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Epinephrine/ lidocaine iontophoretic patch

Generic Name: epinephrine/lidocaine (EP-i-NEF-rin/LYE-doe-cane)
Brand Name: LidoSite Patch

Epinephrine/ lidocaine iontophoretic patch is used for:

Numbing the skin before you have certain medical procedures (eg, injections, minor skin surgery) in the treated area.

Epinephrine/lidocaine iontophoretic patch is a local anesthetic. It works by stopping nerves from transmitting painful impulses to the brain.

Do NOT use epinephrine/ lidocaine iontophoretic patch if:

  • you are allergic to any ingredient in epinephrine/lidocaine iontophoretic patch, other similar medicines (eg, amide-type medicines), or sulfites
  • you have an electrically-sensitive device (eg, pacemaker), or you are taking droxidopa

Contact your doctor or health care provider right away if any of these apply to you.

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Before using epinephrine/ lidocaine iontophoretic patch:

Some medical conditions may interact with epinephrine/lidocaine iontophoretic patch. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any anesthetic medicine (eg, benzocaine)
  • if you have broken, damaged, or inflamed skin at the application site
  • if you have heart problems, irregular heartbeat, liver problems, kidney problems, blood vessel problems, high blood pressure, poor circulation, or very poor health

Some MEDICINES MAY INTERACT with epinephrine/lidocaine iontophoretic patch. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Phenothiazines (eg, chlorpromazine) because the risk of low blood pressure and fast heartbeat may be increased
  • Beta-blockers (eg, propranolol), cimetidine, catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), mexiletine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), or tricyclic antidepressants (eg, imipramine) because they may increase the risk of epinephrine/lidocaine iontophoretic patch's side effects.
  • Antiarrhythmics (eg, amiodarone, tocainide), bromocriptine, or other local anesthetics (eg, benzocaine) because the risk of their side effects may be increased by epinephrine/lidocaine iontophoretic patch
  • Furazolidone or guanethidine because they may decrease epinephrine/lidocaine iontophoretic patch's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if epinephrine/lidocaine iontophoretic patch may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use epinephrine/ lidocaine iontophoretic patch:

Use epinephrine/lidocaine iontophoretic patch as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Epinephrine/lidocaine iontophoretic patch is usually applied at your doctor's office, hospital, or clinic. If you will be using epinephrine/lidocaine iontophoretic patch at home, a health care provider will teach you how to use it. Be sure you understand how to use epinephrine/lidocaine iontophoretic patch. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Epinephrine/lidocaine iontophoretic patch is only to be used on intact, clean, dry skin, Do not apply epinephrine/lidocaine iontophoretic patch to broken, damaged, inflamed, or hairy skin.
  • If you miss a dose of epinephrine/lidocaine iontophoretic patch, contact your doctor right away.

Ask your health care provider any questions you may have about how to use epinephrine/lidocaine iontophoretic patch.

Important safety information:

  • Epinephrine/lidocaine iontophoretic patch is for external use only. Avoid contact with your eyes, nose, and mouth. If you get epinephrine/lidocaine iontophoretic patch your eyes, rinse immediately with cool water.
  • Epinephrine/lidocaine iontophoretic patch may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
  • Epinephrine/lidocaine iontophoretic patch may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use epinephrine/lidocaine iontophoretic patch with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Epinephrine/lidocaine iontophoretic patch should stay in complete contact with your skin. Avoid body movements that may cause the patch to release from your skin. Tell your doctor at once if your patch comes off.
  • Tell your doctor or dentist that you take epinephrine/lidocaine iontophoretic patch before you receive any medical or dental care, emergency care, or surgery.
  • Epinephrine/lidocaine iontophoretic patch will cause a numbing effect at the application site. Do not scratch, rub, or expose the area to extreme hot or cold temperature until the numbness is gone.
  • Use epinephrine/lidocaine iontophoretic patch with caution in the ELDERLY; they may be more sensitive to its effects.
  • Epinephrine/lidocaine iontophoretic patch should be used with extreme caution in CHILDREN younger than 5 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using epinephrine/lidocaine iontophoretic patch while you are pregnant. Epinephrine/lidocaine iontophoretic patch is found in breast milk. If you are or will be breast-feeding while you use epinephrine/lidocaine iontophoretic patch, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of epinephrine/ lidocaine iontophoretic patch:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Minor redness, burning, irritation, or numbness at the application site; lightheadedness; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dizziness; fainting; fast, slow, or irregular heartbeat; loss of consciousness; mental or mood changes; nervousness; paleness; redness or warmth of skin; ringing in the ears or hearing changes; seizures; sensation of heat or cold; shortness of breath; swelling or blistering of skin; tremors or twitching; vision changes or double vision; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of epinephrine/lidocaine iontophoretic patch:

Store epinephrine/lidocaine iontophoretic patch at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat and light. Keep the child-resistant envelope sealed at all times when not in use. Keep epinephrine/lidocaine iontophoretic patch out of the reach of children and away from pets.

General information:

  • If you have any questions about epinephrine/lidocaine iontophoretic patch, please talk with your doctor, pharmacist, or other health care provider.
  • Epinephrine/lidocaine iontophoretic patch is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about epinephrine/lidocaine iontophoretic patch. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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