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Epinephrine solution

Pronunciation

Generic Name: epinephrine (EP-i-NEF-rin)
Brand Name: Adrenalin

Epinephrine solution is used for:

Treating severe allergic reactions (eg, difficulty breathing; rash; hives; itching; tightness in the chest; severe dizziness; swelling of the mouth, lips, or tongue) caused by insect stings or bites, foods, drugs, or other causes. It is also used in the eye to dilate (widen) the pupil during eye surgery. It may also be used for other conditions as determined by your doctor.

Epinephrine solution is a sympathomimetic. It works on blood vessels to improve blood pressure and on the smooth muscle of the lungs to help breathing. It also works by decreasing rash, hives, and swelling. It works in the eye to widen the pupil during eye surgery.

Do NOT use epinephrine solution if:

  • you are allergic to any ingredient in epinephrine solution, unless your doctor tells you otherwise

Contact your doctor or health care provider right away if any of these apply to you.

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Before using epinephrine solution:

Some medical conditions may interact with epinephrine solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances (eg, sulfites)
  • if you have glaucoma, heart disease, chest pain, high blood pressure, blood vessel problems, diabetes, Parkinson disease, thyroid problems, adrenal gland problems (eg, pheochromocytoma), mood or mental problems (eg, depression), asthma, or an irregular heartbeat

Some MEDICINES MAY INTERACT with epinephrine solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Alpha-blockers (eg, prazosin), beta-blockers (eg, propranolol), droxidopa, ergot alkaloids (eg, ergotamine), or phenothiazines (eg, chlorpromazine) because the risk of high or low blood pressure and fast or slow heartbeat may be increased
  • Bromocriptine, furazolidone, linezolid, or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects, such as headache, high temperature, and high blood pressure, may be increased
  • Antihistamines (eg, diphenhydramine), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), digoxin, diuretics (eg, furosemide, hydrochlorothiazide), levothyroxine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), or medicines for irregular heartbeat (eg, quinidine) because they may increase the risk of epinephrine solution's side effects
  • Guanethidine because its effectiveness may be decreased by epinephrine solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if epinephrine solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use epinephrine solution:

Use epinephrine solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • For treating allergic reactions: Epinephrine solution may be given as an injection at your doctor's office, hospital, or clinic. If you will be using epinephrine solution at home, a health care provider will teach you how to use it. Be sure you understand how to use epinephrine solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • For eye surgery: Epinephrine solution is given as an injection into the eye at your doctor's office, hospital, or clinic.
  • Do not use epinephrine solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of epinephrine solution, contact your doctor right away.

Ask your health care provider any questions you may have about how to use epinephrine solution.

Important safety information:

  • Do not inject epinephrine solution into the buttocks. It may not provide effective treatment of an allergic reaction and could cause gangrene.
  • Never inject epinephrine solution into hands, fingers, feet, or toes. Doing so may cause a loss of blood flow and result in tissue damage to these areas. If you accidentally inject epinephrine solution into any of these areas, seek immediate emergency medical attention.
  • After eye surgery with epinephrine solution, your eyes may be more sensitive to light. Wearing sunglasses may help. Talk with your doctor.
  • Diabetes patients - Epinephrine solution may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur or persist, tell your doctor right away.
  • Patients with Parkinson disease may notice a temporary worsening of symptoms (eg, uncontrolled muscle movements). If these symptoms persist, contact your doctor.
  • Use epinephrine solution with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using epinephrine solution while you are pregnant. It is not known if epinephrine solution is found in breast milk. If you are or will be breast-feeding while you use epinephrine solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of epinephrine solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; dizziness; headache; nausea; nervousness; paleness; restlessness; shakiness; sweating; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast or irregular heartbeat; severe or persistent headache or dizziness; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of epinephrine solution:

Store epinephrine solution at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep epinephrine solution out of the reach of children and away from pets.

General information:

  • If you have any questions about epinephrine solution, please talk with your doctor, pharmacist, or other health care provider.
  • Epinephrine solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take epinephrine solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about epinephrine solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to epinephrine solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using epinephrine solution.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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