Generic Name: epoprostenol (E-poe-PROS-te-nol)
Brand Name: Examples include Flolan and Veletri
Flolan is used for:
Treating high blood pressure in the blood vessels of the lungs (pulmonary arterial hypertension [PAH]) to improve exercise capacity.
Flolan is a prostaglandin. It works by relaxing the blood vessels, which increases blood flow to the lungs.
Do NOT use Flolan if:
- you are allergic to any ingredient in Flolan or to a similar medicine (eg, treprostinil)
- you have congestive heart failure caused by severe left-sided heart problems
- you have previously taken Flolan and developed fluid in the lungs (pulmonary edema)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Flolan:
Some medical conditions may interact with Flolan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
Some MEDICINES MAY INTERACT with Flolan. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Diuretics (eg, furosemide, hydrochlorothiazide), medicines for high blood pressure, or other vasodilators (eg, minoxidil) because the risk of low blood pressure may be increased
- Anticoagulants (eg, warfarin) or antiplatelet medicines (eg, aspirin, clopidogrel) because the risk of bleeding may be increased by Flolan
- Digoxin because the risk of its side effects may be increased by Flolan
This may not be a complete list of all interactions that may occur. Ask your health care provider if Flolan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Flolan:
Use Flolan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Flolan is given as an intravenous (IV) infusion. If you will be using Flolan at home, a health care provider will teach you how to use it. Be sure you understand how to use Flolan. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Flolan must be mixed with a certain type of solution. Do not use any other type of solution to mix Flolan. After Flolan has been mixed, do not combine or mix it with any other solutions or medicines. Contact your doctor or pharmacist if you are unsure which type of solution to mix Flolan with.
- Do not use Flolan if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Flolan, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Flolan.
Important safety information:
- Tell your doctor or dentist that you take Flolan before you receive any medical or dental care, emergency care, or surgery.
- Flolan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Flolan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not suddenly stop using Flolan. You may experience a recurrence of PAH symptoms (eg, shortness of breath, dizziness, weakness). Discuss any questions or concerns with your doctor.
- If your symptoms do not get better or if they get worse, check with your doctor.
- Flolan may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Flolan while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Flolan, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Flolan:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Abnormal skin sensations (eg, burning, numbness, tingling); agitation; anxiety; back pain; diarrhea; dizziness; flu-like symptoms (eg, mild fever, mild chills, muscle aches); flushing; headache; loss of appetite; mild pain or redness at the injection site; muscle, bone, joint, or jaw pain; nausea; nervousness; stomach pain; sweating; tiredness; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or dark urine; chest pain; dark, tarry, or bloody stools; fainting; fast, slow, or irregular heartbeat; light-headedness; new or worsening shortness of breath; pale skin; severe or persistent dizziness; skin ulcers; swelling of the hands, arms, ankles, or feet; swelling of the stomach; symptoms of infection (eg, fever, chills, persistent sore throat, cough); tremor; unusual or increased bruising or bleeding; unusual tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Flolan:
Flolan is usually handled and stored by a health care provider. If you are using Flolan at home, store Flolan as directed by your pharmacist or health care provider. Keep Flolan out of the reach of children and away from pets.
- If you have any questions about Flolan, please talk with your doctor, pharmacist, or other health care provider.
- Flolan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Flolan or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Flolan. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Flolan. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Flolan.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Flolan (epoprostenol)
- Other brands: Veletri