Generic Name: fluconazole (floo-KON-a-zole)
Brand Name: Diflucan
Fluconazole is used for:
Treating and preventing certain yeast and fungal infections. It may also be used for other conditions as determined by your doctor.
Fluconazole is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.
Do NOT use fluconazole if:
- you are allergic to any ingredient in fluconazole
- you are taking astemizole, cisapride, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, quinidine, terfenadine, or voriconazole
Contact your doctor or health care provider right away if any of these apply to you.
Before using fluconazole:
Some medical conditions may interact with fluconazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had an allergic reaction to another azole antifungal (eg, itraconazole)
- if you have a history of liver or kidney problems, or heart problems (eg, irregular heartbeat, structural heart problems)
- if you have a weakened immune system, HIV infection, diabetes, cancer, or blood electrolyte problems (eg, low blood potassium or magnesium levels)
Some MEDICINES MAY INTERACT with fluconazole. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Antiarrhythmics (eg, amiodarone, quinidine, sotalol), arsenic, astemizole, cisapride, domperidone, macrolide antibiotics (eg, erythromycin), pimozide, quinolones (eg, levofloxacin), serotonin (5-HT1) receptor agonists (eg, eletriptan), terfenadine, or vandetanib because the risk of severe irregular heartbeat (eg, QT prolongation) may be increased
- Rifabutin because the risk of certain eye problems (eg, uveitis) may be increased
- Macrolide immunosuppressants (eg, sirolimus, tacrolimus) because the risk of kidney problems may be increased
- Proton pump inhibitors (PPIs) (eg, omeprazole) or rifamycins (eg, rifampin) because they may decrease fluconazole's effectiveness
- Hormonal birth control (eg, birth control pills) or losartan because their effectiveness may be decreased by fluconazole
- Amphotericin B, anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam, midazolam), buspirone, certain calcium channel blockers (eg, amlodipine, felodipine, nifedipine), carbamazepine, colchicine, cyclophosphamide, cyclosporine, eplerenone, ergot alkaloids (eg, ergotamine), everolimus, fentanyl, halofantrine, haloperidol, certain HMG-CoA reductase inhibitors or "statins" (eg, atorvastatin, fluvastatin, simvastatin), hydantoins (eg, phenytoin), lurasidone, methadone, muscarinic antagonists (eg, solifenacin, tolterodine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen), prednisone, ramelteon, ranolazine, sulfonylureas (eg, glipizide, glyburide, tolbutamide), theophylline, tolvaptan, tretinoin, tricyclic antidepressants (eg, amitriptyline), vinca alkaloids (eg, vinblastine, vincristine), voriconazole, or zidovudine because the risk of their side effects may be increased by fluconazole
This may not be a complete list of all interactions that may occur. Ask your health care provider if fluconazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use fluconazole:
Use fluconazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take fluconazole by mouth with or without food.
- Take fluconazole at least 2 hours before PPIs (eg, omeprazole).
- To clear up your infection completely, take fluconazole for the full course of treatment. Keep taking it even if you feel better in a few days. Do not miss any doses.
- Fluconazole works best if it is taken at the same time each day.
- If you miss a dose of fluconazole, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use fluconazole.
Important safety information:
- Fluconazole may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use fluconazole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Fluconazole has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by fluconazole has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when fluconazole is stopped. Contact your doctor right away if you experience dark urine, loss of appetite, pale stools, severe stomach pain, or yellowing of the skin or eyes.
- If your symptoms do not get better within a few days or if they get worse, check with your doctor.
- Fluconazole only works against fungi; it does not treat viral infections (eg, the common cold) or bacterial infections.
- Tell your doctor or dentist that you take fluconazole before you receive any medical or dental care, emergency care, or surgery.
- Be sure to use fluconazole for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- If you develop a rash while you take fluconazole, contact your doctor.
- Long-term or repeated use of fluconazole may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using fluconazole. To prevent pregnancy, use an extra form of birth control (eg, condoms).
- Lab tests, including liver and kidney function, may be performed while you use fluconazole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use fluconazole with caution in the ELDERLY; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: Fluconazole may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking fluconazole while you are pregnant. Fluconazole is found in breast milk. If you are or will be breast-feeding while you use fluconazole, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of fluconazole:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Changes in taste; diarrhea; dizziness; headache; indigestion; mild stomach pain; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; wheezing); burning, numbness, or tingling; dark urine; fever, chills, or persistent sore throat; irregular heartbeat; loss of appetite; muscle pain, weakness, or cramping; pale stools; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea, nausea, or vomiting; swelling of the hands; unusual bruising or bleeding; unusual or severe stomach pain; unusual tiredness; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include changes in behavior; hallucinations.Proper storage of fluconazole:
Store fluconazole below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep fluconazole out of the reach of children and away from pets.
- If you have any questions about fluconazole, please talk with your doctor, pharmacist, or other health care provider.
- Fluconazole is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take fluconazole or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about fluconazole. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to fluconazole. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using fluconazole.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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