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Fluconazole solution

Pronunciation

Generic Name: fluconazole (floo-KON-a-zole)
Brand Name: Diflucan

Fluconazole solution is used for:

Treating and preventing certain yeast and fungal infections. It may also be used for other conditions as determined by your doctor.

Fluconazole solution is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.

Do NOT use fluconazole solution if:

  • you are allergic to any ingredient in fluconazole solution
  • you are taking astemizole, cisapride, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, quinidine, terfenadine, or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

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Before using fluconazole solution:

Some medical conditions may interact with fluconazole solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had an allergic reaction to another azole antifungal (eg, itraconazole)
  • if you have a history of liver or kidney problems, or heart problems (eg, irregular heartbeat, structural heart problems)
  • if you have a weakened immune system, HIV infection, diabetes, cancer, or blood electrolyte problems (eg, low blood potassium or magnesium levels)

Some MEDICINES MAY INTERACT with fluconazole solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, amiodarone, quinidine, sotalol), arsenic, astemizole, cisapride, domperidone, macrolide antibiotics (eg, erythromycin), pimozide, quinolones (eg, levofloxacin), serotonin (5-HT1) receptor agonists (eg, eletriptan), terfenadine, or vandetanib because the risk of severe irregular heartbeat (eg, QT prolongation) may be increased
  • Rifabutin because the risk of certain eye problems (eg, uveitis) may be increased
  • Macrolide immunosuppressants (eg, sirolimus, tacrolimus) because the risk of kidney problems may be increased
  • Proton pump inhibitors (eg, omeprazole) or rifamycins (eg, rifampin) because they may decrease fluconazole solution's effectiveness
  • Hormonal birth control (eg, birth control pills) or losartan because their effectiveness may be decreased by fluconazole solution
  • Amphotericin B, anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam, midazolam), buspirone, certain calcium channel blockers (eg, amlodipine, felodipine, nifedipine), carbamazepine, colchicine, cyclophosphamide, cyclosporine, eplerenone, ergot alkaloids (eg, ergotamine), everolimus, fentanyl, halofantrine, haloperidol, certain HMG-CoA reductase inhibitors or "statins" (eg, atorvastatin, fluvastatin, simvastatin), hydantoins (eg, phenytoin), lurasidone, methadone, muscarinic antagonists (eg, solifenacin, tolterodine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen), prednisone, ramelteon, ranolazine, sulfonylureas (eg, glipizide, glyburide, tolbutamide), theophylline, tolvaptan, tretinoin, tricyclic antidepressants (eg, amitriptyline), vinca alkaloids (eg, vinblastine, vincristine), voriconazole, or zidovudine because the risk of their side effects may be increased by fluconazole solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if fluconazole solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use fluconazole solution:

Use fluconazole solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Fluconazole solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using fluconazole solution at home, a health care provider will teach you how to use it. Be sure you understand how to use fluconazole solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use fluconazole solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • To clear up your infection completely, use fluconazole solution for the full course of treatment. Keep using it even if you feel better in a few days. Do not miss any doses.
  • Fluconazole solution works best if it is taken at the same time each day.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of fluconazole solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use fluconazole solution.

Important safety information:

  • Fluconazole solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use fluconazole solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Fluconazole solution has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by fluconazole solution has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when fluconazole solution is stopped. Contact your doctor right away if you experience dark urine, loss of appetite, pale stools, severe stomach pain, or yellowing of the skin or eyes.
  • If your symptoms do not get better within a few days or if they get worse, check with your doctor.
  • Fluconazole solution only works against fungi; it does not treat viral infections (eg, the common cold) or bacterial infections.
  • Tell your doctor or dentist that you take fluconazole solution before you receive any medical or dental care, emergency care, or surgery.
  • Be sure to use fluconazole solution for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • If you develop a rash while you take fluconazole solution, contact your doctor.
  • Long-term or repeated use of fluconazole solution may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using fluconazole solution. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Lab tests, including liver and kidney function, may be performed while you use fluconazole solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use fluconazole solution with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: Fluconazole solution may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using fluconazole solution while you are pregnant. Fluconazole solution is found in breast milk. If you are or will be breast-feeding while you use fluconazole solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of fluconazole solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste; diarrhea; dizziness; headache; indigestion; mild stomach pain; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; wheezing); burning, numbness, or tingling; dark urine; fever, chills, or persistent sore throat; irregular heartbeat; loss of appetite; muscle pain, weakness, or cramping; pale stools; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea, nausea, or vomiting; swelling of the hands; unusual bruising or bleeding; unusual or severe stomach pain; unusual tiredness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include changes in behavior; hallucinations.

Proper storage of fluconazole solution:

Fluconazole solution is usually handled and stored by a health care provider. If you are using fluconazole solution at home, store fluconazole solution as directed by your pharmacist or health care provider. Keep fluconazole solution, as well as syringes and needles, out of the reach of children and away from pets.

Store injections in plastic containers between 41 and 77 degrees F (5 and 25 degrees C). Store away from heat, moisture, and light. Protect from freezing. Brief exposure up to 104 degrees F (40 degrees C) will not affect the product.

Do not store in the bathroom. Keep fluconazole solution, as well as syringes and needles, out of the reach of children and away from pets.

General information:

  • If you have any questions about fluconazole solution, please talk with your doctor, pharmacist, or other health care provider.
  • Fluconazole solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take fluconazole solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about fluconazole solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to fluconazole solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using fluconazole solution.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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