset is used for:

Treating type 2 diabetes in adults. It is used along with diet and exercise. Glyset may be used alone or in combination with other diabetes medicines (eg, insulin).

Glyset is a glucosidase inhibitor. It works by slowing down the digestion of carbohydrates into glucose. This results in a smaller rise in blood sugar levels following a meal.

Do NOT use Glyset if:

  • you are allergic to any ingredient in Glyset
  • you have blockage of the bowel or if you are at risk for this problem
  • you have inflammatory bowel disease, colon ulcers, or long-term (chronic) bowel problems that interfere with digestion or nutrient absorption
  • you have diabetic ketoacidosis (high ketone levels) or severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Glyset:

Some medical conditions may interact with Glyset. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have stomach or bowel problems, liver problems, or kidney problems

Some MEDICINES MAY INTERACT with Glyset. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Insulin or sulfonylureas (eg, glyburide) because they may increase the risk of low blood sugar levels
  • Digoxin, propranolol, or ranitidine because their effectiveness may be decreased by Glyset

This may not be a complete list of all interactions that may occur. Ask your health care provider if Glyset may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Glyset:

Use Glyset as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Glyset by mouth at the start (with the first bite) of each main meal, unless directed otherwise by your doctor.
  • If you are also taking charcoal or digestive enzyme preparations (eg, amylase, pancreatin), ask your doctor or pharmacist how to take them with Glyset.
  • If you miss a dose of Glyset, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Glyset.

Important safety information:

  • Proper diet, regular exercise, and regular blood sugar testing are important for best results with Glyset. Follow the diet and exercise program given to you by your health care provider.
  • Tell your doctor or dentist that you take Glyset before you receive any medical or dental care, emergency care, or surgery.
  • Carefully follow the regular testing of urine or blood glucose schedules given to you by your health care provider.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • It may be harder to control your blood sugar during times of stress, such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.
  • Glyset does not usually cause low blood sugar. However, low blood sugar may occur when it is used along with certain other medicines for diabetes (eg, insulin, sulfonylureas). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. This will raise your blood sugar level quickly. Because Glyset prevents the breakdown of table (cane) sugar, be sure to use glucose (dextrose), not sugar or fruits, to treat symptoms of low blood sugar. Tell your doctor right away if this happens.
  • Lab tests, including blood glucose and glycosylated hemoglobin levels, may be performed while you use Glyset. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Glyset with should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Glyset while you are pregnant. Glyset is found in breast milk. Do not breast-feed while taking Glyset.

Possible side effects of Glyset:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloating; diarrhea; gas; soft stools; stomach pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; severe or persistent constipation, diarrhea, or nausea; severe stomach pain or bloating.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe or persistent diarrhea, gas, or stomach pain or discomfort.

Proper storage of Glyset:

Store Glyset at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Glyset out of the reach of children and away from pets.

General information:

  • If you have any questions about Glyset, please talk with your doctor, pharmacist, or other health care provider.
  • Glyset is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Glyset or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Glyset. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Glyset. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Glyset.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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