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Extendryl syrup

Generic Name: chlorpheniramine/phenylephrine/methscopolamine (klor-fen-EER-a-meen/fen-ill-EF-rin/meth-skoe-POL-a-meen)
Brand Name: Examples include Dallergy and Extendryl

Extendryl syrup is used for:

Relieving congestion, sneezing, runny nose, and itchy, watery eyes due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Extendryl syrup is an antihistamine, decongestant, and anticholinergic combination. It works by blocking histamine, a substance in the body that causes sneezing, runny nose, and watery eyes. It also relieves nasal congestion by shrinking the nasal mucous membranes, which promotes nasal drainage, and dries the chest by decreasing lung secretions.

Do NOT use Extendryl syrup if:

  • you are allergic to any ingredient in Extendryl syrup
  • you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) in the last 14 days
  • you have narrow-angle glaucoma; a blockage of the bladder, stomach, or intestines; peptic ulcer disease; severe bowel problems (eg, ulcerative colitis); inflammation of the esophagus from reflux disease; difficulty swallowing; myasthenia gravis (muscle weakness); or uncontrolled bleeding
  • you have severe heart disease, severe high blood pressure, severe heart blood vessel problems, a rapid heartbeat, or you are unable to urinate
  • you are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

Video: Asthma

How to prevent and treat an asthma attack.

Before using Extendryl syrup:

Some medical conditions may interact with Extendryl syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of diabetes, an enlarged prostate, bladder or kidney problems, high blood pressure, asthma, lung problems (eg, emphysema), nerve problems, heart problems (eg, ischemic heart disease, irregular heartbeat), blood vessel problems, blood clots, stroke, a hiatal hernia, an adrenal gland tumor, increased pressure in the eye, glaucoma, or risk factors for glaucoma, breathing problems during sleep, seizures, trouble urinating, or an overactive thyroid
  • if you have diarrhea

Some MEDICINES MAY INTERACT with Extendryl syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Sodium oxybate (GHB) because the risk of severe drowsiness or coma may be increased
  • Furazolidone or MAOIs (eg, phenelzine) because severe high blood pressure, fast or irregular heartbeat, or seizures may occur
  • Alpha-blockers (eg, prazosin), anesthetics (eg, chloroform, lidocaine), anticholinergics (eg, atropine, benztropine, dicyclomine), beta-blockers (eg, propranolol), carbonic anhydrase inhibitors (eg, acetazolamide), diuretics (eg, furosemide, hydrochlorothiazide), ergotamine, tricyclic antidepressants (eg, amitriptyline), or urinary alkalinizers (eg, sodium bicarbonate) because they may increase the risk of Extendryl syrup's side effects
  • Bromocriptine, catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), certain stimulants (eg, doxapram, pseudoephedrine), cocaine, digoxin, droxidopa, or potassium chloride because the risk of their side effects may be increased by Extendryl syrup
  • Clonidine, guanethidine, guanfacine, mecamylamine, methyldopa, and reserpine because their effectiveness may be decreased by Extendryl syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if Extendryl syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Extendryl syrup:

Use Extendryl syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Extendryl syrup by mouth with or without food.
  • Do not take Extendryl syrup at the same time as antacids, certain medicines for diarrhea (eg, kaolin, pectin, attapulgite, bismuth), or ketoconazole. Take these medicines 2 or 3 hours before or after you take Extendryl syrup.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of Extendryl syrup and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Extendryl syrup.

Important safety information:

  • Extendryl syrup may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Extendryl syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Extendryl syrup; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • If your symptoms do not get better within 7 days or if you develop a high fever or persistent headache, check with your doctor.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Extendryl syrup may cause dry mouth. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.
  • Extendryl syrup may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • Extendryl syrup may reduce sweating. Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Do not take diet or appetite control medicines while you are taking Extendryl syrup without checking with your doctor.
  • Extendryl syrup has phenylephrine in it. Before you start any new medicine, check the label to see if it has phenylephrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take Extendryl syrup.
  • Tell your doctor or dentist that you take Extendryl syrup before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Extendryl syrup may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Extendryl syrup may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Extendryl syrup.
  • Use Extendryl syrup with caution in the ELDERLY; they may be more sensitive to its effects.
  • Extendryl syrup should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Extendryl syrup can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Extendryl syrup while you are pregnant. It is not known if Extendryl syrup is found in breast milk. Do not breast-feed while taking Extendryl syrup.

Possible side effects of Extendryl syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability or irritability (especially in children); flushing; headache; nausea; nervousness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; clumsiness; difficulty swallowing; fast or irregular heartbeat; hallucinations; mental or mood changes; seizures; tremor; trouble sleeping; trouble urinating; unusual bleeding or bruising; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; hallucinations; hot or cool skin; irregular heartbeat; irritability, anxiety, or panic; large pupils; numbness or tingling in the arms or legs; seizures; slowed or shallow breathing; vomiting.

Proper storage of Extendryl syrup:

Store Extendryl syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Extendryl syrup out of the reach of children and away from pets.

General information:

  • If you have any questions about Extendryl syrup, please talk with your doctor, pharmacist, or other health care provider.
  • Extendryl syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Extendryl syrup or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Extendryl syrup. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Extendryl syrup. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Extendryl syrup.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Watch this video series to learn about managing severe allergies (anaphylaxis).

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